ChemicalBook > CAS DataBase List > 4-Hydroxy-2-methylpyridine

4-Hydroxy-2-methylpyridine

Product Name: 4-Hydroxy-2-methylpyridine
CAS No.: 18615-86-6
Chemical Name: 4-Hydroxy-2-methylpyridine
Synonyms: 2-METHYL-PYRIDIN-4-OL;4-Pyridinol, 2-methyl-;2-Methylpyridin-4-ol 98%;4-HYDROXY-2-METHYLPYRIDINE;2-Methyl-4-hydroxy-pyridin;2-Methyl-4-hydroxypyridine;4-Hydroxy-2-methylpyridine ,97%;4-Hydroxy-2-methylpyridine nitrate;4-Hydroxy-2-methylpyridine ISO 9001：2015 REACH
CBNumber: CB6189396
Molecular Formula: C6H7NO
Formula Weight: 109.13
MOL File: 18615-86-6.mol

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4-Hydroxy-2-methylpyridine Property

Melting point:: 174-176 °C(Solv: acetone (67-64-1))
Boiling point:: 350-360 °C
Density: 1.120±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
pka: 5.36±0.18(Predicted)
Appearance: White to light yellow Solid

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Safety

Risk Statements: 36/37/38
Safety Statements: 24/25-36/37/39
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: M312885
Product name: 2-Methyl-4-hydroxypyridine
Packaging: 10g
Price: $745
Updated: 2021/12/16

Oakwood

Product number: 076527
Product name: 4-Hydroxy-2-methylpyridine
Purity: 98%
Packaging: 250mg
Price: $21
Updated: 2021/12/16

Matrix Scientific

Product number: 072752
Product name: 4-Hydroxy-2-methylpyridine
Purity: 95+%
Packaging: 1g
Price: $42
Updated: 2021/12/16

ChemScene

Product number: CS-W018581
Product name: 2-Methylpyridin-4-ol
Purity: 99.97%
Packaging: 5g
Price: $51
Updated: 2021/12/16

AK Scientific

Product number: J99680
Product name: 4-Hydroxy-2-methylpyridine
Packaging: 5g
Price: $55
Updated: 2021/12/16

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4-Hydroxy-2-methylpyridine Chemical Properties,Usage,Production

Chemical Properties

Yellow solid

Uses

2-Methyl-4-hydroxypyridine is used in the synthesis of novel indolizine compounds as inhibitors of phosphodiesterase IV. Also used in the preparation of 2-substituted imidazole ring compoiunds for treatment againast human African trypanosomiasis.

Synthesis

18437-58-6

18615-86-6

General procedure for the synthesis of 4-hydroxy-2-methylpyridine from 2-methyl-4-aminopyridine: [0220] To an aqueous solution (75 mL) containing 2-methylpyridin-4-amine (10.2 g, 94 mmol) and nitric acid (56.5 mL, 1,273 mmol) was slowly added a solution of sodium nitrite solution (9.44 g, 137 mmol) in water (38 mL) over a period of 25 minutes at 0 °C while maintaining vigorous stirring. The reaction mixture was continued to be stirred at 0 °C for 30 min, followed by transfer to a refrigerator at -17 °C for overnight storage. Upon completion of the reaction, the mixture was filtered and the solid product was collected and dried under vacuum to afford 2-methylpyridin-4-ol (6.5 g, 59.6 mmol, 63.2% yield) as a beige solid. The product was confirmed by 1H NMR (400 MHz, DMSO-d6): δ 2.53-2.60 (m, 3H), 7.01-7.17 (m, 2H), 8.36-8.49 (m, 1H). Mass spectrometry analysis showed a measured value of 110.1 for [M + H]+.

References

[1] Patent: WO2011/146287, 2011, A1. Location in patent: Page/Page column 59
[2] Archiv der Pharmazie (Weinheim, Germany), 1958, vol. 291, p. 429,434
[3] Roczniki Chemii, 1957, vol. 31, p. 1147,1151
[4] Chem.Abstr., 1958, p. 10072
[5] Journal of Chemical Thermodynamics, 1982, vol. 14, # 1, p. 45 - 50

4-Hydroxy-2-methylpyridine Preparation Products And Raw materials

Raw materials

Ethanol Potassium carbonate Chloroform Sodium nitrite Ethyl acetate Hydrochloric acid 4-Nitro-2-picoline N-oxide Dichloromethane Acetic acid Sodium hydroxide Iron Sulfuric acid

Preparation Products

6-CHLORO-4-METHOXY-PYRIDINE-2-CARBOXYLIC ACID

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View Lastest Price from 4-Hydroxy-2-methylpyridine manufacturers

Dideu Industries Group Limited

Product: 4-Hydroxy-2-methylpyridine 18615-86-6
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-09-24

Career Henan Chemical Co

Product: 4-Hydroxy-2-methylpyridine 18615-86-6
Price: US $1.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 200KG
Release date: 2018-12-23

18615-86-6, 4-Hydroxy-2-methylpyridineRelated Search:

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2-Methyl-4-hydroxy-pyridin

4-HYDROXY-2-METHYLPYRIDINE

2-METHYL-PYRIDIN-4-OL

2-Methyl-4-hydroxypyridine

4-Hydroxy-2-methylpyridine ,97%

4-Hydroxy-2-methylpyridine nitrate

2-Methylpyridin-4-ol 98%

4-Pyridinol, 2-methyl-

4-Hydroxy-2-methylpyridine ISO 9001：2015 REACH

18615-86-6

Pyridines

Heterocyclic Series