6-Fluoro-1-methyl-4-oxo-7-(1-piperazinyl)-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid

Product Name: 6-Fluoro-1-methyl-4-oxo-7-(1-piperazinyl)-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid
CAS No.: 112984-60-8
Chemical Name: 6-Fluoro-1-methyl-4-oxo-7-(1-piperazinyl)-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid
Synonyms: PL-11;NM 394;Panc327;PANC 327;PANC3.27;Panc3_27;Panc-327;Panc 3.27;Panc-3_27;ulifloxacin
CBNumber: CB6197108
Molecular Formula: C16H16FN3O3S
Formula Weight: 349.38
MOL File: 112984-60-8.mol

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6-Fluoro-1-methyl-4-oxo-7-(1-piperazinyl)-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid Property

Melting point:: 215-218 °C (decomp)
Boiling point:: 577.0±50.0 °C(Predicted)
Density: 1.58±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO (Sparingly), Methanol (Slightly)
form: Solid
pka: 5.85±0.40(Predicted)
color: Pale Yellow to Yellow
CAS DataBase Reference: 112984-60-8(CAS DataBase Reference)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: U700700
Product name: Ulifloxacin
Packaging: 100mg
Price: $110
Updated: 2021/12/16

TRC

Product number: U700700
Product name: Ulifloxacin
Packaging: 500mg
Price: $475
Updated: 2021/12/16

AK Scientific

Product number: I873
Product name: Ulifloxacin
Packaging: 5mg
Price: $19
Updated: 2021/12/16

AK Scientific

Product number: I873
Product name: Ulifloxacin
Packaging: 100mg
Price: $95
Updated: 2021/12/16

Matrix Scientific

Product number: 093686
Product name: 6-Fluoro-1-methyl-4-oxo-7-(piperazin-1-yl)-1,4-dihydro-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid
Purity: 95+%
Packaging: 250mg
Price: $319
Updated: 2021/12/16

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6-Fluoro-1-methyl-4-oxo-7-(1-piperazinyl)-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid Chemical Properties,Usage,Production

Chemical Properties

Yellow Solid

Uses

A metabolite of Prulifloxacin (P838885). Ulifloxacin is a new quinolone antibiotic and it is effective against pneumonia.

Uses

A labelled metabolite of Prulifloxacin (P838885). Ulifloxacin is a new quinolone antibiotic and it is effective against pneumonia.

Definition

ChEBI: Ulifloxacin is a member of quinolines.

Biological Activity

Ulifloxacin is an orally available, broad-spectrum fluoroquinolone antibacterial agent. Ulifloxacin is an active metabolite of Prulifloxacin. It potently inhibits bacterial DNA gyrase and topoisomerase IV.

Synthesis

113028-17-4

112984-60-8

The general procedure for the synthesis of 6-fluoro-1-methyl-4-oxo-7-(piperazin-1-yl)-1,4-dihydro-[1,3]thiazolo[3,2-a]quinoline-3-carboxylic acid from ethyl 6-fluoro-1-methyl-4-oxo-7-(1-piperazinyl)-1,4-dihydro-[1,3]thiazolo[3,2-a]quinoline-3-carboxylate was as follows: 1. ethyl 6-fluoro-1-methyl-4-oxo-7-(1-piperazinyl)-4H-[1,3]thiazolo[3,2-a]quinoline-3-carboxylate (100 g, 0.265 mol) was dissolved in water (600 ml) at 25-30 °C with stirring. 2. potassium hydroxide solution (50 g of potassium hydroxide flakes dissolved in 200 ml of water) was slowly added to this solution. 3. the reaction mixture is heated to 80-85°C and stirred at this temperature for 1 hour. 4. After completion of the reaction, the reaction mixture was cooled down to 25-30 °C. The reaction mixture was then cooled down to 25-30 °C. 5. The pH of the reaction mixture was adjusted to 6.5-7.0 using a 1:1 aqueous solution of acetic acid. 6. The reaction mixture was stirred at room temperature for 1 hour to allow the product to fully precipitate. 7. The precipitated solid was collected by filtration and washed with distilled water (2 x 100 mL). 8. The solid was slurried in methanol (300 ml) at 25-30 °C for 1 h. The reaction mixture was stirred for 1 h at room temperature. 9. After filtration, the solid was washed with methanol (2 x 50 ml). 10. The product was dried under vacuum at 70-75 °C to afford 6-fluoro-1-methyl-4-oxo-7-(piperazin-1-yl)-1,4-dihydro-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid (90 g, 97% yield, 96% HPLC purity).

References

[1] Patent: WO2012/1357, 2012, A1. Location in patent: Page/Page column 22
[2] Patent: CN103113392, 2016, B. Location in patent: Paragraph 0024; 0037; 0038; 0039
[3] Patent: CN107383069, 2017, A. Location in patent: Paragraph 0063; 0064
[4] Journal of Medicinal Chemistry, 1992, vol. 35, # 25, p. 4727 - 4738
[5] Patent: WO2009/93268, 2009, A1. Location in patent: Page/Page column 15

6-Fluoro-1-methyl-4-oxo-7-(1-piperazinyl)-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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6-Fluoro-1-methyl-4-oxo-7-(1-piperazinyl)-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid Suppliers

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View Lastest Price from 6-Fluoro-1-methyl-4-oxo-7-(1-piperazinyl)-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 6-Fluoro-1-methyl-4-oxo-7-(1-piperazinyl)-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid 112984-60-8
Price: US $25.00/KG
Min. Order: 100KG
Purity: 99.5%
Supply Ability: 100 mt
Release date: 2025-03-10

Career Henan Chemical Co

Product: 6-Fluoro-1-methyl-4-oxo-7-(1-piperazinyl)-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid 112984-60-8
Price: US $500.00/KG
Min. Order: 100G
Purity: 98%
Supply Ability: 10KG,20KG
Release date: 2018-07-25

112984-60-8, 6-Fluoro-1-methyl-4-oxo-7-(1-piperazinyl)-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acidRelated Search:

Methyl salicylate 1-Methylpiperazine Thiophanate-methyl Probucol N-Aminoethylpiperazine 2-Ethylhexyl ferulate Tribenuron methyl Piperacillin Quinclorac Quinoline Quinoline Yellow Methyl Methyl bromide Fluorine 3-Quinolinecarboxylic acid Ethyl 6-fluoro-1-methyl-4-oxo-7-(1-piprazinyl)-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylate Prulifloxacin 6-Fluoro-1-methyl-4-oxo-7-(1-piperazinyl)-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid

PRULIFLOXACIN INTERMEDIATE 3

6-FLUORO-1-METHYL-4-OXO-7-(1-PIPERAZINYL)-4H-(1,3)THIAZETO(3,2-A)QUINOLINE-3-CARBOXYLIC ACID

6-FLUORO-1-METHYL-4-OXO-7-PIPERAZIN-1-YL-4H-2-THIA-8B-AZA-CYCLOBUTA[A] NAPHTHALENE-3-CARBOXYLIC ACID

6-FLUORO-1-METHYL-4-OXO-7-(1-PIPRAZINYL)-4H-(1,3)-THIAZETO(3,2-A)QUINOLINE-3-CAR

1H,4H-[1,3]Thiazeto[3,2-a]quinoline-3-carboxylic acid, 6-fluoro-1-methyl-4-oxo-7-(1-piperazinyl)-

6-FLUORO-1-METHYL-4-OXO-7-(1-PIPRAZINYL)-1H,4H-(1,3)THIAZETO(3,2-A)QUINOLINE-3-CARBOXYLIC ACID

6-fluoro-1-methyl-4-oxo-7-(1-piperazinyl)-4H-(1,3)-thiazeto(3,2-a)quinoline-3-carboxylic acid cas:(intermediate of prulifloxacin)

6-FLUORO-1-METHYL-4-OXO-7-(1-PIPERAZINYL)-4H-(1,3)-HIAZETO(3,2-A)QUINOLINE-3-CARBOXYLIC ACID

6-FLUORO-7-PIPERAZINE-1-METHYL-4-OXY-[1,3]THIOAZACYCLIC[3,2-A]-QUINOLINE-3-CARBOXYLIC ACID

NM 394

6-Fluoro-1-Methyl-4-Oxo-7-(1-Piperazinyl)-4H-(1,3)-Thiazeto(3,2-Alpha)Quinoline-3-Carboxylic Acid

6-Fluoro-1-methyl-7-(1-piperazinyl)-4-oxo-4H-(1,3)thiazeto(3,2-a)quinoline-3-carboxylic acid

ulifloxacin

Prulifloxacin Intermediate PL-11

6-Fluro-1-methyl-4-oxo-7-(1-piperazinyl)-4H-(1,3)-thiazeto(3,2-a)quinoline-3-carboxylic Acid

PL-11 6-Fluoro-1-methyl-4-oxo-7-(1-piperazinyl)-4H- (1,3)-hiazeto(3,2-a)quinoline-3-carboxylic acid

6-Fluoro-1-methyl-4-oxo-7-(1-piperazinyl)-4H-(1,3)-thiazeto

6-Fluoro-1-Methyl-4-oxo-7-

6-Fluoro-1-methyl-4-oxo-7-(piperazin-1-yl)-1,4-dihydro-[1,3]thiazeto[3,2-a]quinoline-3-carboxy

6-Fluoro-1-Methyl-4-oxo-7-(piperazin-1-yl)-1,4-dihydro-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid

6-fluoro-1-Methyl-4-oxo- 7-(1-piperazinyl)-4H-(1,3) S,N-containing heterocyclic bi- (3,2-a) quinoline-3-carboxylic acid

PL-11

6-Fluoro-1-methyl-4-oxo-7-(piperazin-1-yl)-1,4-dihydro-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic

6-Fluoro-1-Methyl-4-Oxo-7-(1-Piperazinyl)-4H-[1,3]Thiazeto[3,2-A]Quinoline-3-Carboxylic Acid Pl-11

6-fluoro-1-methyl-4-oxo-7-(1-piperazinyl)-1H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid

Prulifloxacin intermediate III

Panc 03.27 Cells Line

Panc 3.27

PANC 327

PANC3.27

Panc3_27

Panc-3_27

Panc327

Panc-327

112984-60-8

C16H8D8FN3O3S

C16H16FN3O3S

C16H16N3O3FS

PRULIFLOXACIN

(intermediate of prulifloxacin)

Aromatics

Heterocycles

Intermediates & Fine Chemicals

Metabolites & Impurities

Pharmaceuticals

Sulfur & Selenium Compounds

Isotope Labelled Compounds

API intermediates

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