DL-ETHIONINE Property

Melting point:

265-268 °C

Boiling point:

310℃

alpha 

[α]D20 0±0.5° (c=5, dil. HCl)

Density 

1.164

refractive index 

1.5500 (estimate)

Flash point:

142℃

storage temp. 

-20°C

solubility 

Methanol (Slightly, Heated), Water (Slightly)

pka

2.23±0.10(Predicted)

form 

Crystalline Powder or Flakes

color 

White to off-white

Water Solubility 

Soluble in water.

Merck 

14,3738

BRN 

1722529

CAS DataBase Reference

67-21-0(CAS DataBase Reference)

EPA Substance Registry System

S-Ethylhomocysteine (67-21-0)

Safety

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26

WGK Germany 

3

RTECS 

ES6825200

TSCA 

Yes

HS Code 

29309090

Toxicity

The Sethyl analog of methionine. It is a carcinogen and hepatotoxic agent once proposed as an antineoplastic agent. It inhibits the incorporation of methionine and glycine into proteins and substitutes for methionine in transmethylation reactions, the ethyl group appearing in the products in place of the methyl groups of methionine (e.g., ethylcholine is formed instead of choline). Ethionine is currently used only as an experimental compound in studies of hepatotoxicity and methionine metabolism and nutrition.

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

DL-ETHIONINE Chemical Properties,Usage,Production

Chemical Properties

Off-White Solid

Uses

antineoplastic; inhibitor DNA methylation

Uses

DL-Ethionine is used as a dietary supplement to accelerate cholangiocarcinogenesis in vivo. It is also used to induce oxidative stress in liver to study the levels and activities of anti-oxidative enzymes and compounds such as glutathione.

Definition

ChEBI: A non-proteinogenic alpha-amino acid that is methionine in which the S-methyl group is replaced by an S-ethyl group.

General Description

White crystalline flakes.

Air & Water Reactions

Slightly soluble in water.

Reactivity Profile

A synthetic thio-substituted amino acid.

Health Hazard

ACUTE/CHRONIC HAZARDS: When heated to decomposition DL-ETHIONINE emits toxic fumes of NOx and SOx.

Fire Hazard

Flash point data for DL-ETHIONINE are not available; however, DL-ETHIONINE is probably combustible.

Biochem/physiol Actions

DL-Ethionine is a racemic mixture of the anti-methylation agent L-Ethionine and its enantiomer D-Ethionine. DL-Ethionine is used as a dietary supplement to accelerate cholangiocarcinogenesis in vivo. DL-Ethionine is used to induce oxidative stress in liver to study the levels and activities of anti-oxidative enzymes and compounds such as glutathione.

Safety Profile

Mddly toxic by ingestion and intraperitoneal routes. Suspected carcinogen with experimental carcinogenic and tumorigenic data. An experimental teratogen. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of SOx and NOx.