METHYL 3-BROMOTHIOPHENE-2-CARBOXYLATE
- Product Name
- METHYL 3-BROMOTHIOPHENE-2-CARBOXYLATE
- CAS No.
- 26137-08-6
- Chemical Name
- METHYL 3-BROMOTHIOPHENE-2-CARBOXYLATE
- Synonyms
- JACS-26137-08-6;RARECHEM AL BF 0362;METHYL 3-BROMOTHIOPH;3-broMo-2-thiophenecarboxylate;METHYL 3-BROMOTHIOPHENE-2-CARBOXYLATE;Methyl 3-Bromothiophene-2-carboxylate >Methyl 3-bromothiophene-2-carboxylate ,97%;Methyl 3-Bromothiophene-2-carboxylate, >=98%;3-BroMo-thiophene-2-carboxylicacidMethylester;3-bromo-2-thiophenecarboxylic acid methyl ester
- CBNumber
- CB6193397
- Molecular Formula
- C6H5BrO2S
- Formula Weight
- 221.07
- MOL File
- 26137-08-6.mol
METHYL 3-BROMOTHIOPHENE-2-CARBOXYLATE Property
- Melting point:
- 50 °C
- Boiling point:
- 112/4mm
- Density
- 1.662±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Store in freezer, under -20°C
- form
- Solid
- color
- White
- Water Solubility
- Slightly soluble in water.
- InChI
- InChI=1S/C6H5BrO2S/c1-9-6(8)5-4(7)2-3-10-5/h2-3H,1H3
- InChIKey
- PEGSJNCGPSIJOX-UHFFFAOYSA-N
- SMILES
- C1(C(OC)=O)SC=CC=1Br
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- M2590
- Product name
- Methyl 3-Bromothiophene-2-carboxylate
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $69
- Updated
- 2025/07/31
- Product number
- M2590
- Product name
- Methyl 3-Bromothiophene-2-carboxylate
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $231
- Updated
- 2025/07/31
- Product number
- 070853
- Product name
- Methyl 3-bromothiophene-2-carboxylate
- Purity
- 98%
- Packaging
- 1g
- Price
- $34
- Updated
- 2021/12/16
- Product number
- JK208850
- Product name
- Methyl 3-Bromothiophene-2-carboxylate
- Purity
- 97%
- Packaging
- 1g
- Price
- $94
- Updated
- 2021/12/16
- Product number
- 070853
- Product name
- Methyl 3-bromothiophene-2-carboxylate
- Purity
- 98%
- Packaging
- 5g
- Price
- $104
- Updated
- 2021/12/16
METHYL 3-BROMOTHIOPHENE-2-CARBOXYLATE Chemical Properties,Usage,Production
Chemical Properties
Off-white solid
Uses
Methyl 3-bromothiophene-2-carboxylate is employed as a intermediate for pharmaceutical and chemical research.
Synthesis
22288-78-4
26137-08-6
The general procedure for the synthesis of methyl 3-bromothiophene-2-carboxylate from methyl 3-amino-2-thiophenecarboxylate was as follows: methyl 3-amino-2-thiophenecarboxylate (100 g, 0.6369 mol) was suspended in hydrobromic acid (220 mL) and stirred at room temperature for 15 min. Subsequently, the mixture was cooled to 0-5 °C and a solution of sodium nitrite (46.0 g, 0.666 mol) in water (100 mL) was slowly added dropwise below 5 °C. After the dropwise addition, stirring was continued for 1 hour. The above mixture was then added to a solution of copper(I) bromide (96.0 g, 0.6692 mol) in hydrobromic acid (260 mL) at room temperature. The reaction system was warmed to 60-65 °C and the reaction was stirred for 2 hours. Upon completion of the reaction, the reaction mixture was diluted with 1200 mL of water at a controlled temperature of 25-30 °C and extracted with two portions of 600 mL of ethyl acetate. The organic phases were combined, washed twice successively with 600 mL of water and dried over anhydrous sodium sulfate. Ethyl acetate was removed by distillation under reduced pressure (60 °C) to give a yellow solid product of 129.0 g in 91.6% yield, melting point 47-48 °C, and HPLC purity of 96%. The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3): δ 3.90 (s, 3H, OCH3), 7.09 (d, 1H), 7.46 (d, 1H); 13C NMR (400 MHz, CDCl3): δ 52.10, 116.96, 127.12, 130.61, 133.63, 161.0; mass spectrum (MS): m/z 222.8 [M+1].
References
[1] Patent: WO2016/92556, 2016, A1. Location in patent: Page/Page column 27; 28
[2] Tetrahedron Letters, 2012, vol. 53, # 52, p. 7135 - 7139
[3] Chemistry - A European Journal, 2018, vol. 24, # 55, p. 14622 - 14626
[4] Patent: CN105164112, 2017, B. Location in patent: Paragraph 0473-0476
[5] Heterocycles, 1985, vol. 23, # 6, p. 1431 - 1435
METHYL 3-BROMOTHIOPHENE-2-CARBOXYLATE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from METHYL 3-BROMOTHIOPHENE-2-CARBOXYLATE manufacturers
- Product
- METHYL 3-BROMOTHIOPHENE-2-CARBOXYLATE 26137-08-6
- Price
- US $0.01/KG
- Min. Order
- 1KG
- Purity
- 98%； 99%
- Supply Ability
- 1kg; 5kg; 10kg；25kg
- Release date
- 2020-01-07