3-bromo-5-methylbenzoic acid
- Product Name
- 3-bromo-5-methylbenzoic acid
- CAS No.
- 58530-13-5
- Chemical Name
- 3-bromo-5-methylbenzoic acid
- Synonyms
- 5-broMo-3-Methylbenzoic acid;3-bromo-5-methylbenzoic acid;Benzoic acid, 3-bromo-5-methyl-
- CBNumber
- CB61558780
- Molecular Formula
- C8H7BrO2
- Formula Weight
- 215.04
- MOL File
- 58530-13-5.mol
3-bromo-5-methylbenzoic acid Property
- Melting point:
- 178-179.5℃
- Boiling point:
- 320.3±30.0 °C(Predicted)
- Density
- 1.599±0.06 g/cm3 (20 ºC 760 Torr)
- storage temp.
- Sealed in dry,Room Temperature
- form
- solid
- pka
- 3.88±0.10(Predicted)
- color
- Pale yellow
- InChIKey
- NWOMVQDBDBUANF-UHFFFAOYSA-N
Safety
- HS Code
- 2916310090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- S17907
- Product name
- 3-BROMO-5-METHYLBENZOIC ACID
- Purity
- Aldrich
- Packaging
- 100mg
- Price
- $179
- Updated
- 2024/03/01
- Product number
- B687935
- Product name
- 3-BROMO-5-METHYLBENZOIC ACID
- Packaging
- 5g
- Price
- $415
- Updated
- 2021/12/16
- Product number
- FB71947
- Product name
- 3-Bromo-5-methylbenzoic acid
- Packaging
- 25g
- Price
- $550
- Updated
- 2021/12/16
- Product number
- 2721-9-18
- Product name
- 3-Bromo-5-methylbenzoic acid
- Packaging
- 25g
- Price
- $864
- Updated
- 2021/12/16
- Product number
- HCH0068600
- Product name
- 3-BROMO-5-METHYL-BENZOIC ACID
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $958.65
- Updated
- 2021/12/16
3-bromo-5-methylbenzoic acid Chemical Properties,Usage,Production
Chemical Properties
Off-white powder
Uses
3-Bromo-5-methylbenzoic Acid is an intermediate used to synthesize quinoline amide derivatives as novel VEGFR-2 inhibitors
Synthesis
1-bromo-3,5-dimethylbenzene (15 g, 81 mmol, 1.0 eq) in a mixture of pyridine (133 mL) and H2O (83 mL) was heated to 80°C. KMnO4 (25.6 g, 162 mmol, 2.0 eq) was added in portions over 45 min. After the addition was completed, heating was continued at 80°C for 1.5 h. The hot solution was then filtered, and the filtrate was acidified by addition of concentrated hydrochloric acid. The aqueous solution was extracted with EtOAc and the combined organic extracts washed with water and brine, dried (Na2SO4), filtered and evaporated in vacuo. The residue was purified by column chromatography (CH2Cl2 : MeOH, 80:1 to 40:1) to give 3-bromo-5-methylbenzoic acid. White solid, yield (5.2 g, 29 %). LC-MS: m/z 212.9, 215 [M+H]+. 1H NMR (400 MHz, MeOD) δ 7.91 (s, 1H), 7.79 (s, 1H), 7.57 (s, 1H), 2.38 (s, 3H).
3-bromo-5-methylbenzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
3-bromo-5-methylbenzoic acid Suppliers
View Lastest Price from 3-bromo-5-methylbenzoic acid manufacturers
- Product
- 3-Bromo-5-methylbenzoic acid 58530-13-5
- Price
- US $100.00-30.00/kg
- Min. Order
- 1kg
- Purity
- 99.93%
- Supply Ability
- 1000kg per week
- Release date
- 2024-04-22
- Product
- 3-bromo-5-methylbenzoic acid 58530-13-5
- Price
- US $50.00/kg
- Min. Order
- 1kg
- Purity
- 99.9%
- Supply Ability
- 10000MT
- Release date
- 2023-08-02
- Product
- 3-bromo-5-methylbenzoic acid 58530-13-5
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2023-07-03