4-CHLOROTHIOPHENE-2-CARBOXYLIC ACID
- Product Name
- 4-CHLOROTHIOPHENE-2-CARBOXYLIC ACID
- CAS No.
- 59614-95-8
- Chemical Name
- 4-CHLOROTHIOPHENE-2-CARBOXYLIC ACID
- Synonyms
- 2-Carboxy-4-chlorothiophene;4-chlorothiene-2-carboxylic acid;4-chloro-2-thionylcarboxylic acid;4-Chloro-2-thiophenecarboxylic acid;4-CHLOROTHIOPHENE-2-CARBOXYLIC ACID;2-Thiophenecarboxylic acid, 4-chloro-
- CBNumber
- CB1165438
- Molecular Formula
- C5H3ClO2S
- Formula Weight
- 162.59
- MOL File
- 59614-95-8.mol
4-CHLOROTHIOPHENE-2-CARBOXYLIC ACID Property
- Melting point:
- 131-132 °C(Solv: methanol (67-56-1))
- Boiling point:
- 298.0±20.0 °C(Predicted)
- Density
- 1.572±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 3.50±0.10(Predicted)
- color
- White to Off-White
Safety
- HS Code
- 2934999090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H312Harmful in contact with skin
H372Causes damage to organs through prolonged or repeated exposure
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P391Collect spillage. Hazardous to the aquatic environment
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- C428893
- Product name
- 4-Chlorothiophene-2-carboxylicAcid
- Packaging
- 50mg
- Price
- $85
- Updated
- 2021/12/16
- Product number
- Y9574
- Product name
- 4-Chlorothiophene-2-carboxylicacid
- Packaging
- 100mg
- Price
- $59
- Updated
- 2021/12/16
- Product number
- 6H21-5-X3
- Product name
- 4-Chlorothiophene-2-carboxylic acid
- Purity
- 95%
- Packaging
- 250mg
- Price
- $128
- Updated
- 2021/12/16
- Product number
- 6H21-5-X3
- Product name
- 4-Chlorothiophene-2-carboxylic acid
- Purity
- 95%
- Packaging
- 1g
- Price
- $480
- Updated
- 2021/12/16
- Product number
- HCH0295991
- Product name
- 4-CHLOROTHIOPHENE-2-CARBOXYLIC ACID
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $501.48
- Updated
- 2021/12/16
4-CHLOROTHIOPHENE-2-CARBOXYLIC ACID Chemical Properties,Usage,Production
Uses
4-Chlorothiophene-2-carboxylic Acid is a useful research chemical compound used as a chlroinating reagent in the preparation of 5-??(2-furoyl)??-??, 5-??(2-??thenoyl)??-??, 5-??(3-??furoyl)??- and 5-??(3-??thenoyl)??-??1,??2-??dihydro-??3H-??pyrrolo[1,??2-??a]??pyrrole-??1-??carboxylic acid derivatives.
Synthesis Reference(s)
Journal of Heterocyclic Chemistry, 13, p. 393, 1976 DOI: 10.1002/jhet.5570130241
Synthesis
35475-03-7
59614-95-8
General procedure for the synthesis of 4-chlorothiophene-2-carboxylic acid from methyl 5-chlorothiophene-2-carboxylate: to a solution of methyl 5-chlorothiophene-2-carboxylate (10.0 g, 61.5 mmol) in anhydrous methanol (55 mL) was slowly added concentrated sulfuric acid (5-7 mL). The reaction mixture was heated to 50 °C and maintained for 18 h for the reaction, followed by concentration under reduced pressure to remove the solvent. The concentrated residue was dissolved in dichloromethane and washed several times with saturated sodium bicarbonate solution to neutralize the acid. The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure to afford 10.85 g of the crude product of 4-chlorothiophene-2-carboxylic acid (~100% yield), which could be used in subsequent reactions without further purification.1H NMR (400 MHz, DMSO-d6): δ 7.66 (d, 1H, J = 4.0 Hz), 7.23 (d, 1H, J = 4.4 Hz), 7.23 (d, 1H, J = 4.4 Hz) 3.81 (s, 3H).
References
[1] Patent: US2018/201610, 2018, A1. Location in patent: Paragraph 0400; 0401
4-CHLOROTHIOPHENE-2-CARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-CHLOROTHIOPHENE-2-CARBOXYLIC ACID manufacturers
- Product
- 4-CHLOROTHIOPHENE-2-CARBOXYLIC ACID 59614-95-8
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-08
- Product
- 4-Chlorothiophene-2-carboxylic acid 59614-95-8
- Price
- US $1.00/Kg
- Min. Order
- 1Kg
- Purity
- 99.95
- Supply Ability
- 500KG
- Release date
- 2019-04-15