ChemicalBook > CAS DataBase List > Methyl 2-amino-3-nitrobenzoate

Methyl 2-amino-3-nitrobenzoate

Product Name
Methyl 2-amino-3-nitrobenzoate
CAS No.
57113-91-4
Chemical Name
Methyl 2-amino-3-nitrobenzoate
Synonyms
Methyl 3-nitroanthranilate;2-AMINO-3-NITROBENZOIC ACID METHYL ESTER;Azilsartan SM1-E;RARECHEM AH CK 0023;Amylocaine Impurity 1;Methyl3-Nitroanthranilate>METHYL 2-AMINO-3-NITROBENZOATE;2-Amino-3-nitro-benzoic acid meth;Methyl 2-amino-3-nitrobenzoate 95%;3-Nitro-anthranilic Acid Methyl Ester
CBNumber
CB6157641
Molecular Formula
C8H8N2O4
Formula Weight
196.16
MOL File
57113-91-4.mol
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Methyl 2-amino-3-nitrobenzoate Property

Melting point:
97-98°C
Boiling point:
340.1±22.0 °C(Predicted)
Density 
1.386±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
DMSO, Ethyl Acetate
pka
-2.80±0.25(Predicted)
form 
Solid
color 
Yellow
InChI
InChI=1S/C8H8N2O4/c1-14-8(11)5-3-2-4-6(7(5)9)10(12)13/h2-4H,9H2,1H3
InChIKey
HDCLJQZLTMJECA-UHFFFAOYSA-N
SMILES
C(OC)(=O)C1=CC=CC([N+]([O-])=O)=C1N
CAS DataBase Reference
57113-91-4(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-22
Safety Statements 
26-36/37/39
Hazard Note 
Irritant
HS Code 
2916399090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
ANV00032
Product name
2-Amino-3-nitrobenzoic acid methylester
Purity
Aldrich<SUP>CPR</SUP>
Packaging
1 g
Price
$185
Updated
2025/07/31
TCI Chemical
Product number
M2158
Product name
Methyl 3-Nitroanthranilate
Purity
>98.0%(GC)
Packaging
1g
Price
$245
Updated
2025/07/31
TRC
Product number
M286920
Product name
Methyl2-Amino-3-nitrobenzoate
Packaging
2.5g
Price
$875
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0020249
Product name
2-AMINO-3-NITROBENZOIC ACID METHYL ESTER
Purity
95.00%
Packaging
1G
Price
$808.89
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0020249
Product name
2-AMINO-3-NITROBENZOIC ACID METHYL ESTER
Purity
95.00%
Packaging
2.5G
Price
$1147.43
Updated
2021/12/16
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Methyl 2-amino-3-nitrobenzoate Chemical Properties,Usage,Production

Chemical Properties

Yellow Solid

Uses

Methyl 2-amino-3-nitrobenzoate is used as an intermediate in the preparation of Candesartan.

Synthesis

67-56-1

606-18-8

57113-91-4

2-Amino-3-nitrobenzoic acid (1.00 g, 5.49 mmol) was dissolved in methanol (40 mL) followed by the addition of concentrated sulfuric acid (0.50 mL). The reaction mixture was heated to reflux for 48 hours. Upon completion of the reaction, the mixture was cooled to room temperature and the pH was adjusted with saturated aqueous sodium bicarbonate to about 9. The mixture was concentrated under reduced pressure to about 10 mL, water (20 mL) was added, and the mixture was extracted with ethyl acetate (10 mL x 3 times). The organic layers were combined and dried with anhydrous magnesium sulfate. The organic layers were concentrated under reduced pressure and the resulting crystals were dried to give methyl 2-amino-3-nitrobenzoate. The product was structurally confirmed by nuclear magnetic resonance hydrogen spectroscopy (1H-NMR). Yield: 661.4 mg (61%). 1H-NMR (270 MHz, CDCl3): δ 8.50 (br, s), 8.37 (1H, dd, J = 8.6, 1.4 Hz), 8.23 (1H, dd, J = 7.6, 1.4 Hz), 6.65 (1H, dd, J = 8.6, 7.6 Hz), 3.92 (3H, s ) ppm.

References

[1] Patent: EP1452528, 2004, A1. Location in patent: Page 21-22
[2] Patent: EP1502916, 2005, A1. Location in patent: Page 435
[3] Journal of Medicinal Chemistry, 2000, vol. 43, # 22, p. 4084 - 4097
[4] Journal of Organic Chemistry, 2013, vol. 78, # 17, p. 8217 - 8231
[5] Patent: WO2007/100295, 2007, A1. Location in patent: Page/Page column 253

Methyl 2-amino-3-nitrobenzoate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Methyl 2-amino-3-nitrobenzoate manufacturers

Hefei Lbao Physical & Chemical Science Co.,Ltd
Product
Methyl 2-amino-3-nitrobenzoate 57113-91-4
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
Customise
Release date
2025-08-19
Henan Aochuang Chemical Co.,Ltd.
Product
Methyl 2-amino-3-nitrobenzoate 57113-91-4
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-10-17
Career Henan Chemical Co
Product
Methyl 2-amino-3-nitrobenzoate 57113-91-4
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1ton
Release date
2018-08-06

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