Doxapram hydrochloride monohydrate
- Product Name
- Doxapram hydrochloride monohydrate
- CAS No.
- 7081-53-0
- Chemical Name
- Doxapram hydrochloride monohydrate
- Synonyms
- stimulexin;DOXAPRAM HCL;DoxapraM HCL API;Doxapram Hydrochoride;DOXAPRAM HYDROCHLORIDE;Doxapram hydrochloride CRS;DoxapraM Hydrochloride, USP;doxapramhydrochloridehydrate;Dopram hydrochloride hydrate;Doxapram hydrochloride monohyd
- CBNumber
- CB6189200
- Molecular Formula
- C24H30N2O2.ClH.H2O
- Formula Weight
- 432.99
- MOL File
- 7081-53-0.mol
Doxapram hydrochloride monohydrate Property
- Melting point:
- 217-219°
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Soluble in water, in alcohol and in methylene chloride.
- form
- Solid
- color
- White to off-white
- InChIKey
- ZOMBFZRWMLIDPX-UHFFFAOYSA-N
Safety
- RIDADR
- UN 2811 6.1 / PGIII
- HS Code
- 2934990002
- Toxicity
- LD50 orally in rats: 261 mg/kg (Goldenthal)
N-Bromosuccinimide Price
- Product number
- D2963000
- Product name
- Doxapram hydrochloride
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- d2963000
- Price
- $150
- Updated
- 2024/03/01
- Product number
- 1225000
- Product name
- Doxapram hydrochloride
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 200mg
- Price
- $436
- Updated
- 2024/03/01
- Product number
- BP135
- Product name
- Doxapram hydrochloride
- Purity
- British Pharmacopoeia (BP) Assay Standard
- Packaging
- 100MG
- Price
- $262
- Updated
- 2023/06/20
- Product number
- 23794
- Product name
- Doxapram (hydrochloride hydrate)
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 23794
- Product name
- Doxapram (hydrochloride hydrate)
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $57
- Updated
- 2024/03/01
Doxapram hydrochloride monohydrate Chemical Properties,Usage,Production
Description
Doxapram is a central respiratory stimulant. It increases respiration and phrenic nerve activity in anesthetized cats at a dose of 1.0 mg/kg. Doxapram acts through carotid chemoreceptors, lacking activity in anesthetized cats following carotid denervation. Formulations containing doxapram have been used to increase respiration in patients with chronic pulmonary disease, respiratory depression induced by drug overdose, and to stimulate deep breathing post-anesthesia.
Chemical Properties
White or almost white, crystalline powder.
Originator
Dopram,Robins,US,1965
Uses
antibacterial
Definition
ChEBI: The monohydrate form of doxapram hydrochloride. A central and respiratory stimulant with a brief duration of action, it is used as a temporary treatment of acute respiratory failure, particularly when superimposed on chronic obstructive pulmonary disease, nd of postoperative respiratory depression. It has also been used for treatment of postoperative shivering.
Manufacturing Process
(A) Preparation of α-(1-ethyl-3-pyrrolidyl)-α,α-diphenylacetonitrile: A
suspension of the sodium salt of diphenylacetonitrile was formed by the
dropwise addition at 50°C of 193 grams (1.0 mol) of diphenylacetonitrile to a
stirred suspension of 43 grams (1.1 mols) of sodium amide in 1 liter of dry
toluene. After addition was complete, the mixture was refluxed for 4 hours
and then, to the refluxing mixture, 1.0 mol of 1-ethyl-3-chloropyrrolidine was
added at a rapid dropwise rate with continuous stirring. After addition was
complete, stirring and refluxing were continued for 3 hours. The mixture was
then cooled and extracted with one normal hydrochloric acid. The aqueous
layer together with an oil layer were separated, made basic with dilute sodium
hydroxide, and extracted with ether. The ethereal solution was dried over
sodium sulfate and concentrated and the residue was distilled in vacuo. The
material crystallized from a 4:1 ethanol-water mixture.
(B) Preparation of 4-(β-chloroethyl)-3,3-diphenyl-1-ethyl-2-pyrrolidinone: A
solution of α,α-diphenyl-α-(1-ethyl-3-pyrrolidyl)-acetonitrile in 70% sulfuric
acid was heated at 130-140°C for 48 hours, poured onto ice, made basic with
sodium hydroxide, and extracted with chloroform. The chloroform solution was
acidified with hydrogen chloride gas, dried over sodium sulfate and
concentrated. The residue was refluxed in 500 ml of thionyl chloride for 3
hours; the resulting solution was concentrated in vacuo; and the residue wascrystallized from isopropyl ether.
(C) Preparation of doxapram hydrochloride [3,3-diphenyl-1-ethyl-4-(2-
morpholino-ethyl)-2-pyrrolidinone hydrochloride monohydrate]: A solution of
25 grams (0.076 mol) of 4-(2-chloroethyl)-3,3-diphenyl-1-ethyl-2-
pyrrolidinone and 13.3 grams (0.153 mol) of morpholine in 500 ml of absolute
ethanol was heated at 95°-120°C for 21 hours in a closed system and
concentrated in vacuo. The residue was dissolved in 300 ml of two normal
hydrochloric acid and extracted with 150 ml of ethyl acetate. A solid
crystallized (13 g) during the extraction and was removed by filtration. MP
217°-219°C. The acid extracts were made basic with sodium hydroxide and
extracted with ether, and the ether solution was concentrated in vacuo and
the residue was suspended in six normal hydrochloric acid. Additional
crystalline product formed and was recrystallized from two normal
hydrochloric acid. Yield, 10 grams; MP 217°-219°C. Total yield, 23 grams
(70%).
brand name
Dopram (Baxter Healthcare).
Therapeutic Function
Respiratory stimulant
General Description
Doxapram, 1-ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-2-pyrrolidinone hydrochloride hydrate (Dopram), has an obscuremolecular mechanism of action. Overall, it stimulatesrespiration by action on peripheral carotid chemoreceptors.It has use as a respiratory stimulant postanesthetically, afterCNS depressant drug overdose, in chronic obstructive pulmonarydiseases, and in the apneas. Dopram is administeredexclusively by intravenous injection. Because of the benzylalcohol content of the injectable formulation, Dopram mustnever be given to neonates.
Clinical Use
Postoperative respiratory depression
Acute respiratory failure
Drug interactions
Potentially hazardous interactions with other drugs
Anaesthetics: increased risk of arrhythmias with
volatile liquid general anaesthetics - avoid for at least
10 minutes after volatile liquid general anaesthetics.
Metabolism
Doxapram is extensively metabolised in the liver, and the major route of excretion of metabolites and a small amount of unchanged drug is thought to be via bile to the faeces.
Doxapram hydrochloride monohydrate Preparation Products And Raw materials
Raw materials
Preparation Products
Doxapram hydrochloride monohydrate Suppliers
- Tel
- Fax
- 86-21-57758967
- sales@boylechem.com
- Country
- China
- ProdList
- 2922
- Advantage
- 55
- Tel
- 010-82848833 400-666-7788
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 821-50328103-801 18930552037
- Fax
- 86-21-50328109
- 3bsc@sina.com
- Country
- China
- ProdList
- 15839
- Advantage
- 69
- Tel
- 400-6009262 16621234537
- Fax
- 021-64823266
- chenyj@titansci.com
- Country
- China
- ProdList
- 14103
- Advantage
- 59
- Tel
- 021-58099652-8005 13585536065
- Fax
- 021-58099609
- bin.wu@shlschem.com
- Country
- China
- ProdList
- 9809
- Advantage
- 59
- Tel
- 15527768850
- 1791901229@qq.com
- Country
- China
- ProdList
- 8843
- Advantage
- 52
- Tel
- 0571-82693216
- Fax
- +86-571-82880190
- info@yuhaochemical.com
- Country
- China
- ProdList
- 9387
- Advantage
- 52
- Tel
- 021-021-021-67601398-809-809-809 15221380277
- Fax
- 021-57711696
- marketing_china@spectrumchemical.com
- Country
- China
- ProdList
- 9658
- Advantage
- 60
- Tel
- 0871-65217109 13211707573;
- Fax
- 0871-65215563
- y.liu@mail.biobiopha.com
- Country
- China
- ProdList
- 5653
- Advantage
- 65
- Tel
- 021-61551611 13296011611
- Fax
- ＋86 21-50676805
- contact@trustwe.com
- Country
- China
- ProdList
- 9895
- Advantage
- 58
View Lastest Price from Doxapram hydrochloride monohydrate manufacturers
- Product
- Doxapram hydrochloride monohydrate 7081-53-0
- Price
- US $50.00/kg
- Min. Order
- 1kg
- Purity
- 99.9%
- Supply Ability
- 10000tons
- Release date
- 2023-08-22
- Product
- Doxapram HCl 7081-53-0
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 1000kg
- Release date
- 2023-06-07
- Product
- Doxapram Hydrochloride Monohydrate 7081-53-0
- Price
- US $10.00/Kg/Bag
- Min. Order
- 1Kg/Bag
- Purity
- 99%
- Supply Ability
- 20 Tons
- Release date
- 2021-11-18