ChemicalBook > CAS DataBase List > 4-(Trifluoromethoxy)fluorobenzene

4-(Trifluoromethoxy)fluorobenzene

Product Name
4-(Trifluoromethoxy)fluorobenzene
CAS No.
352-67-0
Chemical Name
4-(Trifluoromethoxy)fluorobenzene
Synonyms
1-FLUORO-4-(TRIFLUOROMETHOXY)BENZENE;uoro-4-(trifL;P-FLUORO(TRIFLUOROMETHOXY)BENZENE;4-(TRIFLUOROMETHOXY)FLUOROBENZENE;4-FLUORO(TRIFLUOROMETHOXY)BENZENE;p-(Trifluoromethoxy)fluorobenzene;4- hydroxyl -3-Methyl acetophenone;4-(TRIFLUOROMETHOXY)-1-FLUORBENZENE;4-(Trifluoromethoxy)phenyl fluoride;4-Fluorophenyl trifluoromethyl ether
CBNumber
CB6209447
Molecular Formula
C7H4F4O
Formula Weight
180.1
MOL File
352-67-0.mol
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4-(Trifluoromethoxy)fluorobenzene Property

Boiling point:
104-105 °C(lit.)
Density 
1.323 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.394(lit.)
Flash point:
60 °F
storage temp. 
Store below +30°C.
form 
liquid
Specific Gravity
1.323
color 
Clear, colourless
Water Solubility 
Not miscible or difficult to mix in water.
BRN 
2046330
InChI
InChI=1S/C7H4F4O/c8-5-1-3-6(4-2-5)12-7(9,10)11/h1-4H
InChIKey
JULMJGDXANEQDP-UHFFFAOYSA-N
SMILES
C1(F)=CC=C(OC(F)(F)F)C=C1
CAS DataBase Reference
352-67-0(CAS DataBase Reference)
NIST Chemistry Reference
P-fluorophenyl trifluoromethyl ether(352-67-0)
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Safety

Hazard Codes 
F,Xi
Risk Statements 
11-36/37/38
Safety Statements 
16-26-36/37/39
RIDADR 
UN 1993 3/PG 2
WGK Germany 
3
Hazard Note 
Irritant
HazardClass 
3
PackingGroup 
II
HS Code 
29093090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.41175
Product name
4-(Trifluoromethoxy)-1-fluorobenzene
Purity
for synthesis
Packaging
1mL
Price
$108
Updated
2025/07/31
TRC
Product number
F598938
Product name
1-Fluoro-4-(trifluoromethoxy)benzene
Packaging
2.5g
Price
$65
Updated
2021/12/16
Apolloscientific
Product number
PC4370D
Product name
1-Fluoro-4-(trifluoromethoxy)benzene
Packaging
100g
Price
$67
Updated
2021/12/16
SynQuest Laboratories
Product number
2607-3-41
Product name
1-Fluoro-4-(trifluoromethoxy)benzene
Purity
99%
Packaging
100g
Price
$74
Updated
2021/12/16
Matrix Scientific
Product number
008766
Product name
4-(Trifluoromethoxy)fluorobenzene
Purity
98%
Packaging
100g
Price
$63
Updated
2021/12/16
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4-(Trifluoromethoxy)fluorobenzene Chemical Properties,Usage,Production

Uses

It is employed as an active pharmaceutical intermediate.

Synthesis

338792-64-6

352-67-0

The general procedure for the synthesis of p-fluorotrifluoromethoxybenzene from 2,2-difluoro-2-(4-fluorophenoxy)acetic acid was as follows: a stir bar was added to a 5 mL microwave vial in an argon-protected glove box and sealed. Selectfluor (177.1 mg, 0.5 mmol, 2.0 eq.), silver trifluoromethanesulfonate (12.8 mg, 0.05 mmol, 20 mol%), and 2,2-difluoro-2-(4-fluorophenoxy)acetic acid (0.25 mmol, 1.0 eq.) were added sequentially. The vial was charged with dichloromethane (1.8 mL), trifluoroacetic acid (76.5 μL, 1.0 mmol, 4.0 equiv) and water (0.2 mL). The reaction mixture was heated at 55 °C for 1 hour. After completion of the reaction, the mixture was cooled to room temperature, diluted with dichloromethane (4 mL), washed sequentially with water (3 x 5 mL) and brine (5 mL), dried over anhydrous magnesium sulfate and filtered. The dried organic phase was concentrated on a rotary evaporator. The crude product obtained was dissolved in a small amount of dichloromethane and purified by passing through a silica gel column (10 g, Biotage), first dried with air and then eluted with pentane. The fractions containing the pure product were combined and the solvent evaporated to give pure p-fluorotrifluoromethoxybenzene.

References

[1] Organic Letters, 2016, vol. 18, # 15, p. 3754 - 3757
[2] Organic Letters, 2016, vol. 18, # 18, p. 4570 - 4573
[3] Angewandte Chemie - International Edition, 2016, vol. 55, # 33, p. 9758 - 9762
[4] Angew. Chem., 2016, vol. 128, # 33, p. 9910 - 9914,5
[5] Journal of Fluorine Chemistry, 2017, vol. 203, p. 130 - 135

4-(Trifluoromethoxy)fluorobenzene Preparation Products And Raw materials

Raw materials

Preparation Products

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4-(Trifluoromethoxy)fluorobenzene Suppliers

Canada 1 China 165 Europe 2 France 1 Germany 5 India 2 Italy 1 Japan 2 South Korea 1 Switzerland 1 The Netherlands 1 Ukraine 1 United Kingdom 14 United States 28 Global 225
Melrob Ltd (part of Nordmann)
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View Lastest Price from 4-(Trifluoromethoxy)fluorobenzene manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
4-(Trifluoromethoxy)fluorobenzene 352-67-0
Price
US $0.00-0.00/KG
Min. Order
10mg
Purity
99%
Supply Ability
2000tons
Release date
2020-01-16
Career Henan Chemical Co
Product
4-(Trifluoromethoxy)fluorobenzene 352-67-0
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
Customized
Release date
2019-06-25

352-67-0, 4-(Trifluoromethoxy)fluorobenzeneRelated Search:

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  • 4-(trifluoromethoxy)fluorobenzene,1-fluoro-4-(trifluoromethoxy)benzene
  • p-(Trifluoromethoxy)fluorobenzene
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  • 1-(Trifluoromethoxy)-4-fluorobenzene
  • 4-(Trifluoromethoxy)phenyl fluoride
  • 4- hydroxyl -3-Methyl acetophenone
  • 4-(Trifluoromethoxy)-1-fluorobenzene for synthesis
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