Choline chloride
B vitamins Content Analysis Toxicity Limited use Chemical Properties Production method- Product Name
- Choline chloride
- CAS No.
- 67-48-1
- Chemical Name
- Choline chloride
- Synonyms
- Choline Chloride pure;CHOLINE CHLORID;CHOLINE CHLORIDE POWDER;Choline Chloride 60% Corn COB;Lipotril;BIOCOLINA;HEPACHOLINE;HOEtN1,1,1Cl;Cholinchlorid;Cholinii chloridum
- CBNumber
- CB6166667
- Molecular Formula
- C5H14ClNO
- Formula Weight
- 139.62
- MOL File
- 67-48-1.mol
Choline chloride Property
- Melting point:
- 302-305 °C (dec.) (lit.)
- Density
- 1.0238 (rough estimate)
- refractive index
- 1.5400 (estimate)
- FEMA
- 4500 | Choline chloride (Also Includes Choline)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- H2O: 1 M, clear, colorless
- form
- Adhering Crystals
- color
- White
- Odor
- sl. odor of trimethylamine
- PH
- 5.0-7.5 (25℃, 1M in H2O)
- Water Solubility
- soluble
- Sensitive
- Hygroscopic
- λmax
- λ: 260 nm Amax: 0.015
λ: 280 nm Amax: 0.010 - Merck
- 14,2206
- JECFA Number
- 2003
- BRN
- 3563126
- Stability:
- Stable. Incompatible with strong oxidizing agents, moisture. Store under a dry atmosphere.
- InChIKey
- SGMZJAMFUVOLNK-UHFFFAOYSA-M
- LogP
- -3.70
- CAS DataBase Reference
- 67-48-1(CAS DataBase Reference)
- NIST Chemistry Reference
- Choline chloride(67-48-1)
- EPA Substance Registry System
- Choline chloride (67-48-1)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36
- WGK Germany
- 1
- RTECS
- KH2975000
- F
- 3-9
- TSCA
- Yes
- HS Code
- 29212900
- Hazardous Substances Data
- 67-48-1(Hazardous Substances Data)
- Toxicity
- LD50 in rats (g/kg): 0.400 i.p.; 6.64 orally (Hartung, Cornish)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H303May be harmfulif swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- W450001
- Product name
- Choline chloride
- Purity
- FCC
- Packaging
- 1kg
- Price
- $112
- Updated
- 2024/03/01
- Product number
- W450001
- Product name
- Choline chloride
- Purity
- FCC
- Packaging
- 5kg
- Price
- $382
- Updated
- 2024/03/01
- Product number
- 5.00117
- Product name
- Choline chloride
- Purity
- EMPROVE? ESSENTIAL, DAB 10, FCC
- Packaging
- 5KG
- Price
- $777
- Updated
- 2024/03/01
- Product number
- 5.00117
- Product name
- Choline chloride
- Purity
- EMPROVE? ESSENTIAL, DAB 10, FCC
- Packaging
- 25KG
- Price
- $2199
- Updated
- 2024/03/01
- Product number
- 1133547
- Product name
- Choline chloride
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 200mg
- Price
- $447
- Updated
- 2024/03/01
Choline chloride Chemical Properties,Usage,Production
B vitamins
Choline is an indispensible fundamental component in humans and animal body, often referred to as B vitamins or vitamin B4, and is a necessary low-molecule organic compound for maintaining physiological function off animal body. It can be synthesized inside animal body but still often need to be supplied to dietary and is a kind of vitamin in maximal usage amount. Inside animal cells, it can be used to adjust the in vivo metabolism and conversion of fats, preventing the fat deposition and tissue degeneration of liver and kidney, and then promote the regeneration of amino acids, enhance utilization of amino acids as well as save some part of methionine.
Choline chloride is the most commonly used as well as most economical form of synthetic choline and is a water soluble vitamin, and is the component for constituting of acetylcholine, lecithin, and nerve phospholipids of biological tissue. Moreover, it can save methionine and is an important material required for livestock, poultry, and fish. Inside animal body, it can be used for adjusting in vivo metabolism and conversion of fats and can prevent the deposition in liver and related tissue degeneration. As a methyl donor, it can promote the re-formation of amino acids and improve the utilization of amino acids. It is mainly used as an additive for being mixing into the animal feed. During the exact usage process, in addition to prevent moisture deliquescence, you should also note that all kind of feeds usually take the addition of choline chloride as the last step. Because of its destruction effects on other vitamins, especially its rapid destruction on vitamin A, D, K in the presence of metal elements, multi-dimensional formulation should not include choline. Daily feed supplied with it should be used as soon as possible after the addition. Tests have showed that choline chloride is especially important for chicken poultry. Its synthetic amino acids and lecithin can be delivered to various locations inside chicken bodies, being able to prevent the fat deposition in the liver and kidney and accelerate the growth of chickens and increase egg production and hatchability.
The above information is edited by the Chemicalbook of Dai Xiongfeng.
Content Analysis
Accurately weigh sample of about 300 mg and put it into 250 ml Erlenmeyer flask; add 50 ml of glacial acetic acid and heated on a steam bath until complete dissolving. After cooling, add 10 ml of mercury acetic acid mercury test solution (TS-137) and 2 drops of gentian violet reagent; use the acetic acid solution of 0.1 mol/L perchloric acid for titration to green endpoint. At the same time carry out a blank test and make necessary calibration. Each Ml of 0.1mol/L perchloric acid is equivalent to 13.96 mg of choline chloride (C5 H14ClNO).
Toxicity
ADI does not make restrictive regulations (FAO/WHO, 2001).
GRAS (FDA, §182.5252, §182.8252, 2000);
LD50: 9000mg/kg (rat, oral).
Limited use
GMP limit (FDA§182.5252.2000);
Chemical Properties
It is white hygroscopic crystal and is odorless with fish stench. Its melting point of 240 ℃. Its 10% aqueous solution has a pH 5-6. However, it is unstable in alkaline solution. This product is easily soluble in water and ethanol but insoluble in ether, petroleum ether, benzene and carbon disulfide. It has a low toxicity with LD50 (rat, oral) being 3400 mg/kg.
Production method
(1) Continuous method for preparation of choline chloride solution: continuously send the trimethylamine hydrochloride and a certain amount of ethylene oxide separately through pump into the reactor; the reactants had a residence time at the reactor of 1-1.5h; the reaction was carried out under stirring and has its resulting product being continuously withdrawn so that the liquid level within the reactor remained stable. The withdrawn choline chloride extraction crude product entered into the stripper to obtain 60-80% choline chloride liquid product from the bottom.
(2) Trimethylamine hydrochloride was reacted with ethylene oxide, and then added with an organic acid for neutralization and further concentration to obtain the choline chloride (3) Chloro-ethanol was reacted with trimethylamine to generate choline chloride.
(3)Ethylene oxide method. It can be made from the reaction between ethylene oxide and trimethylamine.
Add the trimethylamine ethanol solution into the reactor, send through ethylene oxide at about 30 ℃ and stirring reaction of 4 hour and further obtain it through neutralization with hydrochloric acid (control PH at 6.5-7.0). The yield of the crude product can be as high as 98%. The crude product can further be subject to activated carbon decolorizing and vacuum concentration to obtain 70% aqueous solution. The aqueous solution was added with ground corn cobs, rice hull flour, wheat bran or diatomaceous earth and some other kinds of excipients and can give 50% of the powder.
(4) Chlorohydrin method. Use chlorohydrin to substitute ethylene oxide and hydrochloric acid; have it reacted with trimethylamine in the presence of a small amount of ethylene oxide or alkaline substance;
First add 100 parts of chlorohydrin into the reaction vessel, further add 130 parts of trimethylamine from the liquid surface, while supplying 1.7 parts of ethylene oxide to trigger the reaction. After the addition, stir at 32-38 ℃ for 4h with the yield being 84% (calculated from chlorohydrin). For example, if catalyzed with an alkaline substance (such as quaternary ammonium salts), the one-way conversion rate can reach over 97%.
Trimethylamine methanol solution and chlorohydrin is subject to heating reaction, concentration under reduced pressure, and re-crystallization to generate it.
Chemical Properties
White crystalline powder
Application
Choline chloride has been used:
as a component of choline acetyltransferase (ChAT) buffer and for choline uptake in cultured human neuroblastoma (SK-N-SH) cells
for choline standard curve generation for quantifying phospholipase D (PLD) activity
as a component of slice solution for the dissection of entorhinal-hippocampal brain slices
Uses
Choline chloride is an animal feed additive, classified as a water-soluble B-vitamin that increases animal growth. ChCl is added exogenously to feedstocks because it plays an essential role in fat transport and metabolism and protects cell membrane structure. It can be supplied to tissue culture media and animal feed additives and used as a clinical anti-fatty liver agent.
It can be used to treat fatty liver and cirrhosis. It can also be used as a feed additive, stimulating the ovaries to give birth to more eggs and farrow. It can also facilitate the weight-gaining process of livestock, fish, etc.
Choline chloride is effective in preventing and treating fat deposition and tissue degeneration in livestock and poultry organs. It can also promote the absorption and synthesis of amino acids. Moreover, it can enhance livestock's physical fitness and disease resistance, promote their growth and development, and improve poultry laying rate. The usage amount is 1-2 g/kg.
As a kind of feed additive, choline chloride has the following physiological effects: it can prevent the accumulation of fat in the liver and the kidney and tissue degeneration; it can promote the recombination of amino acids; it can improve the utilization efficiency of amino acids, especially the essential amino acid methionine in vivo. In Japan, 98% of the applied choline chloride is used as feed additives for chickens, pigs, cattle, fish, and other animals. Most of them have been processed into powder; the preparation process of 50% powder is that: first, add an appropriate excipient of specific particle size into the mixer prepared by previously adding an appropriate particle size of the excipient, and then add dropwise of aqueous solution of choline chloride, after mixing, drying to derive it. Some powder products are also blended with vitamins, minerals, and drugs. Choline chloride is a vitamin B-class drug that can be used for the treatment of hepatitis, liver function degradation, early cirrhosis, and pernicious anemia.
It is a precursor of acetylcholine and is a methyl donor in various metabolic processes and lipid metabolism.
Definition
ChEBI: Choline chloride is a quaternary ammonium salt with choline cation and chloride anion. It has a role as an animal growth promotant. It is a chloride salt and a quaternary ammonium salt. It contains a choline.
benefits
choleretic, lipotropic, hepatoprotectant
General Description
Choline chloride appears as white crystals. Practically neutral aqueous solution(NTP, 1992). It is a basic constituent of lecithin that is found in many plants and animal organs. It is important as a precursor of acetylcholine, as a methyl donor in various metabolic processes, and in lipid metabolism.
Air & Water Reactions
Deliquescent. Very soluble in water.
Reactivity Profile
An acidic organic salt. Materials in this group are generally soluble in water. The resulting solutions contain moderate concentrations of hydrogen ions and have pH's of less than 7.0. They react as acids to neutralize bases. These neutralizations generate heat, but less or far less than is generated by neutralization of inorganic acids, inorganic oxoacids, and carboxylic acid. They usually do not react as either oxidizing agents or reducing agents but such behavior is not impossible. Many of these compounds catalyze organic reactions.
Fire Hazard
Choline chloride is relatively nonflammable.
Biochem/physiol Actions
The enzymatic activities of butyrylcholinesterase (BChE) and paraoxonase 1 (PON1), two serum enzymes synthesized by the liver and related with inflammation, were decreased in a sepsis animal model injected with LPS. Choline chloride administered intravenously at 20 mg/kg body weight prevents the LPS-mediated decreases in the activities of these two enzymes .
Safety Profile
Poison by intraperitoneal and intravenous routes. Moderately toxic experimentally by ingestion and subcutaneous routes. Mutation data reported. A lipotropic agent which induces the reduction in fats contained in the liver. When heated to decomposition it emits toxic fumes of Cl-, SOx and NOx. See also CHOLINE.
Purification Methods
Extremely deliquescent. Check purity by AgNO3 titration or by titration of OH-base after passage through an anion-exchange column. Crystallise it from absolute EtOH, or EtOH/Et2O, dry it under vacuum and store it in a vacuum desiccator over P2O5 or Mg(ClO4)2. [Beilstein 4 IV 1443.]
Choline chloride Preparation Products And Raw materials
Raw materials
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View Lastest Price from Choline chloride manufacturers
- Product
- Choline chloride 67-48-1
- Price
- US $0.00-0.00/Kg/Drum
- Min. Order
- 1KG
- Purity
- 98.0%-100.5%;FCCV
- Supply Ability
- 10 TONS
- Release date
- 2021-06-23
- Product
- Choline Chloride 67-48-1
- Price
- US $120.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20ton
- Release date
- 2024-05-06
- Product
- Choline chloride 67-48-1
- Price
- US $9.00/KG
- Min. Order
- 25KG
- Purity
- 99%
- Supply Ability
- 2000T
- Release date
- 2021-06-04