3-Methoxyphenol Property

Melting point:

-17 °C

Boiling point:

113-115 °C/5 mmHg (lit.)

Density 

1.131 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.552(lit.)

Flash point:

>230 °F

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

Chloroform (Slightly), Ethyl Acetate (Slightly)

form 

Liquid

pka

9.65(at 25℃)

color 

Clear pink-reddish to brown

Odor

at 1.00?%?in?dipropylene glycol. phenolic

Water Solubility 

slightly soluble

BRN 

1209898

InChIKey

ASHGTJPOSUFTGB-UHFFFAOYSA-N

LogP

1.340

CAS DataBase Reference

150-19-6(CAS DataBase Reference)

NIST Chemistry Reference

3-Methoxyphenol(150-19-6)

EPA Substance Registry System

Phenol, 3-methoxy- (150-19-6)

Safety

Hazard Codes 

Xn

Risk Statements 

20/21/22-36/38-41-36/37/38-43-36-22

Safety Statements 

26-36/37/39-46-37/39-24/25

RIDADR 

UN 2810 6.1/PG 3

WGK Germany 

3

RTECS 

SL7524000

TSCA 

Yes

HazardClass 

6.1

PackingGroup 

III

HS Code 

29095090

Toxicity

human,TCLo,inhalation,230ug/m3/22W (0.23mg/m3),BEHAVIORAL: IRRITABILITYBEHAVIORAL: MUSCLE WEAKNESSBEHAVIORAL: HEADACHE,Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 37(3), Pg. 108, 1972.

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H311Toxic in contact with skin

H315Causes skin irritation

H318Causes serious eye damage

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

3-Methoxyphenol Chemical Properties,Usage,Production

Chemical Properties

Clear pink red liquid

Uses

3-Methoxyphenol may be used as an analytical standard for the determination of the analyte in wine, coffee beans, wood samples, and mainstream smoke by gas chromatography (GC) based techniques.

Uses

A phenol derivative, 3-Methoxyphenol can be used as catalysts and as building blocks in synthesis of organic compounds such as antioxidants.

Preparation

synthesis of 3-methoxyphenol: The 1 mole of resorcinol is treated rapidly with stirring, in a three-necked flask provided with a reflux condenser, stirrer, internal thermometer, and dropping funnel, with 1.25 mole of 10% sodium hydroxide. With vigorous stirring, 1 mole of dimethyl sulfate is added in such a way that the temperature remains below 40° C (water cooling). To complete the reaction and to destroy unchanged dimethyl sulfate, the mixture is then heated for 30 min on a boiling water bath. After cooling, the organic layer is separated off and the aqueous solution is extracted several times with ether. The combined organic phases are washed with dilute sodium carbonate and then with water, dried with calcium chloride, and fractionated. Unchanged resorcinol can be recovered by acidifying the aqueous reaction solution and the wash water and extracting them with ether. The yield of 3-methoxyphenol is 50%, b.p. 113-115 °C/5 mm; b.p. 144°C/25mm; n20/D 1.552; d=1.131 g/mL at 25 °C.
Organicum. Practical Handbook of Organic Chemistry, by Heinz Becker, Werner Berger and Günter Domschke, Addison-Wesley Pub. Co, 206-207, (1973)

Definition

ChEBI: 3-methoxyphenol is a member of the class of phenols that is phenol having a methoxy-substituent at the 3-position. It is a member of phenols and a monomethoxybenzene. It derives from a resorcinol.

General Description

3-Methoxyphenol is a phenolic aroma compound typically present in food and beverage products.

Safety Profile

Poison by ingestion and intraperitoneal routes. Moderately toxic by skin contact. Human systemic effects by inhalation: muscle weakness, headache, and irritabdtty. Human female reproductive effects by inhalation: menstrual cycle changes and dsorders. A severe eye irritant. When heated to decomposition it emits acrid smoke and irritating fumes. See also ETHERS.