3-Chlorothiophene-2-carboxylic acid
- Product Name
- 3-Chlorothiophene-2-carboxylic acid
- CAS No.
- 59337-89-2
- Chemical Name
- 3-Chlorothiophene-2-carboxylic acid
- Synonyms
- EA160;AKOS 93295;BUTTPARK 29\06-43;RARECHEM AL BE 1228;TIMTEC-BB SBB003936;3-Chlorothiophene-2-c;Rivaroxaban Impurity RC-28;3-CHLOROTHIOPHENE-2-CARBOXYLIC ACID;2-Thiophenecarboxylicacid, 3-chloro-;3-Chlorothiophene-2-carboxylicacid98%
- CBNumber
- CB5360611
- Molecular Formula
- C5H3ClO2S
- Formula Weight
- 162.59
- MOL File
- 59337-89-2.mol
3-Chlorothiophene-2-carboxylic acid Property
- Melting point:
- 186-190 °C (lit.)
- Boiling point:
- 291.7±20.0 °C(Predicted)
- Density
- 1.466 (estimate)
- storage temp.
- 2-8°C
- solubility
- DMSO (Sparingly), Methanol (Slightly)
- pka
- 3.09±0.10(Predicted)
- form
- solid
- color
- White to Off-White
- BRN
- 121052
- InChI
- InChI=1S/C5H3ClO2S/c6-3-1-2-9-4(3)5(7)8/h1-2H,(H,7,8)
- InChIKey
- BXEAAHIHFFIMIE-UHFFFAOYSA-N
- SMILES
- C1(C(O)=O)SC=CC=1Cl
- CAS DataBase Reference
- 59337-89-2(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36-24/25
- WGK Germany
- 3
- Hazard Note
- Irritant
- HS Code
- 29349990
- Storage Class
- 11 - Combustible Solids
- Hazard Classifications
- Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 586994
- Product name
- 3-Chlorothiophene-2-carboxylic acid
- Purity
- 97%
- Packaging
- 5g
- Price
- $153
- Updated
- 2025/07/31
- Product number
- C428155
- Product name
- 3-Chlorothiophene-2-carboxylic acid
- Packaging
- 500mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- C428155
- Product name
- 3-Chlorothiophene-2-carboxylic acid
- Packaging
- 1g
- Price
- $70
- Updated
- 2021/12/16
- Product number
- P000265776
- Product name
- 3-Chlorothiophene-2-carboxylic acid
- Purity
- 98%
- Packaging
- 10g
- Price
- $46
- Updated
- 2021/12/16
- Product number
- OR2721
- Product name
- 3-Chlorothiophene-2-carboxylic acid
- Purity
- 98%
- Packaging
- 1g
- Price
- $15
- Updated
- 2021/12/16
3-Chlorothiophene-2-carboxylic acid Chemical Properties,Usage,Production
Chemical Properties
white to light yellow crystal powder
Uses
3-Chlorothiophene-2-carboxylic acid may be used in the synthesis of 3-chloro-N-[(4-chlorophenyl)(methyl)carbamothioyl]thiophene-2-carboxamide.
Synthesis
88105-17-3
59337-89-2
GENERAL STEPS: Methyl 3-chlorothiophene-2-carboxylate (50 g, 0.28 mol) was dissolved in methanol (100 mL), aqueous sodium hydroxide solution (2M, 400 mL) was added slowly, and the reaction temperature was maintained at 0 °C. The reaction mixture was stirred at room temperature for 2 hours. After removal of methanol by distillation under reduced pressure, the aqueous phase was washed with ether and subsequently acidified with 2N hydrochloric acid to pH < 3. The precipitated white solid was collected by filtration and dried under vacuum to give 3-chlorothiophene-2-carboxylic acid (45 g, 98% yield). Mass spectrometry (MS) analysis showed a molecular ion peak (M+H+) of 163.
References
[1] Heterocycles, 1985, vol. 23, # 6, p. 1431 - 1435
[2] Patent: WO2012/139425, 2012, A1. Location in patent: Page/Page column 119
[3] Heterocycles, 2007, vol. 71, # 1, p. 87 - 104
[4] Patent: WO2013/28670, 2013, A1. Location in patent: Page/Page column 96
[5] Patent: US9181236, 2015, B2. Location in patent: Page/Page column 107
3-Chlorothiophene-2-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-Chlorothiophene-2-carboxylic acid manufacturers
- Product
- 3-Chlorothiophene-2-carboxylic acid 59337-89-2
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-29
- Product
- 3-Chlorothiophene-2-carboxylic acid 59337-89-2
- Price
- US $30.00-0.90/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-26
- Product
- 3-Chlorothiophene-2-carboxylicacid 59337-89-2
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- g/kg/T
- Release date
- 2019-12-18