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DEXBROMPHENIRAMINE

Product Name
DEXBROMPHENIRAMINE
CAS No.
132-21-8
Chemical Name
DEXBROMPHENIRAMINE
Synonyms
Disomer;D-Brompheniramine;DEXBROMPHENIRAMINE;d-Parabromdylamine;(S)-Brompheniramine;DEXBROMPHENIRAMINE BASE;DEXBROMPHENIRAMINE USP/EP/BP;(S)-γ-(4-Bromophenyl)-N,N-dimethyl-2-pyridinepropan-1-amine;[(3S)-3-(4-bromophenyl)-3-(2-pyridyl)propyl]-dimethyl-amine;2-Pyridinepropanamine, γ-(4-bromophenyl)-N,N-dimethyl-, (γS)-
CBNumber
CB6164683
Molecular Formula
C16H19BrN2
Formula Weight
319.24
MOL File
132-21-8.mol
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DEXBROMPHENIRAMINE Property

alpha 
D25 +42.7° (c = 1 in DMF)
pka
pKa 9.3 (Uncertain)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
API0002276
Product name
DEXBROMPHENIRAMINE
Purity
95.00%
Packaging
5MG
Price
$345.4
Updated
2021/12/16
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DEXBROMPHENIRAMINE Chemical Properties,Usage,Production

Originator

Disomer,White,US,1959

Uses

Antihistaminic.

Definition

ChEBI: The (pharmacologically active) (S)-(+)-enantiomer of brompheniramine. A histamine H1 receptor antagonist, it is used (commonly as its maleate salt) for the symptomatic relief of allergic conditions, including rhinitis nd conjunctivitis.

Manufacturing Process

The following is taken from US Patent 3,061,517. Sixteen grams of racemic 3- (2-pyridyl)-3-p-bromophenyl-N,N,-dimethylpropylamine and 9.7 grams of dphenylsuccinic acid are dissolved in 150 ml of absolute alcohol and kept at room temperature until crystallization is effected. The crystals are filtered,washed with absolute ethyl alcohol, and recrystallized from the same solvent using 5 ml there of per gram of solid. Three subsequent crystallizations from 80% alcohol give d-3-(2-pyridyl)-3-p-bromophenyl-N,N-dimethylpropylamined-phenylsuccinate; MP 152-154°C; [α]D25 91 (concentration, 1% in dimethylformamide).
The free base, d-3-(2-pyridyl)-3-p-bromophenyl-N,N-dimethylpropylamine, is obtained from this salt with diethyl ether and aqueous potassium carbonate; [α]D25 +42.7 (concentration, 1% in dimethylformamide). The free base is then reacted with maleic acid.

brand name

Disomer (Schering).

Therapeutic Function

Antihistaminic

DEXBROMPHENIRAMINE Preparation Products And Raw materials

Raw materials

Preparation Products

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DEXBROMPHENIRAMINE Suppliers

Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12335
Advantage
58
Shanghai Han-Xiang Chemical Co., Ltd.
Tel
15971444841
Fax
18327183813
Email
amber@biochempartner.com
Country
China
ProdList
3061
Advantage
58
Shaanxi Dideu Medichem Co. Ltd
Tel
+86-029-89586680 +86-18192503167
Fax
+86-29-88380327
Email
1026@dideu.com
Country
China
ProdList
7724
Advantage
58
Ningbo jinuo chemical co., LTD
Tel
0574-87314919 057487319282
Email
info@nbinno.com
Country
China
ProdList
7032
Advantage
58
Hubei Nordina Biotechnology Co., Ltd.
Tel
19371278702
Fax
18162687220
Email
nuodinashengwu@163.com
Country
China
ProdList
971
Advantage
58
Hubei huizepu Pharmaceutical Technology Co., Ltd
Tel
023-19371278 19371278702
Email
n13164103386@163.com
Country
China
ProdList
3277
Advantage
58

132-21-8, DEXBROMPHENIRAMINERelated Search:


  • (S)-Brompheniramine
  • (S)-γ-(4-Bromophenyl)-N,N-dimethyl-2-pyridinepropan-1-amine
  • Disomer
  • d-Parabromdylamine
  • (3S)-3-(4-bromophenyl)-N,N-dimethyl-3-pyridin-2-yl-propan-1-amine
  • (3S)-3-(4-bromophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine
  • [(3S)-3-(4-bromophenyl)-3-(2-pyridyl)propyl]-dimethyl-amine
  • DEXBROMPHENIRAMINE
  • DEXBROMPHENIRAMINE BASE
  • D-Brompheniramine
  • 2-Pyridinepropanamine, γ-(4-bromophenyl)-N,N-dimethyl-, (γS)-
  • DEXBROMPHENIRAMINE USP/EP/BP
  • 132-21-8
  • 131-21-8