5-Amino-2-methylbenzoic acid

Product Name: 5-Amino-2-methylbenzoic acid
CAS No.: 2840-04-2
Chemical Name: 5-Amino-2-methylbenzoic acid
Synonyms: TIMTEC-BB SBB007566;RARECHEM AL BO 1282;5-Amino-2-methylbenz;5-Amino-o-toluic acid;2-Methyl-5-Aminobenzoic;2-METHYL-5-AMINOBENZOIC ACID;5-AMINO-2-METHYL-BENZOIC ACID;METHYL 5-AMION-2-METHYLBENZOATE;Benzoic acid, 5-amino-2-methyl-;5-Amino-2-methylbenzoic Acid >
CBNumber: CB5732692
Molecular Formula: C8H9NO2
Formula Weight: 151.16
MOL File: 2840-04-2.mol

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5-Amino-2-methylbenzoic acid Property

Melting point:: 194-199 °C
Boiling point:: 348.8±30.0 °C(Predicted)
Density: 1.254±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO (Slightly), Ethyl acetate (Very Slightly, Heated)
pka: 2.95±0.25(Predicted)
form: Solid
color: Light Brown
InChI: InChI=1S/C8H9NO2/c1-5-2-3-6(9)4-7(5)8(10)11/h2-4H,9H2,1H3,(H,10,11)
InChIKey: FSXVZWAWYKMFMX-UHFFFAOYSA-N
SMILES: C(O)(=O)C1=CC(N)=CC=C1C
CAS DataBase Reference: 2840-04-2(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 22-36/37/38
Safety Statements: 26
HS Code: 29224999

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: A2373
Product name: 5-Amino-2-methylbenzoic Acid
Purity: >98.0%(T)
Packaging: 5g
Price: $104
Updated: 2025/07/31

TCI Chemical

Product number: A2373
Product name: 5-Amino-2-methylbenzoic Acid
Purity: >98.0%(T)
Packaging: 25g
Price: $313
Updated: 2025/07/31

TRC

Product number: A614380
Product name: 5-Amino-2-methylbenzoic Acid
Packaging: 25g
Price: $95
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA36679
Product name: 5-Amino-2-methylbenzoic acid
Packaging: 100g
Price: $300
Updated: 2021/12/16

Matrix Scientific

Product number: 072579
Product name: 5-Amino-2-methylbenzoic acid
Purity: 95+%
Packaging: 25g
Price: $166
Updated: 2021/12/16

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5-Amino-2-methylbenzoic acid Chemical Properties,Usage,Production

Chemical Properties

Beige powder

Uses

5-Amino-2-methylbenzoic Acid is used as a reagent in synthesis of several organic compounds including that of dihydroxylphenyl amides which are Hsp90 inhibitors. Also used in synthesis of a series of 2,5-diaminopyrimidine inhibitors of bruton’s tyrosine kinase with potential for use in cancer drug development.

Synthesis

1975-52-6

2840-04-2

General procedure for the synthesis of 5-amino-2-methylbenzoic acid from 2-methyl-5-nitrobenzoic acid: 2-methyl-5-nitrobenzoic acid (30.0 g, 0.166 mol) and Pd/C catalyst (1.8 g) were suspended in anhydrous methanol (1600 mL). The reaction mixture was stirred at 40 °C for 3 to 4 h at a hydrogen pressure of 50 Psi. The progress of the reaction was monitored by thin layer chromatography (TLC, unfolding agent ratio of petroleum ether: ethyl acetate = 1:2) and after confirming that the reaction was complete, the catalyst was removed by filtration. The filtrate was concentrated under reduced pressure to afford 5-amino-2-methylbenzoic acid (24 g, 96% yield) as a white solid.1H NMR (400 MHz, CDCl3) data were as follows: δ 7.10 (s, 1H), 6.89-6.91 (d, J=8.0 Hz, 1H), 6.64-6.66 (dd, J=8.0 Hz, 1H), 2.31 (s, 3H).

References

[1] Journal of Medicinal Chemistry, 1996, vol. 39, # 17, p. 3343 - 3356
[2] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 23, p. 6273 - 6278
[3] Patent: WO2006/117669, 2006, A1. Location in patent: Page/Page column 41; 114
[4] Tetrahedron, 2018, vol. 74, # 47, p. 6795 - 6803
[5] Chemische Berichte, 1883, vol. 16, p. 1959

5-Amino-2-methylbenzoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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5-Amino-2-methylbenzoic acid Suppliers

Americas 1 China 164 Europe 4 Germany 1 India 7 Japan 1 Switzerland 1 The Netherlands 1 Ukraine 1 United Kingdom 7 United States 22 Global 210

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View Lastest Price from 5-Amino-2-methylbenzoic acid manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 5-Amino-2-methylbenzoic acid 2840-04-2
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 10000KGS
Release date: 2025-05-13

Changzhou waston chemical technology Co.,Ltd

Product: 5-Amino-2-methylbenzoic acid 2840-04-2
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: follow your request
Release date: 2023-06-01

CE Pharm Co.,Ltd

Product: 5-Amino-2-methylbenzoic acid 2840-04-2
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10tons
Release date: 2019-12-24

2840-04-2, 5-Amino-2-methylbenzoic acidRelated Search:

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2-METHYL-5-AMINOBENZOIC ACID

5-AMINO-2-METHYL-BENZOIC ACID

5-AMINO-2-METHYLBENZOIC ACID / 2-METHYL-5-AMINOBENZOIC ACID

RARECHEM AL BO 1282

TIMTEC-BB SBB007566

METHYL 5-AMION-2-METHYLBENZOATE

Benzoic acid, 5-amino-2-methyl- (9CI)

2-Methyl-5-Aminobenzoic

5-Amino-o-toluic acid

5-Amino-2-methylbenz

3-Carboxy-4-methylaniline, 4-Amino-2-carboxytoluene, 5-Amino-o-toluic acid

5-Amino-2-methylbenzoic Acid &gt

Benzoic acid, 5-amino-2-methyl-

2840-04-2

2840-4-2

2840/4/2

Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts

Carboxylic Acids

Phenyls & Phenyl-Het

Benzoic acid

Organic acids

Carboxylic Acids

Phenyls & Phenyl-Het

CARBOXYLICACID