5-METHYL-2-(TRIFLUOROMETHYL)ANILINE

5-METHYL-2-(TRIFLUOROMETHYL)ANILINE Property

Boiling point:

207.2±35.0 °C(Predicted)

Density 

1.237±0.06 g/cm3(Predicted)

storage temp. 

2-8°C, protect from light

pka

1.59±0.10(Predicted)

Appearance

Yellow to brown Liquid

Water Solubility 

Slightly soluble in water.

Safety

Hazard Codes 

Xn

Risk Statements 

20/21/22-36/37/38-22

Safety Statements 

26-36/37/39

RIDADR 

2810

HazardClass 

6.1

HS Code 

2921420090

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H331Toxic if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

5-METHYL-2-(TRIFLUOROMETHYL)ANILINE Chemical Properties,Usage,Production

Synthesis

Step 1: 4-methyl-2-nitro-1-trifluoromethylbenzene (1 g, 4.8 mmol) and 30 mL of methanol were added to a 100 mL reaction vial. Pd/C catalyst (0.2 g, 10% content) was then added. The reaction mixture was stirred under hydrogen atmosphere (1 atm, 25°C) for 4 hours. Upon completion of the reaction, the reaction solution was filtered to remove the catalyst and the filtrate was concentrated. The residue was purified by column chromatography (eluent: ethyl acetate/petroleum ether = 1:10) to afford 2-amino-4-methylbenzotrifluoride (0.68 g, 80% yield). Mass spectrometry analysis: [M+1]+ 176.2.

References

[1] Patent: EP3150592, 2017, A1. Location in patent: Paragraph 0133; 0134; 0135
[2] Bioorganic and Medicinal Chemistry Letters, 2015, vol. 25, # 17, p. 3738 - 3743