Tert-buthyl Pitavastatin

Product Name: Tert-buthyl Pitavastatin
CAS No.: 586966-54-3
Chemical Name: Tert-buthyl Pitavastatin
Synonyms: Tert-butyl Pitavastatin;ert-Buthyl Pitavastatin;Tert-buthyl Pitavastatin;Pitavastatin t-Butyl Ester;Pitavastatin tert-Butyl Ester;pitavastatin-defluorination impurity;(3R,5S,E)-tert-butyl 7-(2-cyclopropyl-4-;5-dihydroxy-6-heptenoic acid tert-butyl ester;Pitavastatin Impurity 11(Pitavastatin t-Butyl Ester);6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3
CBNumber: CB62123321
Molecular Formula: C29H32FNO4
Formula Weight: 477.57
MOL File: 586966-54-3.mol

More

Less

Tert-buthyl Pitavastatin Property

Boiling point:: 674.5±55.0 °C(Predicted)
Density: 1.235±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Chloroform (Sligthly), Methanol (Slightly)
form: Solid
pka: 13.52±0.20(Predicted)
color: White to Off-White
InChIKey: RCARMBIYAHBUHR-UQECUQMJSA-N
SMILES: C(OC(C)(C)C)(=O)C[C@H](O)C[C@H](O)/C=C/C1=C(C2=CC=C(F)C=C2)C2C(N=C1C1CC1)=CC=CC=2

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

TRC

Product number: B695670
Product name: tert-ButylPitavastatin
Packaging: 50mg
Price: $105
Updated: 2021/12/16

TRC

Product number: B695670
Product name: tert-ButylPitavastatin
Packaging: 100mg
Price: $165
Updated: 2021/12/16

TRC

Product number: B695670
Product name: tert-ButylPitavastatin
Packaging: 500mg
Price: $495
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0079133
Product name: PITAVASTATIN TERT-BUTYL ESTER
Purity: 95.00%
Packaging: 5G
Price: $909.56
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0079133
Product name: PITAVASTATIN TERT-BUTYL ESTER
Purity: 95.00%
Packaging: 10G
Price: $1334.03
Updated: 2021/12/16

More

Less

Tert-buthyl Pitavastatin Chemical Properties,Usage,Production

Uses

tert-Butyl Pitavastatin is used to prepare hemicalcium salt.

Synthesis

147489-06-3

586966-54-3

Tert-butyl (4R,6S)-6-[[(1E)-2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]vinyl]-2,2-dimethyl-1,3-dioxane-4-acetate (1.5 kg) was used as raw material and dissolved in acetonitrile (16 L). A mixture of 35% HCl solution (0.91 kg) and purified water (9.5 kg) was slowly added under stirring conditions over a period of 2 hours. Stirring of the reaction mixture was continued for 1 hour. The progress of the reaction was monitored by HPLC and the reaction was terminated after confirming complete consumption of the raw material. The reaction mixture was neutralized with sodium bicarbonate and subsequently extracted with ethyl acetate. The organic layer was separated, washed with sodium chloride solution (1.5 kg) and concentrated under reduced pressure. The concentrated residue was dissolved in ethyl acetate (1.5 L) and hexane (9 L) was slowly added. The mixture was cooled to about 10 °C with continuous stirring for 2 hours. The precipitate was collected by filtration under reduced pressure and dried under reduced pressure at about 50 °C to afford the target product (3R,5S,E)-tert-butyl (3R,5S,E)-7-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-3,5-dihydroxyhept-6-enoate (1.22 kg) as white crystals in 88.4% yield.HPLC purity: 98.555%.

References

[1] Patent: US2013/72688, 2013, A1. Location in patent: Paragraph 0060-0062
[2] Patent: US2012/16129, 2012, A1. Location in patent: Page/Page column 13-14
[3] Patent: WO2014/108795, 2014, A2. Location in patent: Page/Page column 19; 20
[4] Patent: JP6231262, 2017, B2. Location in patent: Paragraph 0030-0032

Tert-buthyl Pitavastatin Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Tert-buthyl Pitavastatin Suppliers

China 127 India 5 United States 10 Global 142

BOC Sciences

Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 12952
Advantage: 65

BOC Sciences

Tel: 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 9923
Advantage: 65

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
Advantage: 58

Standardpharm Co. Ltd.

Tel: 86-714-3992388
Email: overseasales1@yongstandards.com
Country: United States
ProdList: 14332
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354;
Email: support@targetmol.com
Country: United States
ProdList: 39035
Advantage: 58

Alfa Chemistry

Tel: --
Fax: --
Email: info@Alfa-Chemistry.com
Country: United States
ProdList: 6814
Advantage: 0

United States Biological

Tel: --
Fax: --
Email: chemicals@usbio.net
Country: United States
ProdList: 6214
Advantage: 80

MedChemExpress

Tel: --
Fax: --
Email: sales@medchemexpress.com
Country: United States
ProdList: 6398
Advantage: 58

Matrix Scientific

Tel: --
Fax: --
Email: sales@matrixscientific.com
Country: United States
ProdList: 6632
Advantage: 80

NE Scientific

Tel: --
Fax: --
Country: United States
ProdList: 5030
Advantage: 55

More

Less

View Lastest Price from Tert-buthyl Pitavastatin manufacturers

Hefei Lbao Physical & Chemical Science Co.,Ltd

Product: Tert-buthyl Pitavastatin 586966-54-3
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: Customise
Release date: 2025-10-09

Hangzhou ICH Biofarm Co., Ltd

Product: Tert-buthyl Pitavastatin 586966-54-3
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200
Release date: 2023-07-12

Zhuozhou Wenxi import and Export Co., Ltd

Product: Tert-buthyl Pitavastatin 586966-54-3
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-26

586966-54-3, Tert-buthyl PitavastatinRelated Search:

Tert-buthyl Pitavastatin

(3R,5S,6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptenoic acid tert-butyl ester

Pitavastatin tert-Butyl Ester

7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptenoic acid tert-butyl ester

pitavastatin-defluorination impurity

(3R,5S,6E)7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolyl]-3,5-dihydrosy-6-heptaneacid,ethylester

Tert-butyl Pitavastatin

Pitavastatin t-Butyl Ester

(3R,5S,E)-tert-Butyl 7-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-3,5-dihydroxyhept-6-eno

(3R,5S,6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl) quinolin-3-yl]-3,5-dihydroxyhept-6-enoic acid t-butyl ester

Pitavastatin Impurity 11(Pitavastatin t-Butyl Ester)

5-dihydroxy-6-heptenoic acid tert-butyl ester

6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3

(3R,5S,E)-tert-butyl 7-(2-cyclopropyl-4-

tert-butyl (3R,5S,E)-7-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-3,5-dihydroxyhept-6-enoate

6-Heptenoic acid, 7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-, 1,1-dimethylethyl ester, (3R,5S,6E)-

sodium (3R,5S,E)-7-(2-cyclopropyl-4-(4-fluorophenyl)-1- oxidoquinolin-3-yl)-3,5-dihydroxyhept-6-enoate

ert-Buthyl Pitavastatin

(3R,5S,Z)-Tert-butyl 7-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-3,5-dihydroxyhept-6-enoate (Pitavastatin Impurity)

Ethyl7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptanoate

586966-54-3

C29H32FNO4

Other APIs