Pazufloxacin mesilate

Product Name: Pazufloxacin mesilate
CAS No.: 163680-77-1
Chemical Name: Pazufloxacin mesilate
Synonyms: PASIL;T 3762;PAZUCROSS;PAZUFLOXACIN MESYLAS;Pazufloxacin mesilat;Mesylate pazufloxacin;PAZUFLOXACIN MESYLATE;PAZUFLOXACIN MESILATE;Pasofloxacin mesylate;PazufloxacinMesylate>
CBNumber: CB6188647
Molecular Formula: C17H19FN2O7S
Formula Weight: 414.4053632
MOL File: 163680-77-1.mol

More

Less

Pazufloxacin mesilate Property

Melting point:: >255°C (dec.)
alpha: D20 -64.2° (c = 1 in 1.0N NaOH)
storage temp.: -20°C Freezer
solubility: Aqueous Base (Slightly), DMSO (Slightly)
form: Solid
color: Off-White to Pale Yellow
CAS DataBase Reference: 163680-77-1(CAS DataBase Reference)

More

Less

Safety

Hazard Codes: Xi,C,F
Risk Statements: 36/37/38-34-11
Safety Statements: 26-45-36/37/39-16
RTECS: UU8815400
HS Code: 29349990

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

TCI Chemical

Product number: P1962
Product name: Pazufloxacin Mesylate
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $35
Updated: 2024/03/01

TCI Chemical

Product number: P1962
Product name: Pazufloxacin Mesylate
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $103
Updated: 2023/06/20

Cayman Chemical

Product number: 29249
Product name: Pazufloxacin (mesylate)
Packaging: 1g
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 29249
Product name: Pazufloxacin (mesylate)
Packaging: 25g
Price: $485
Updated: 2024/03/01

Cayman Chemical

Product number: 29249
Product name: Pazufloxacin (mesylate)
Packaging: 5g
Price: $116
Updated: 2024/03/01

More

Less

Pazufloxacin mesilate Chemical Properties,Usage,Production

Description

This fluoroquinolone was co-developed by Toyama and Mitsubishi Pharm and was launched for the intravenous therapy of respiratory, urinary, surgical, gynecological and systemic infections.

Description

Pazufloxacin is a broad-spectrum synthetic fluoroquinolone antibiotic. It is active against Gram-negative and Gram-positive bacteria, including clinical isolates of E. coli, K. pneumoniae, methicillin-susceptible and -resistant S. aureus, and methicillin-susceptible and -resistant S. epidermidis (MIC₉₀s = 0.05, 0.1, 0.39, 12.5, 0.39, and 6.25 μg/ml, respectively). It inhibits E. coli, P. aeruginosa, and S. aureus DNA gyrase (IC₅₀s = 0.88, 1.9, and 10.2 μg/ml, respectively) and S. aureus topoisomerase IV (IC₅₀ = 24.2 μg/ml) in cell-free assays. In vivo, pazufloxacin is active against systemic E. coli, K. pneumoniae, and methicillin-resistant S. aureus infections in mice (ED₅₀s = 0.15, 5.5, and 4.5 mg/kg, respectively).

Chemical Properties

Crystalline Solid

Uses

A fluorinated quinolone antibiotic. Antibacterial.

Synthesis

Pazufloxacin Mesilate is elegantly synthesized from commercially available 2,3,4,5-tetrafluorobenzoic acid (168) by an 11-step process with an overall yield 48% [68]. Starting material 168 was first treated with ethyl bromide and then with t-butyl cyanoacetate in the presence of potassium carbonate in DMSO in one flask to give acylated cyanoacetate 169. Intermediate 169 thus obtained without purification was refluxed in toluene with p-TSA to yield 4- cyanomethylbenzoate 170 in 90% yield from 168. Cyclopropanation at the benzylic position of 170 was performed by |á,|á-dialkylation with two equiv. of 1,2- dibromoethane under phase-transfer conditions to give cyanocyclopropyl compound 171. Cyano compound 171 was subjected to hydration with alkaline H2O2 to afford carboxamide 172 in 81% yield from 170. Subsequently, carboxamide 172 was treated with NaOCl for Hofmann rearrangement to give primary amine 173, which was protected as its N-acetyl derivative 174 for the next reaction. Treatment of 174 with imidazole in the presence of thionyl chloride and TEA generated an imidazolide intermediate, which was converted to |?-keto ester 175 by reacting with potassium ethyl malonate and MgCl2. Enamine 176 was obtained without purification by successive treatment of 175 with DMF-dimethylacetal and (S)-(+)-2-aminopropanol. Crude 176 was heated in DMSO in the presence of potassium carbonate to efficiently give tricycle product 177 in 80% yield from 174. Finally, the ethyl ester and acetamide in 177 were hydrolyzed under basic and acidic conditions, respectively, to give the free amine. Pazufloxacin mesilate (20) was obtained in 94% yield by treatment of its corresponding free amine with methanesulfonic acid in ethanol.

Pazufloxacin mesilate Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Pazufloxacin mesilate Suppliers

Canada 2 CHINA 272 Europe 2 Germany 2 India 15 Japan 1 Poland 1 Switzerland 2 United Kingdom 9 United States 31 Global 337

BOC Sciences

Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 14055
Advantage: 65

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4861
Advantage: 58

HBCChem, Inc.

Tel: +1-510-219-6317
Fax: +1-650-486-1361
Email: sales@hbcchem.com
Country: United States
ProdList: 10648
Advantage: 60

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4660
Advantage: 60

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32165
Advantage: 58

Aladdin Scientific

Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

LKT Laboratories, Inc.

Tel: --
Fax: --
Email: info@lktlabs.com
Country: United States
ProdList: 2164
Advantage: 64

3B Scientific Corporation

Tel: --
Fax: --
Email: sales@3bsc.com
Country: United States
ProdList: 6962
Advantage: 56

AlliChem, LLC

Tel: --
Fax: --
Email: sales@allichemllc.com
Country: United States
ProdList: 6516
Advantage: 60

Cayman Chemical Company

Tel: --
Fax: --
Email: cayman@caymanchem.com
Country: United States
ProdList: 6213
Advantage: 81

Selleck Chemicals LLC

Tel: --
Fax: --
Email: sales@selleckchem.com
Country: United States
ProdList: 1848
Advantage: 58

Pharmax NA Inc.

Tel: --
Fax: --
Email: info@pharmaxus.com
Country: United States
ProdList: 127
Advantage: 58

United States Biological

Tel: --
Fax: --
Email: chemicals@usbio.net
Country: United States
ProdList: 6214
Advantage: 80

MedChemExpress

Tel: --
Fax: --
Email: sales@medchemexpress.com
Country: United States
ProdList: 6398
Advantage: 58

TCI America

Tel: --
Fax: --
Email: sales@tciamerica.com
Country: United States
ProdList: 6909
Advantage: 75

Riedel-de Haen AG

Tel: --
Fax: --
Country: United States
ProdList: 6773
Advantage: 87

Medical Isotopes

Tel: --
Fax: --
Email: stohler@medicalisotopes.com
Country: United States
ProdList: 6181
Advantage: 68

Waterstone Technology, LLC

Tel: --
Fax: --
Email: sales@waterstonetech.com
Country: United States
ProdList: 6786
Advantage: 30

Altan Corporation

Tel: --
Fax: --
Email: OrderingService@AltanBiochemicals.com
Country: United States
ProdList: 1161
Advantage: 30

HONEST JOY HOLDINGS LIMITED

Tel: --
Fax: --
Email: sales@honestjoy.cn
Country: United States
ProdList: 6675
Advantage: 54

2A PharmaChem USA

Tel: --
Fax: --
Email: sales@2apharmachem.com
Country: United States
ProdList: 6137
Advantage: 39

APAC Pharmaceutical, LLC

Tel: --
Fax: --
Email: sales@apacpharma.com
Country: United States
ProdList: 6322
Advantage: 38

Fine Chem Trading LTD

Tel: --
Fax: --
Email: chemfinder@chemfinder.co.uk
Country: United States
ProdList: 1609
Advantage: 64

3B Scientific Corporation

Tel: --
Fax: --
Email: sales@3bsc.com
Country: United States
ProdList: 6718
Advantage: 47

Beta Pharma, Inc.

Tel: --
Fax: --
Email: sales@betapharma.com
Country: United States
ProdList: 6226
Advantage: 60

AK Scientific, Inc.

Tel: --
Fax: --
Email: sales@aksci.com
Country: United States
ProdList: 6347
Advantage: 65

EJY Tech, Inc.

Tel: --
Fax: --
Country: United States
ProdList: 448
Advantage: 30

BOSCHE SCIENTIFIC, LLC

Tel: --
Fax: --
Email: Sales@BoscheSci.com
Country: United States
ProdList: 6477
Advantage: 55

CGeneTech, Inc.

Tel: --
Fax: --
Email: qyu@cgenetech.com
Country: United States
ProdList: 959
Advantage: 30

Ennova MedChem Group Inc., formerly Arch Corporation

Tel: --
Fax: --
Email: sales@ennovamedchem.com
Country: United States
ProdList: 1218
Advantage: 42

ChemPacific Corporation

Tel: --
Fax: --
Email: sales@chempacific.com
Country: United States
ProdList: 6891
Advantage: 51

More

Less

View Lastest Price from Pazufloxacin mesilate manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Pazufloxacin mesilate 163680-77-1
Price: US $0.00-0.00/Kg/Drum
Min. Order: 1KG
Purity: 98%min
Supply Ability: 500KG
Release date: 2021-09-18

WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD

Product: Pazufloxacin mesilate 163680-77-1
Price: US $0.00/KG
Min. Order: 100g
Purity: 98%+
Supply Ability: 100kg
Release date: 2020-11-09

Hebei Mojin Biotechnology Co., Ltd

Product: Pazufloxacin mesilate 163680-77-1
Price: US $100.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 5000kg/week
Release date: 2021-06-11

163680-77-1, Pazufloxacin mesilateRelated Search:

5-Amino-2-methylpyridine 4-Aminopyridine Pefloxacin mesylate 3-Aminopyridine METSULFURON METHYL Bensulfuron methyl Kresoxim-methyl Methyl salicylate Thiophanate-methyl Methanesulfonic acid Phentolamine mesilate 4-Dimethylaminopyridine Methyl Fluorine PAZUFLOXACIN (PREPARATION FOR PAZUFLOXACIN MESILATE) Methyl bromide PAZUFLOXACIN MESYLATE methanesulfonate

(3S)-10-(1-AMinocyclopropyl)-9-fluror-2,3-dihydro-3-Methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid Methanesulfonate

Mesylate pazufloxacin

T 3762

PASIL

PAZUCROSS

PAZUFLOXACIN MESILATE

PAZUFLOXACIN MESYLATE

PAZUFLOXACIN METHANESULFONATE

pazufloxaxin methanesulfonate

(s)-yclopropyl)-9-fluoro-3-methyl-7-oxomonomethanesulfonate

2,3-de)-1,4-benzoxazine-6-carboxylicacid,2,3-dihydro-10-(1-aminocyclopropyl)-9-fluoro-3-methyl-7-oxo-7h-pyrido((s)-7h-pyrido(monomethanesulfonate

Pazufloxacin Monomethanesulfonate

Pazufloxacin mesilate VETRANAL

PAZUFLOXAXIN METHANESULFONATE 99%

(3S)-10-(1-Aminocyclopropyl)-9-fluror-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylicAcid,

(3S)-10-(1-Aminocyclopropyl)-9-fluror-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid, T-3761,

PAZUFLOXACIN MESYLAS

(3S)-10-(1-Aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid methanesulfonate

Pazufloxacin mesilat

7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 10-(1-aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-, (3S)-, monomethanesulfonate (9CI)

7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 10-(1-aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-, (S)-, monomethanesulfonate

Pazufloxacin mesylate, Pazufloxacin methanesulfonate

PazufloxacinMesylate&gt

7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 10-(1-aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-, (3S)-, methanesulfonate (1:1)

Pazufloxacin mesilate USP/EP/BP

Pazufloxacin mesylateQ: What is Pazufloxacin mesylate Q: What is the CAS Number of Pazufloxacin mesylate Q: What is the storage condition of Pazufloxacin mesylate Q: What are the applications of Pazufloxacin mesylate

(S)-10-(1-Aminocyclopropyl)-9-fluoro-3-methyl-7-oxo-3,7-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid methanesulfonic acid salt

Pazufloxacin Mesylate, ≥ 98.0%

Pasofloxacin mesylate

Pazucross|||Pazufloxacin mesilate|||T-3762|||Pazufloxacin methanesulfonate

163680-77-1

103680-77-1

C16H15FN2O4xCH3SO3H

C16H15FN2O4CH4SO3

C16H15FN2O4CH3SO3H

C17H19FN2O7S

C16H15FN2O4CH4O3S

C17H19FN2SO7

PAZUCROSS

Aromatics

Chiral Reagents

API

Intermediates & Fine Chemicals

Pharmaceuticals

Amines