ChemicalBook > CAS DataBase List > 4-Amino-2-chloropyrimidine

4-Amino-2-chloropyrimidine

Product Name
4-Amino-2-chloropyrimidine
CAS No.
7461-50-9
Chemical Name
4-Amino-2-chloropyrimidine
Synonyms
2-CHLOROPYRIMIDIN-4-AMINE;2-CHLORO-4-PYRIMIDINAMINE;4-AMINO-2-CHLOROPYRIMIDINE;2-CHLORO-4-AMINOPYRIMIDINE;4-Pyrimidinamine, 2-chloro-;2-CHLOROPYRIMIDIN-4-YLAMINE;4-Amino-2-chloropyrimidin...;4-Amino-2-chloropyrimidine >4-Amino-2-chloropyrimidine ,97%;4-Pyrimidinamine, 2-chloro- (9CI)
CBNumber
CB6195861
Molecular Formula
C4H4ClN3
Formula Weight
129.55
MOL File
7461-50-9.mol
More
Less

4-Amino-2-chloropyrimidine Property

Melting point:
197-205 °C
Boiling point:
338.8±15.0 °C(Predicted)
Density 
1.437±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
form 
powder to crystal
pka
2.30±0.10(Predicted)
color 
White to Light yellow
InChI
InChI=1S/C4H4ClN3/c5-4-7-2-1-3(6)8-4/h1-2H,(H2,6,7,8)
InChIKey
LPBDZVNGCNTELM-UHFFFAOYSA-N
SMILES
C1(Cl)=NC=CC(N)=N1
CAS DataBase Reference
7461-50-9(CAS DataBase Reference)
More
Less

Safety

Hazard Codes 
Xn
Risk Statements 
36/37/38-36-22
Safety Statements 
26-36/37/39
WGK Germany 
3
HazardClass 
IRRITANT-HARMFUL
HS Code 
29335990
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
679062
Product name
4-Amino-2-chloropyrimidine
Purity
97%
Packaging
1g
Price
$59.1
Updated
2023/06/20
TCI Chemical
Product number
A2719
Product name
4-Amino-2-chloropyrimidine
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$39
Updated
2025/07/31
TCI Chemical
Product number
A2719
Product name
4-Amino-2-chloropyrimidine
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$150
Updated
2025/07/31
TRC
Product number
A617743
Product name
4-Amino-2-chloropyrimidine
Packaging
1g
Price
$45
Updated
2021/12/16
TRC
Product number
A617743
Product name
4-Amino-2-chloropyrimidine
Packaging
5g
Price
$130
Updated
2021/12/16
More
Less

4-Amino-2-chloropyrimidine Chemical Properties,Usage,Production

Chemical Properties

White to light brown solid

Uses

4-Amino-2-chloropyrimidine is a chloropyrimidine compound, which is widely used in the synthesis of various medicines and pesticides. It can be used to transform functional groups, such as amino groups, or to remove chlorine by hydrogenolysis; chlorine can also be used to couple various carbon-carbon bonds.

Synthesis

3934-20-1

7461-50-9

3993-78-0

2,4-Dichloropyrimidine (1.0 g, 6.7 mmol) was used as starting material and 28% w/v aqueous ammonium hydroxide solution (20 mL) was added. The reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure. The obtained residue was dried and subsequently purified by fast column chromatography (FCC) with the eluent being chloroform solution containing 2-10% ethanol, resulting in the isolation of 2-amino-4-chloropyrimidine and 2-chloro-4-aminopyrimidine. Product yields: 200 mg of 2-amino-4-chloropyrimidine in 23% yield and 600 mg of 2-chloro-4-aminopyrimidine in 69% yield.

References

[1] Patent: WO2010/20556, 2010, A1. Location in patent: Page/Page column 62
[2] Journal of the American Chemical Society, 2003, vol. 125, # 33, p. 9970 - 9982
[3] Tetrahedron, 2010, vol. 66, # 6, p. 1280 - 1288
[4] Patent: WO2006/114409, 2006, A1. Location in patent: Page/Page column 18
[5] Bioorganic and Medicinal Chemistry Letters, 1999, vol. 9, # 14, p. 1973 - 1978

4-Amino-2-chloropyrimidine Preparation Products And Raw materials

Raw materials

Silica gel Ammonium hydroxide Ethanol 2,4-Dichloropyrimidine Dichloromethane Methanol Ammonia

Preparation Products

2-ETHOXYPYRIMIDIN-4-YLAMINE
More
Less

4-Amino-2-chloropyrimidine Suppliers

Americas 1 China 267 Europe 2 Germany 2 India 4 Japan 2 Russia 1 Switzerland 1 The Netherlands 1 Ukraine 1 United Kingdom 11 United States 28 Global 321
Changzhou Ucheml Medicine Co., Ltd.
Tel
0519-86058959
Fax
0519-85286229
Email
2850886771@qq.com
Country
China
ProdList
222
Advantage
50
Changzhou hanergy Biotechnology Co., Ltd
Tel
13915872857
Email
hannengchemical@163.com
Country
China
ProdList
96
Advantage
58
SiChuang NanBu Honesty Technology Co., Ltd.
Tel
0838-5675166 15883665058
Fax
0838-5675535
Email
nbcxkj@126.com
Country
China
ProdList
918
Advantage
55
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006356688 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15838
Advantage
69
ITIC MEDCHEM(SUZHOU) CO.,LTD.
Tel
0512-68323967 18015559028
Fax
+86-512-69200360
Email
sales@iticmedchem.com
Country
China
ProdList
506
Advantage
61
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
ShangHai DEMO Chemical Co.,Ltd
Tel
400-021-7337 2355568890
Fax
0086-21-50182339
Email
sales@demochem.com
Country
China
ProdList
2572
Advantage
57
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44801
Advantage
61
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Country
China
ProdList
18207
Advantage
66
Beijing Ouhe Technology Co., Ltd
Tel
010-010-82967028 13522913783
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12000
Advantage
60
Shanghai Scientia Pharmaceutical Technology Co., Ltd.
Tel
21-21-54301573 13917723525
Fax
(86)21-51861981
Email
sales@scientiapharm.com
Country
China
ProdList
263
Advantage
62
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
9976
Advantage
60
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9310
Advantage
66
Accela ChemBio Co.,Ltd.
Tel
021-50795510 4000665055
Fax
021-50795055
Email
sales@accelachem.com
Country
China
ProdList
11035
Advantage
64
Shanghai Longsheng chemical Co.,Ltd.
Tel
021-58099652-8005 13585536065
Fax
021-58099609
Email
bin.wu@shlschem.com
Country
China
ProdList
9883
Advantage
59
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42934
Advantage
64
China DongFan Chemical Co.,LTD
Tel
86-0571-85151182
Fax
86-0571-85151182
Country
China
ProdList
5691
Advantage
66
Shanghai Ennopharm Co., Ltd.
Tel
+86 (21) 6435-5022
Country
China
ProdList
4267
Advantage
65
China Langchem Inc.
Tel
0086-21-58956006
Fax
0086-21-58956100
Country
China
ProdList
7811
Advantage
57
Nanjing Kaitian Chemical Co., Ltd.
Tel
+86 (25) 5860-8846
Fax
+86 (25) 5860-8846
Email
kt_chem@126.com
Country
China
ProdList
218
Advantage
62
SpringPharma Tech Co.,Ltd
Tel
+86-25-68710855, +86-25-68710897
Fax
025-68710856
Email
sales@springpharma.net
Country
China
ProdList
1261
Advantage
62
Shanghai Sunway Pharmaceutical Technology Co., Ltd
Tel
18270980682
Fax
021 51613951
Email
mlcheng@sunwaypharm.cn
Country
China
ProdList
8669
Advantage
57
Hangzhou Yuhao Chemical Technology Co., Ltd
Tel
0571-82693216
Fax
+86-571-82880190
Email
info@yuhaochemical.com
Country
China
ProdList
6387
Advantage
52
ZhengZhou HuaWen Chemical Co.Ltd
Tel
0370-2785118 17550508557
Fax
QQ：3470079902
Email
675141927@qq.com
Country
China
ProdList
3199
Advantage
55
Shanghai Sphchem Co., Ltd.
Tel
021-56491756 13512199871
Fax
021-5649-1756
Email
2819742715@qq.com
Country
China
ProdList
4000
Advantage
55
Wuhan Haizheng Industry & Trade Development Co. Ltd
Tel
027-8866 0053/88660577/88660578
Fax
027-8899 1911
Country
China
ProdList
1073
Advantage
55
Shanghai Topbiochem Technology Co., Ltd
Tel
021-58170097
Email
info@topbiochem.com
Country
China
ProdList
9510
Advantage
58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66113011 17798518460
Fax
(1)02557626880
Email
cfzhang@aikonchem.com
Country
China
ProdList
19913
Advantage
55
Shanghai Jian Chao Chemical Technology Co., Ltd.
Tel
150-2103-5486 18017383231
Fax
qq：2817624287
Email
983544897@qq.com
Country
China
ProdList
9342
Advantage
55
Ascepion Pharmaceuticals, Inc.
Tel
+86-512-86881668
Fax
+86-512-62956001
Country
China
ProdList
100
Advantage
58
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-6206333 13167063860
Fax
021-50323701
Email
anhua.mao@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
Shanghai Witofly Chemical Co.,Ltd
Tel
Email
sales@witofly.com
Country
China
ProdList
2864
Advantage
52
Shanghai Yolne Chemical Co., Ltd.
Tel
021-62960152
Fax
021-52212593
Email
934678158@qq.com
Country
China
ProdList
9899
Advantage
55
Shanghai Raise Chemical Technology Co.,Ltd
Tel
+86-021-50935922
Fax
+86-021-33847795
Country
China
ProdList
7865
Advantage
55
Chem-Stone Co.,Ltd.
Tel
020-82185713,82185709 13418171485
Fax
020-82185696
Email
sales@chem-stone.com
Country
China
ProdList
744
Advantage
56
Shanghai Huikai Chemical Technology Co., Ltd.
Tel
021-61995394 18916691159
Email
chemicalsea@163.com
Country
China
ProdList
1972
Advantage
58
Huainan Kedi Chemical Factory
Tel
0554-2106669
Fax
0554-2666215
Email
sales1@kedichem.com
Country
China
ProdList
4924
Advantage
55
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
39966
Advantage
60
Chemwill Asia Co.,Ltd.
Tel
86-21-51086038
Fax
86-21-51861608
Country
China
ProdList
2930
Advantage
58
Shanghai GaoLang Chemical Technology Co., Ltd.
Tel
021-57340939 18017297327
Fax
021-37210791
Email
sales@gaolangchemical.com
Country
China
ProdList
892
Advantage
55
Shanghai Worldyang Chemical Co.,Ltd.
Tel
021-021-56795766
Fax
+86-21-56795266
Email
sales@worldyachem.com
Country
China
ProdList
9476
Advantage
58
Chengdu HuaXia Chemical Reagent Co. Ltd
Tel
400-1166-196 13458535857
Fax
QQ：800101999
Email
cdhxsj@163.com
Country
China
ProdList
13350
Advantage
58
Wuxi Zhongkun Biochemical Technology Co., Ltd.
Tel
0510-85629785 18013409632
Fax
051085625359
Email
sales@reading-chemicals.com
Country
China
ProdList
15178
Advantage
58
Chemfun Medical Technology(Shanghai) Co., Ltd.
Tel
021-67220633 021-54824098
Fax
+86-21-54824069
Email
chemfun@chemfun.net
Country
China
ProdList
491
Advantage
58
Hunan HuaTeng Pharmaceutical Co., Ltd.,
Tel
400-8592883
Fax
0731-82251112
Email
sales@huatengsci.com
Country
China
ProdList
5872
Advantage
58
Changzhou Qinuo Chemical Co., Ltd.Co., Ltd.
Tel
0519-0519-83812535
Email
sales@qinuochem.com
Country
China
ProdList
287
Advantage
60
Credit-Chem Co., Ltd.
Tel
400-821-5857 021-64326257
Fax
021-64393586 QQ;2798200800
Email
credit-chem@foxmail.com
Country
China
ProdList
5219
Advantage
58
More
Less

View Lastest Price from 4-Amino-2-chloropyrimidine manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
4-Amino-2-chloropyrimidine 7461-50-9
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20T
Release date
2020-05-14
Zhuozhou Wenxi import and Export Co., Ltd
Product
4-Amino-2-chloropyrimidine 7461-50-9
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
4-Amino-2-chloropyrimidine 7461-50-9
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09

7461-50-9, 4-Amino-2-chloropyrimidineRelated Search:

4-Aminopyrimidine MCPA SODIUM 4-Aminoantipyrine 2-Chloropyrimidine 4,4'-Diaminodiphenylsulfone MCPB Glycine ALTRENOGEST Betaine 2-Aminobenzylchloride Difluorochloromethane 5-Chloropyrimidine-2,4,6-triamine 4-AMINO-2-CHLOROPYRIMIDINE-5-CARBONITRILE,4-AMINO-2-CHLOROPYRIMIDINE-5-CARBOXNITR&,4-Amino-2-chloropyrimidine-5-carbonitrile ,97% 4-Amino-6-chloropyrimidine-5-carboxaldehyde 2-AMINO-5-CHLOROPYRIMIDINE 2,4,5-Triamino-6-chloropyrimidine hydrochloride 4-AMINO-6-CHLOROPYRIMIDIN-5-YLAMINE N-(tert-Butyl)-6-chloropyrimidin-4-amine

  • 2-CHLOROPYRIMIDIN-4-AMINE
  • 2-CHLOROPYRIMIDIN-4-YLAMINE
  • 2-CHLORO-4-PYRIMIDINAMINE
  • 2-CHLORO-4-AMINOPYRIMIDINE
  • 4-Pyrimidinamine, 2-chloro- (9CI)
  • 4-AMINO-2-CHLOROPYRIMIDINE
  • 4-Pyrimidinamine, 2-chloro-
  • 4-Amino-2-chloropyrimidine ,97%
  • 4-Amino-2-chloropyrimidin...
  • 2-chloropyrimidin-4-amine7461-50-9
  • 2-Chloropyrimidin-4-amine, 4-Amino-2-chloro-1,3-diazine
  • 4-Amino-2-chloropyrimidine &gt
  • 4H-1-Benzopyran-4-one,6-bromo-2,3-dihydro-2,4-dimethyl-
  • Ethane,1-(2-bromoethoxy)-2-(7-methoxyethoxy)-
  • 7461-50-9
  • C4H4N3Cl
  • Building Blocks
  • Halogenated Heterocycles
  • Heterocyclic Building Blocks
  • Pyrimidines
  • PyrimidinesHeterocyclic Building Blocks
  • pharmacetical
  • Pyrimidine Derivertives
  • Heterocycle-Pyrimidine series
  • Pyridines
  • PYRIMIDINE
  • Pyridines, Pyrimidines, Purines and Pteredines