5-Amino-2-methylbenzoic acid
- Product Name
- 5-Amino-2-methylbenzoic acid
- CAS No.
- 2840-04-2
- Chemical Name
- 5-Amino-2-methylbenzoic acid
- Synonyms
- TIMTEC-BB SBB007566;RARECHEM AL BO 1282;5-Amino-2-methylbenz;5-Amino-o-toluic acid;2-Methyl-5-Aminobenzoic;2-METHYL-5-AMINOBENZOIC ACID;5-AMINO-2-METHYL-BENZOIC ACID;METHYL 5-AMION-2-METHYLBENZOATE;Benzoic acid, 5-amino-2-methyl-;5-Amino-2-methylbenzoic Acid >
- CBNumber
- CB5732692
- Molecular Formula
- C8H9NO2
- Formula Weight
- 151.16
- MOL File
- 2840-04-2.mol
5-Amino-2-methylbenzoic acid Property
- Melting point:
- 194-199 °C
- Boiling point:
- 348.8±30.0 °C(Predicted)
- Density
- 1.254±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO (Slightly), Ethyl acetate (Very Slightly, Heated)
- pka
- 2.95±0.25(Predicted)
- form
- Solid
- color
- Light Brown
- InChI
- InChI=1S/C8H9NO2/c1-5-2-3-6(9)4-7(5)8(10)11/h2-4H,9H2,1H3,(H,10,11)
- InChIKey
- FSXVZWAWYKMFMX-UHFFFAOYSA-N
- SMILES
- C(O)(=O)C1=CC(N)=CC=C1C
- CAS DataBase Reference
- 2840-04-2(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-36/37/38
- Safety Statements
- 26
- HS Code
- 29224999
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- A2373
- Product name
- 5-Amino-2-methylbenzoic Acid
- Purity
- >98.0%(T)
- Packaging
- 5g
- Price
- $104
- Updated
- 2025/07/31
- Product number
- A2373
- Product name
- 5-Amino-2-methylbenzoic Acid
- Purity
- >98.0%(T)
- Packaging
- 25g
- Price
- $313
- Updated
- 2025/07/31
- Product number
- A614380
- Product name
- 5-Amino-2-methylbenzoic Acid
- Packaging
- 25g
- Price
- $95
- Updated
- 2021/12/16
- Product number
- A767
- Product name
- 5-Amino-2-methylbenzoic Acid
- Packaging
- 1g
- Price
- $14
- Updated
- 2021/12/16
- Product number
- 4657-1-Y1
- Product name
- 5-Amino-2-methylbenzoic acid
- Packaging
- 250mg
- Price
- $35
- Updated
- 2021/12/16
5-Amino-2-methylbenzoic acid Chemical Properties,Usage,Production
Chemical Properties
Beige powder
Uses
5-Amino-2-methylbenzoic Acid is used as a reagent in synthesis of several organic compounds including that of dihydroxylphenyl amides which are Hsp90 inhibitors. Also used in synthesis of a series of 2,5-diaminopyrimidine inhibitors of bruton’s tyrosine kinase with potential for use in cancer drug development.
Synthesis
1975-52-6
2840-04-2
General procedure for the synthesis of 5-amino-2-methylbenzoic acid from 2-methyl-5-nitrobenzoic acid: 2-methyl-5-nitrobenzoic acid (30.0 g, 0.166 mol) and Pd/C catalyst (1.8 g) were suspended in anhydrous methanol (1600 mL). The reaction mixture was stirred at 40 °C for 3 to 4 h at a hydrogen pressure of 50 Psi. The progress of the reaction was monitored by thin layer chromatography (TLC, unfolding agent ratio of petroleum ether: ethyl acetate = 1:2) and after confirming that the reaction was complete, the catalyst was removed by filtration. The filtrate was concentrated under reduced pressure to afford 5-amino-2-methylbenzoic acid (24 g, 96% yield) as a white solid.1H NMR (400 MHz, CDCl3) data were as follows: δ 7.10 (s, 1H), 6.89-6.91 (d, J=8.0 Hz, 1H), 6.64-6.66 (dd, J=8.0 Hz, 1H), 2.31 (s, 3H).
References
[1] Journal of Medicinal Chemistry, 1996, vol. 39, # 17, p. 3343 - 3356
[2] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 23, p. 6273 - 6278
[3] Patent: WO2006/117669, 2006, A1. Location in patent: Page/Page column 41; 114
[4] Tetrahedron, 2018, vol. 74, # 47, p. 6795 - 6803
[5] Chemische Berichte, 1883, vol. 16, p. 1959
5-Amino-2-methylbenzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
5-Amino-2-methylbenzoic acid Suppliers
- Tel
- 800-4238616
- Fax
- +1-888-520-1075 / +1-503-283-1987
- sales@tciamerica.com
- Country
- Americas
- ProdList
- 23653
- Advantage
- 75
View Lastest Price from 5-Amino-2-methylbenzoic acid manufacturers
- Product
- 5-Amino-2-methylbenzoic acid 2840-04-2
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-05-13
- Product
- 5-Amino-2-methylbenzoic acid 2840-04-2
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- follow your request
- Release date
- 2023-06-01
- Product
- 5-Amino-2-methylbenzoic acid 2840-04-2
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10tons
- Release date
- 2019-12-24