4-chloro-6-iodo-7H-pyrrolo[2,3-d]pyrimidine
- Product Name
- 4-chloro-6-iodo-7H-pyrrolo[2,3-d]pyrimidine
- CAS No.
- 876343-10-1
- Chemical Name
- 4-chloro-6-iodo-7H-pyrrolo[2,3-d]pyrimidine
- Synonyms
- 4-chloro-6-iodo-7H-pyrrolo[2;4-Chloro-6-iodo-7H-pyrrol...;4-chloro-6-iodo-1H-pyrrolo[2,3-d]pyrimidine;4-chloro-6-iodo-7H-pyrrolo[2,3-d]pyrimidine;7H-Pyrrolo[2,3-d]pyrimidine, 4-chloro-6-iodo-;4-chloro-6-iodo-7H-pyrrolo[2,3-d]pyrimidine ISO 9001：2015 REACH;Product English Name: 4-Chloro-6-iodo-7H-pyrrolo[2,3-d]pyrimidine
- CBNumber
- CB61856132
- Molecular Formula
- C6H3ClIN3
- Formula Weight
- 279.47
- MOL File
- 876343-10-1.mol
4-chloro-6-iodo-7H-pyrrolo[2,3-d]pyrimidine Property
- Density
- 2.284±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 9.74±0.50(Predicted)
- Appearance
- Light yellow to yellow Solid
- InChI
- InChI=1S/C6H3ClIN3/c7-5-3-1-4(8)11-6(3)10-2-9-5/h1-2H,(H,9,10,11)
- InChIKey
- DXPVKZYVQANEDW-UHFFFAOYSA-N
- SMILES
- C1=NC(Cl)=C2C=C(I)NC2=N1
Safety
- HS Code
- 2933599590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C381673
- Product name
- 4-Chloro-6-iodo-7H-pyrrolo[2,3-d]pyrimidine
- Packaging
- 500mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- 3H32-M-06
- Product name
- 4-Chloro-6-iodo-7H-pyrrolo[2,3-d]pyrimidine
- Packaging
- 1g
- Price
- $225
- Updated
- 2021/12/16
- Product number
- FC138879
- Product name
- 4-Chloro-6-iodo-7H-pyrrolo[2,3-d]pyrimidine
- Packaging
- 1g
- Price
- $130
- Updated
- 2021/12/16
- Product number
- AK-27595
- Product name
- 4-Chloro-6-iodo-7H-pyrrolo[2,3-d]pyrimidine
- Purity
- 97%
- Packaging
- 1g
- Price
- $162
- Updated
- 2021/12/16
- Product number
- FC138879
- Product name
- 4-Chloro-6-iodo-7H-pyrrolo[2,3-d]pyrimidine
- Packaging
- 2g
- Price
- $200
- Updated
- 2021/12/16
4-chloro-6-iodo-7H-pyrrolo[2,3-d]pyrimidine Chemical Properties,Usage,Production
Synthesis
186519-89-1
876343-10-1
The general procedure for the synthesis of 4-chloro-6-iodo-7H-pyrrolo[2,3-d]pyrimidines from 4-chloro-7-(phenylsulfonyl)-7H-pyrrolo[2,3-d]pyrimidines was carried out as follows: according to the literature [20], 4-chloro-7-(phenylsulfonyl)-7H-pyrrolo[2,3-d]pyrimidines (1) (5.42 g, 18.5 mmol) were subjected to iodination reaction. Upon completion of the reaction, a 9:1 mixture of 2:3 (6.0 g) was obtained. The mixture was mixed with THF (125 mL) and a methanolic solution of 5 M NaOH (21 mL). After stirring for 2 hours at room temperature, saturated aqueous NH4Cl solution (125 mL) was added and the mixture was concentrated. The precipitate formed was collected by filtration and washed with water. Subsequently, the precipitate was ground with boiling acetonitrile (1 g/10 mL) to give 4-chloro-6-iodo-7H-pyrrolo[2,3-d]pyrimidine (3.96 g, 14.2 mmol, 77% yield) as a white solid with a melting point of 219 °C (decomposition) (220 °C reported in literature [20]).1H NMR (400 MHz, DMSO-d6) δ: 12.57 (s, 1H), 8.51 (s, 1H), 6.88 (s, 1H). The obtained 1H NMR data were in agreement with those reported in the literature [20].
References
[1] European Journal of Medicinal Chemistry, 2016, vol. 124, p. 583 - 607
[2] European Journal of Pharmaceutical Sciences, 2014, vol. 59, # 1, p. 69 - 82
[3] Patent: WO2015/959, 2015, A1
4-chloro-6-iodo-7H-pyrrolo[2,3-d]pyrimidine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-chloro-6-iodo-7H-pyrrolo[2,3-d]pyrimidine manufacturers
- Product
- 4-chloro-6-iodo-7H-pyrrolo[2,3-d]pyrimidine 876343-10-1
- Price
- US $0.00/KG
- Min. Order
- 0.001KG
- Purity
- 98%min
- Supply Ability
- 100kgs/month
- Release date
- 2022-05-10
- Product
- 4-chloro-6-iodo-7H-pyrrolo[2,3-d]pyrimidine 876343-10-1
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-12-06
- Product
- 4-chloro-6-iodo-7H-pyrrolo[2,3-d]pyrimidine 876343-10-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%-99.9%
- Supply Ability
- 100kg
- Release date
- 2020-01-10