ChemicalBook > CAS DataBase List > NARINGENIN CHALCONE

NARINGENIN CHALCONE

Product Name: NARINGENIN CHALCONE
CAS No.: 73692-50-9
Chemical Name: NARINGENIN CHALCONE
Synonyms: C06561;ISOSALIPURPOL;Naringein chalcone;NARINGENIN CHALCONE;(E)-Naringenin chalcone;2',4',6',4-TETRAHYDROXYCHALCONE;4,2',4',6'-Tetrahydroxychalcone;trans-2'4'6'4-tetrahydroxychalcone;Naringenin Chalcone(cis and trans mix);NARINGENIN CHALCONE(cis and trans Mix)(RG)
CBNumber: CB6171155
Molecular Formula: C15H12O5
Formula Weight: 272.25
MOL File: 73692-50-9.mol

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NARINGENIN CHALCONE Property

Melting point:: 173-174℃
Boiling point:: 538.7±50.0 °C(Predicted)
Density: 1.483±0.06 g/cm3(Predicted)
storage temp.: 4°C, protect from light
solubility: DMF:15.0(Max Conc. mg/mL);55.0(Max Conc. mM)
DMSO:10.0(Max Conc. mg/mL);36.0(Max Conc. mM)
Ethanol:1.0(Max Conc. mg/mL);3.6(Max Conc. mM)
form: A solid
pka: 6.82±0.40(Predicted)
color: Light yellow to orange
InChI: InChI=1S/C15H12O5/c16-10-4-1-9(2-5-10)3-6-12(18)15-13(19)7-11(17)8-14(15)20/h1-8,16-17,19-20H
InChIKey: YQHMWTPYORBCMF-UHFFFAOYSA-N
SMILES: C(C1=C(O)C=C(O)C=C1O)(=O)C=CC1=CC=C(O)C=C1
LogP: 2.826 (est)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Usbiological

Product number: 361831
Product name: Naringenin Chalcone
Packaging: 20mg
Price: $523
Updated: 2021/12/16

Arctom

Product number: CFN90606
Product name: Naringeninchalcone
Purity: ≥98%
Packaging: 20mg
Price: $168
Updated: 2021/12/16

Arctom

Product number: SY232491
Product name: Naringeninchalcone
Purity: ≥97%
Packaging: 10mg
Price: $171.82
Updated: 2021/12/16

AvaChem

Product number: 3383
Product name: Naringenin chalcone
Packaging: 20mg
Price: $275
Updated: 2021/12/16

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NARINGENIN CHALCONE Chemical Properties,Usage,Production

Chemical Properties

Soluble in organic solvents such as methanol, ethanol, and DMSO.

Uses

Naringenin chalcone is an orally active intermediate in flavonol biosynthesis. Naringenin chalcone induces Apoptosis. Naringenin chalcone inhibits the production of MCP-1 and NO. Naringenin chalcone exhibits anticancer activity against glioblastoma. Naringenin chalcone has anti-inflammatory and anti-allergic properties[1][2][3][4][5][6].

Definition

ChEBI: A member of the class of chalcones that is trans-chalcone substituted by hydroxy groups at positions 2' ,4, 4', and 6' respectively.

in vivo

Naringenin chalcone (0.8 mg/kg; p.o.; daily) reduces eosinophilic airway inflammation, airway hyperresponsiveness, suppressed Th2 cytokine production by splenic CD4⁺ T cells, and slightly reduced mucus overproduction in allergic asthmatic BALB/c mice^[2].
Naringenin chalcone (5-80 mg/kg; 24 days) reduced tumor volume and tumor weight in U87MG human glioblastoma xenograft Balb/c nude mice^[3].
Naringenin chalcone (p.o.) increases plasma adiponectin levels in diabetic mice^[4].
Naringenin chalcone (0.02%; i.v.) inhibits the anaphylactic response to IgE-mediated passive cutaneous anaphylaxis in CD-1 mice^[5].
Naringenin chalcone (20 mg/kg; p.o.; once) resultes in the detection of naringenin chalcone -2'-O-β-D-glucuronide in the plasma of male Sprague-Dawley rats^[6].

References

[1] Hirai S, et al. Inhibitory effect of naringenin chalcone on inflammatory changes in the interaction between adipocytes and macrophages. Life Sci. 2007 Sep 29;81(16):1272-9. DOI:10.1016/j.lfs.2007.09.001
[2] Iwamura C, et al. Naringenin chalcone suppresses allergic asthma by inhibiting the type-2 function of CD4 T cells. Allergol Int. 2010 Mar;59(1):67-73. DOI:10.2332/allergolint.09-OA-0118
[3] Zhang S, et al. Anti-cancer effect of naringenin chalcone is mediated via the induction of autophagy, apoptosis and activation of PI3K/Akt signalling pathway. Bangladesh Journal of Pharmacology, 2016, 11(3): 684-690.
[4] Horiba T, et al. Naringenin chalcone improves adipocyte functions by enhancing adiponectin production. Mol Cell Endocrinol. 2010 Jul 29;323(2):208-14. DOI:10.1016/j.mce.2010.03.020
[5] Escribano-Ferrer E, et al. In Vivo Anti-inflammatory and Antiallergic Activity of Pure Naringenin, Naringenin Chalcone, and Quercetin in Mice. J Nat Prod. 2019 Feb 22;82(2):177-182. DOI:10.1021/acs.jnatprod.8b00366
[6] Yoshimura M, et al. Identification and quantification of metabolites of orally administered naringenin chalcone in rats. J Agric Food Chem. 2009 Jul 22;57(14):6432-7. DOI:10.1021/jf901137x

NARINGENIN CHALCONE Preparation Products And Raw materials

Raw materials

Preparation Products

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NARINGENIN CHALCONE Suppliers

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View Lastest Price from NARINGENIN CHALCONE manufacturers

Career Henan Chemical Co

Product: NARINGENIN CHALCONE 73692-50-9
Price: US $6.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1kg, 10kg ,50kg
Release date: 2020-03-09

73692-50-9, NARINGENIN CHALCONERelated Search:

NARINGENIN Prunin Potassium persulfate isosalipurposide Naringin dihydrochalcone 3,3',4',5,6,7,8-heptamethoxyflavone Quercetagetin 3,5,6,7,3',4'-hexamethyl ether NARIRUTIN 5,7,3'-Trihydroxy-6,4',5'-triMethoxyflavone Naringin PONCIRIN cis-4-hydroxy-alpha,alpha,4-trimethylcyclohexanemethanol Naringenin trimethyl ether Cineole Arecoline hydrobromide Kaempferol Phloretin Naringenin

ISOSALIPURPOL

2',4',6',4-TETRAHYDROXYCHALCONE

NARINGENIN CHALCONE

C06561

NARINGENIN CHALCONE(cis and trans Mix)(RG)

Naringein chalcone

(2E)-3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-2-propen-1-one

4,2',4',6'-Tetrahydroxychalcone

trans-2'4'6'4-tetrahydroxychalcone

2-Propen-1-one,3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-

Naringenin Chalcone(cis and trans mix)

3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)prop-2-en-1-one

Tetrahydroxychalcone syn naringenin chalcone

(E)-Naringenin chalcone

Isosalipurpol|||Chalconaringenin|||trans-2'4'6'4-tetrahydroxychalcone

73692-50-9