ChemicalBook > CAS DataBase List > 4-CHLOROTHIOPHENE-2-CARBOXYLIC ACID

4-CHLOROTHIOPHENE-2-CARBOXYLIC ACID

Product Name: 4-CHLOROTHIOPHENE-2-CARBOXYLIC ACID
CAS No.: 59614-95-8
Chemical Name: 4-CHLOROTHIOPHENE-2-CARBOXYLIC ACID
Synonyms: 2-Carboxy-4-chlorothiophene;4-chlorothiene-2-carboxylic acid;4-chloro-2-thionylcarboxylic acid;4-Chloro-2-thiophenecarboxylic acid;4-CHLOROTHIOPHENE-2-CARBOXYLIC ACID;2-Thiophenecarboxylic acid, 4-chloro-
CBNumber: CB1165438
Molecular Formula: C5H3ClO2S
Formula Weight: 162.59
MOL File: 59614-95-8.mol

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4-CHLOROTHIOPHENE-2-CARBOXYLIC ACID Property

Melting point:: 131-132 °C(Solv: methanol (67-56-1))
Boiling point:: 298.0±20.0 °C(Predicted)
Density: 1.572±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 3.50±0.10(Predicted)
color: White to Off-White

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Safety

HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H312Harmful in contact with skin

H372Causes damage to organs through prolonged or repeated exposure

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: C428893
Product name: 4-Chlorothiophene-2-carboxylicAcid
Packaging: 50mg
Price: $85
Updated: 2021/12/16

AK Scientific

Product number: Y9574
Product name: 4-Chlorothiophene-2-carboxylicacid
Packaging: 100mg
Price: $59
Updated: 2021/12/16

SynQuest Laboratories

Product number: 6H21-5-X3
Product name: 4-Chlorothiophene-2-carboxylic acid
Purity: 95%
Packaging: 250mg
Price: $128
Updated: 2021/12/16

SynQuest Laboratories

Product number: 6H21-5-X3
Product name: 4-Chlorothiophene-2-carboxylic acid
Purity: 95%
Packaging: 1g
Price: $480
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0295991
Product name: 4-CHLOROTHIOPHENE-2-CARBOXYLIC ACID
Purity: 95.00%
Packaging: 5MG
Price: $501.48
Updated: 2021/12/16

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4-CHLOROTHIOPHENE-2-CARBOXYLIC ACID Chemical Properties,Usage,Production

Uses

4-Chlorothiophene-2-carboxylic Acid is a useful research chemical compound used as a chlroinating reagent in the preparation of 5-??(2-furoyl)??-??, 5-??(2-??thenoyl)??-??, 5-??(3-??furoyl)??- and 5-??(3-??thenoyl)??-??1,??2-??dihydro-??3H-??pyrrolo[1,??2-??a]??pyrrole-??1-??carboxylic acid derivatives.

Synthesis Reference(s)

Journal of Heterocyclic Chemistry, 13, p. 393, 1976 DOI: 10.1002/jhet.5570130241

Synthesis

35475-03-7

59614-95-8

General procedure for the synthesis of 4-chlorothiophene-2-carboxylic acid from methyl 5-chlorothiophene-2-carboxylate: to a solution of methyl 5-chlorothiophene-2-carboxylate (10.0 g, 61.5 mmol) in anhydrous methanol (55 mL) was slowly added concentrated sulfuric acid (5-7 mL). The reaction mixture was heated to 50 °C and maintained for 18 h for the reaction, followed by concentration under reduced pressure to remove the solvent. The concentrated residue was dissolved in dichloromethane and washed several times with saturated sodium bicarbonate solution to neutralize the acid. The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure to afford 10.85 g of the crude product of 4-chlorothiophene-2-carboxylic acid (~100% yield), which could be used in subsequent reactions without further purification.1H NMR (400 MHz, DMSO-d6): δ 7.66 (d, 1H, J = 4.0 Hz), 7.23 (d, 1H, J = 4.4 Hz), 7.23 (d, 1H, J = 4.4 Hz) 3.81 (s, 3H).

References

[1] Patent: US2018/201610, 2018, A1. Location in patent: Paragraph 0400; 0401

4-CHLOROTHIOPHENE-2-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-CHLOROTHIOPHENE-2-CARBOXYLIC ACID manufacturers

Career Henan Chemical Co

Product: 4-CHLOROTHIOPHENE-2-CARBOXYLIC ACID 59614-95-8
Price: US $9.80/KG
Min. Order: 1g
Purity: ≥99%
Supply Ability: 100kg
Release date: 2020-01-08

Hebei Jimi Trading Co., Ltd.

Product: 4-Chlorothiophene-2-carboxylic acid 59614-95-8
Price: US $1.00/Kg
Min. Order: 1Kg
Purity: 99.95
Supply Ability: 500KG
Release date: 2019-04-15

59614-95-8, 4-CHLOROTHIOPHENE-2-CARBOXYLIC ACIDRelated Search:

4-CHLOROTHIOPHENE-2-CARBOXYLIC ACID

4-Chloro-2-thiophenecarboxylic acid

2-Carboxy-4-chlorothiophene

4-chloro-2-thionylcarboxylic acid

2-Thiophenecarboxylic acid, 4-chloro-

4-chlorothiene-2-carboxylic acid

59614-95-8