ChemicalBook > CAS DataBase List > Calenduloside E

Calenduloside E

Product Name: Calenduloside E
CAS No.: 26020-14-4
Chemical Name: Calenduloside E
Synonyms: C08964;Silphioside F;Calunduloside E;Calenduloside E;CALENDULOSIDE E (CE);Calendulaglycoside F;Oleanolic acid 3-glucuronide;Oleanoic acid 3-o-glucuronide;Oleanolic acid 3-O-glucuronide;Calenduloside E, 10 mM in DMSO
CBNumber: CB62077310
Molecular Formula: C36H56O9
Formula Weight: 632.82
MOL File: 26020-14-4.mol

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Calenduloside E Property

Melting point:: 243-245 °C (decomp)
Boiling point:: 750.8±60.0 °C(Predicted)
Density: 1.27±0.1 g/cm3(Predicted)
pka: 2.82±0.70(Predicted)
form: Solid
color: White to off-white
InChIKey: IUCHKMAZAWJNBJ-SJESXAJKNA-N

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: O521010
Product name: OleanolicAcid3-O-Glucuronide
Packaging: 10mg
Price: $165
Updated: 2021/12/16

TRC

Product number: O521010
Product name: OleanolicAcid3-O-Glucuronide
Packaging: 100mg
Price: $1320
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb594559
Product name: Calenduloside E
Packaging: 20mg
Price: $799
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC74357
Product name: Calenduloside E
Packaging: 25mg
Price: $850
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC74357
Product name: Calenduloside E
Packaging: 1mg
Price: $100
Updated: 2021/12/16

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Calenduloside E Chemical Properties,Usage,Production

Description

Calenduloside E (CE), a natural pentacyclic triterpenoid saponin, is a significant component of saponin isolated from the bark and root of Aralia elata (Miq.) ?AS are usually used as an antihypertensive, anti-arrhythmic and anti-diabetic agent in traditional Chinese medicine (Wang et al. 2014). In human umbilical vein endothelial cells (HUVECs), CE and CE analog can repress ox-LDL induced apoptosis (Tian et al. 2019).

Uses

Oleanolic Acid 3-O-Glucuronide exhibits hypoglycemic activities by suppressing the transfer of glucose from the stomach to the small intestine and by inhibiting glucose transport at the brush border of the small intestine in oral glucose-loaded rats.

Definition

ChEBI: Oleanolic acid 3-O-beta-D-glucosiduronic acid is a beta-D-glucosiduronic acid. It is functionally related to an oleanolic acid.

in vivo

Calenduloside E (11 mg/kg; i.g.; once daily for 16 weeks) reduces atherosclerotic plaque size, enhanced plaque stability, and reduced inflammatory responses in ApoE-/- mice^[2]. Calenduloside E (15 and 30 mg/kg; i.g.; once daily for 7 days) inhibits hepatocyte apoptosis and reduced oxidative stress and immune inflammation in mice with acute liver injury induced by LPS (HY-D1056) and D-GalN^[3]. Calenduloside E (7.5-30 mg/kg; i.g.; once daily for 3 days) restores sarcomere contraction and calcium transients in adult rat ventricular myocytes (ARVMs)^[4]. Calenduloside E (5 and 10 mg/kg; i.g.; once daily for 4 weeks) improves liver injury, lipid accumulation, and profibrotic phenotypes in nonalcoholic fatty liver disease model mice and inhibits inflammasome activation and pyroptosis in the liver of mice^[5].

Animal Model:	HFD-fed ApoE-/- mice^[2]
Dosage:	11 mg/kg
Administration:	i.g.；Once a day for 16 weeks
Result:	Reduced the levels of IL-1β, IL-6, TNF-α, and monocyte chemoattractant protein-1 (MCP-1) in the serum of ApoE-/- mice.

Animal Model:	LPS (HY-D1056)/dGalN-induced acute liver injury in mice^[3]
Dosage:	15 and 30 mg/kg
Administration:	i.g.; 1 time per day for 7 consecutive days
Result:	Improved hepatocyte infiltration and reduced hepatocyte necrosis and shrinkage. Reduced hepatocyte ROS levels and serum MDA levels, and increased GSH-Px and SOD levels.

Animal Model:	Rat Model of MI/R Injury^[4]
Dosage:	7.5, 15 and 30 mg/kg
Administration:	i.g.; 1 time per day for 3 consecutive days
Result:	Myocardial infarction area/risk area decreased to 53%, 38% and 43% respectively. Restored the expression of calcium-regulating proteins, including calcium transporters (SERCA, a1C, RyR2, and NCX) to normal levels.

Animal Model:	Establishment of NAFLD model in apoE-/- mice by western diet^[5]
Dosage:	5 and 10 mg/kg
Administration:	i.g.; 1 time per day for 4 weeks
Result:	Reduced the expression of TNF-α, MCP-1, CCL2, Ly6c and cd68 in the liver. Reversed the upregulation of lipogenic genes FASN, Srebpf, ACC and PPARγ and lipid uptake gene cd36. Reduced the expression of NLRP3, pNLRC4, NLRC4, cleaved GSDMD, cleaved Caspase1 and IL-1β.

References

[1] JIANXIONG LI. Calenduloside E alleviates cerebral ischemia/reperfusion injury by preserving mitochondrial function[J]. Journal of Molecular Histology, 2022, 53 4: 713-727. DOI:10.1007/s10735-022-10087-5.
[2] YIFEI LE . Calenduloside E ameliorates non-alcoholic fatty liver disease via modulating a pyroptosis-dependent pathway.[J]. Journal of ethnopharmacology, 2023, 319: Article 117239. DOI:10.1016/j.jep.2023.117239.
[3] LANFANG LI . Calenduloside e modulates macrophage polarization via KLF2-regulated glycolysis, contributing to attenuates atherosclerosis[J]. International immunopharmacology, 2023, 117: Article 109730. DOI:10.1016/j.intimp.2023.109730.
[4] RUIYING WANG . Calenduloside E suppresses calcium overload by promoting the interaction between L-type calcium channels and Bcl2-associated athanogene 3 to alleviate myocardial ischemia/reperfusion injury[J]. Journal of Advanced Research, 2021, 34: Pages 173-186. DOI:10.1016/j.jare.2020.10.005.
[5] MIN WANG. Calenduloside E Ameliorates Myocardial Ischemia-Reperfusion Injury through Regulation of AMPK and Mitochondrial OPA1.[J]. Oxidative Medicine and Cellular Longevity, 2020: 2415269. DOI:10.1155/2020/2415269.

Calenduloside E Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Calenduloside E manufacturers

Shanghai Standard Technology Co., Ltd.

Product: Calenduloside E 26020-14-4
Price: US $0.00/mg
Min. Order: 20mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2020-05-25

26020-14-4, Calenduloside ERelated Search:

Artemether Hydroxyecdysone beta-Eudesmol hydroxygenkwanin 2-(3,4-Dihydroxyphenyl)-8-(2-O-beta-L-galactopyranosyl-beta-D-glucopyranosyl)-5,7-dihydroxy-4H-1-Benzopyran-4-one MOSLOFLAVONE alpha-Terpineol alpha-Cyperone (4E,6E)-1,7-Diphenyl-4,6-heptadien-3-one beta-Sitosterol BUPLEURUM EXTRACT Gastrodin Ethylamine (-)-Varitriol araloside A GinsenosideRo MOMORDINIC Calenduloside E

17β-Carboxy-28-norolean-12-en-3β-yl β-D-glucopyranosiduronic acid

Calenduloside E

Oleanolic acid 3-glucuronide

Oleanolic acid 3-O-glucuronide

Oleanolic acid 3-β-D-glucuronoside

Silphioside F

C08964

Oleanoic acid 3-o-glucuronide

Calunduloside E

b-D-Glucopyranosiduronic acid,(3b)-17-carboxy-28-norolean-12-en-3-yl

CALENDULOSIDE E (CE)

β-D-Glucopyranosiduronic acid, (3β)-17-carboxy-28-norolean-12-en-3-yl

Inhibitor,Calenduloside E,inhibit,HSP,Heat shock proteins,Endogenous Metabolite

Calendulaglycoside F

Calenduloside E, 10 mM in DMSO

26020-14-4

Pentacyclic Triterpenes

reagent

standard substance