Methyl 2-amino-3-nitrobenzoate
- Product Name
- Methyl 2-amino-3-nitrobenzoate
- CAS No.
- 57113-91-4
- Chemical Name
- Methyl 2-amino-3-nitrobenzoate
- Synonyms
- Methyl 3-nitroanthranilate;2-AMINO-3-NITROBENZOIC ACID METHYL ESTER;Azilsartan SM1-E;RARECHEM AH CK 0023;Amylocaine Impurity 1;Methyl3-Nitroanthranilate>METHYL 2-AMINO-3-NITROBENZOATE;2-Amino-3-nitro-benzoic acid meth;Methyl 2-amino-3-nitrobenzoate 95%;3-Nitro-anthranilic Acid Methyl Ester
- CBNumber
- CB6157641
- Molecular Formula
- C8H8N2O4
- Formula Weight
- 196.16
- MOL File
- 57113-91-4.mol
Methyl 2-amino-3-nitrobenzoate Property
- Melting point:
- 97-98°C
- Boiling point:
- 340.1±22.0 °C(Predicted)
- Density
- 1.386±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- DMSO, Ethyl Acetate
- pka
- -2.80±0.25(Predicted)
- form
- Solid
- color
- Yellow
- InChI
- InChI=1S/C8H8N2O4/c1-14-8(11)5-3-2-4-6(7(5)9)10(12)13/h2-4H,9H2,1H3
- InChIKey
- HDCLJQZLTMJECA-UHFFFAOYSA-N
- SMILES
- C(OC)(=O)C1=CC=CC([N+]([O-])=O)=C1N
- CAS DataBase Reference
- 57113-91-4(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-22
- Safety Statements
- 26-36/37/39
- Hazard Note
- Irritant
- HS Code
- 2916399090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- ANV00032
- Product name
- 2-Amino-3-nitrobenzoic acid methylester
- Purity
- Aldrich<SUP>CPR</SUP>
- Packaging
- 1 g
- Price
- $185
- Updated
- 2025/07/31
- Product number
- M2158
- Product name
- Methyl 3-Nitroanthranilate
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $245
- Updated
- 2025/07/31
- Product number
- M286920
- Product name
- Methyl2-Amino-3-nitrobenzoate
- Packaging
- 2.5g
- Price
- $875
- Updated
- 2021/12/16
- Product number
- OR8159
- Product name
- Methyl2-amino-3-nitrobenzoate
- Purity
- 95%
- Packaging
- 1g
- Price
- $15
- Updated
- 2021/12/16
- Product number
- 008931
- Product name
- 2-Amino-3-nitrobenzoicacidmethylester
- Purity
- 98%
- Packaging
- 250mg
- Price
- $15
- Updated
- 2021/12/16
Methyl 2-amino-3-nitrobenzoate Chemical Properties,Usage,Production
Chemical Properties
Yellow Solid
Uses
Methyl 2-amino-3-nitrobenzoate is used as an intermediate in the preparation of Candesartan.
Synthesis
67-56-1
606-18-8
57113-91-4
2-Amino-3-nitrobenzoic acid (1.00 g, 5.49 mmol) was dissolved in methanol (40 mL) followed by the addition of concentrated sulfuric acid (0.50 mL). The reaction mixture was heated to reflux for 48 hours. Upon completion of the reaction, the mixture was cooled to room temperature and the pH was adjusted with saturated aqueous sodium bicarbonate to about 9. The mixture was concentrated under reduced pressure to about 10 mL, water (20 mL) was added, and the mixture was extracted with ethyl acetate (10 mL x 3 times). The organic layers were combined and dried with anhydrous magnesium sulfate. The organic layers were concentrated under reduced pressure and the resulting crystals were dried to give methyl 2-amino-3-nitrobenzoate. The product was structurally confirmed by nuclear magnetic resonance hydrogen spectroscopy (1H-NMR). Yield: 661.4 mg (61%). 1H-NMR (270 MHz, CDCl3): δ 8.50 (br, s), 8.37 (1H, dd, J = 8.6, 1.4 Hz), 8.23 (1H, dd, J = 7.6, 1.4 Hz), 6.65 (1H, dd, J = 8.6, 7.6 Hz), 3.92 (3H, s ) ppm.
References
[1] Patent: EP1452528, 2004, A1. Location in patent: Page 21-22
[2] Patent: EP1502916, 2005, A1. Location in patent: Page 435
[3] Journal of Medicinal Chemistry, 2000, vol. 43, # 22, p. 4084 - 4097
[4] Journal of Organic Chemistry, 2013, vol. 78, # 17, p. 8217 - 8231
[5] Patent: WO2007/100295, 2007, A1. Location in patent: Page/Page column 253
Methyl 2-amino-3-nitrobenzoate Preparation Products And Raw materials
Raw materials
Preparation Products
Methyl 2-amino-3-nitrobenzoate Suppliers
- Tel
- --
- Fax
- --
- info@trc-canada.com
- Country
- Canada
- ProdList
- 6038
- Advantage
- 71
- Tel
- --
- Fax
- --
- info@trc-canada.com
- Country
- Canada
- ProdList
- 6668
- Advantage
- 58
- Tel
- --
- Fax
- --
- info@vihita.com
- Country
- Canada
- ProdList
- 73
- Advantage
- 38
View Lastest Price from Methyl 2-amino-3-nitrobenzoate manufacturers
- Product
- Methyl 2-amino-3-nitrobenzoate 57113-91-4
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- Customise
- Release date
- 2025-08-19
- Product
- Methyl 2-amino-3-nitrobenzoate 57113-91-4
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-17
- Product
- Methyl 2-amino-3-nitrobenzoate 57113-91-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1ton
- Release date
- 2018-08-06