Sodium phosphate monobasic
- Product Name
- Sodium phosphate monobasic
- CAS No.
- 7558-80-7
- Chemical Name
- Sodium phosphate monobasic
- Synonyms
- Monosodium phosphate;Sodium phosphate monobasic anhydrous;SODIUMMONOBASICPHOSPHATE;Sodium Phosphate Monbasic;MONOSODIUM PHOSPHATE (MSP);Monosodium dihydrogen phosphate;Sodium dihydrogenorthophosphate;SODIUMSALTSOFORTHOPHOSPHORICACID;SODIUM DIHYDROGEN PHOSPHATE-16O4;monosodiumdihydrogenorthophosphate
- CBNumber
- CB6219354
- Molecular Formula
- H3O4P.Na
- Formula Weight
- 119.977
- MOL File
- 7558-80-7.mol
Sodium phosphate monobasic Property
- Melting point:
- <0°C
- Boiling point:
- 100°C
- Density
- 1.40 g/mL at 20 °C
- vapor pressure
- 0Pa at 20℃
- storage temp.
- room temp
- solubility
- H2O: 5 M, clear, colorless
- form
- powder
- color
- White
- PH
- 4.0 - 4.5 (25℃, 50g/L in water)
- pka
- (1) 2.15, (2) 6.82, (3) 12.38 (at 25℃)
- Odor
- at 100.00?%. odorless
- Water Solubility
- Soluble in water. Insoluble in alcohol,ether and chloroform.
- Sensitive
- Hygroscopic
- λmax
- λ: 260 nm Amax: ≤0.025
λ: 280 nm Amax: ≤0.02 - Merck
- 14,8660
- BRN
- 3903772
- Stability:
- Stable. Incompatible with heavy metals, strong acids.
- InChIKey
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M
- LogP
- -2.148 (est)
- CAS DataBase Reference
- 7558-80-7(CAS DataBase Reference)
- EPA Substance Registry System
- Monosodium phosphate (7558-80-7)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38-36
- Safety Statements
- 26-36-39
- WGK Germany
- 1
- RTECS
- WA1900000
- F
- 3
- TSCA
- Yes
- HS Code
- 28352200
- Hazardous Substances Data
- 7558-80-7(Hazardous Substances Data)
- Toxicity
- LD50 orally in Rabbit: 8290 mg/kg LD50 dermal Rabbit > 7940 mg/kg
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 74092
- Product name
- Sodium phosphate monobasic solution
- Purity
- BioUltra, 5?M in H2O
- Packaging
- 100mL
- Price
- $96.1
- Updated
- 2024/03/01
- Product number
- 74092
- Product name
- Sodium phosphate monobasic solution
- Purity
- BioUltra, 5?M in H2O
- Packaging
- 500mL
- Price
- $333
- Updated
- 2024/03/01
- Product number
- 1.06370
- Product name
- Sodium dihydrogen phosphate
- Purity
- anhydrous99.99Suprapur?
- Packaging
- 50g
- Price
- $290
- Updated
- 2024/03/01
- Product number
- 1.06370
- Product name
- Sodium dihydrogen phosphate
- Purity
- anhydrous99.99Suprapur?
- Packaging
- 250g
- Price
- $502
- Updated
- 2024/03/01
- Product number
- 229903
- Product name
- Sodium phosphate monobasic
- Purity
- 99.999% trace metals basis
- Packaging
- 10g
- Price
- $128
- Updated
- 2023/01/07
Sodium phosphate monobasic Chemical Properties,Usage,Production
Chemical Properties
White, slightly deliquescent crystals or granules.
Chemical Properties
The USP 32 states that monobasic sodium phosphate contains one
or two molecules of water of hydration or is anhydrous.
The hydrated forms of monobasic sodium phosphate occur as
odorless, colorless or white, slightly deliquescent crystals. The
anhydrous form occurs as a white crystalline powder or granules.
Physical properties
Anhydrous salt: white crystalline powder; slightly hygroscopic; forms sodium acid pyrophosphate, Na2H2P2O7 on heating above 225°C and sodium metaphosphate (NaPO3)n at about 350 to 400°C; very soluble in water, aqueous solution acidic.
Monohydrate: white orthorhombic crystals or granules; density 2.04 g/cm3; loses its water of crystallization at 100°C; very soluble in water, pH of 1% solution 4.5; insoluble in alcohol.
Dihydrate: large transparent crystals; orthorhombic bisphenoidal structure; density 1.915 g/cm3; decomposes at 60°C; very soluble in water; insoluble in alcohol.
Uses
Sodium phosphate monobasic monohydrate is used as sequestrant, emulsifier, mordant in dyeing, reagent and buffer in foods and analytical chemistry. It was applied as a fireproofing agent and for weighting silk in tanning. It is employed in manufacturing of enamels, ceramics, detergents, boiler compounds, in soldering and brazing instead of borax.
Uses
Sodium phosphate monobasic has been used:
- as a reagent for virus transfection and fiber implantation in mouse
- in phosphate buffer for immunocytochemistry and to detect individual catalase activity by PAGE (polyacrylamide gel electrophoresis)
- as a buffer for cycling assay
- in automated DNA extraction method
- as a chemical in artificial cerebro-spinal fluid (aCSF) solution for the preparation of brainstem-spinal cord from rats
Uses
Excipient.
Production Methods
Monobasic sodium phosphate is prepared by adding phosphoric acid to a hot, concentrated solution of disodium phosphate until the liquid ceases to form a precipitate with barium chloride. This solution is then concentrated and the monobasic sodium phosphate is crystallized.
Definition
ChEBI: Sodium dihydrogenphosphate is a sodium phosphate.
Preparation
Monobasic sodium phosphate can be prepared by partial neutralization of phosphoric acid with sodium hydroxide in equimolar amounts: H3PO4 + NaOH → NaH2PO4 + H2O
It also can be made by treating disodium hydrogen phosphate with phosphoric acid in proper stoichiometric amount: Na2HPO4 + HPO4 → 2NaH2PO4.
General Description
Sodium phosphate monobasic is an effective oral osmotic laxative at minimal concentration. It is used for colonic cleansing before endoscopic examination of colon.
Flammability and Explosibility
Non flammable
Pharmaceutical Applications
Monobasic sodium phosphate is used in a wide variety of
pharmaceutical formulations as a buffering agent and as a
sequestering agent. Therapeutically, monobasic sodium phosphate
is used as a mild saline laxative and in the treatment of hypophosphatemia.
Monobasic sodium phosphate is also used in food products, for
example, in baking powders, and as a dry acidulant and
sequestrant.
Safety Profile
Poison by intramuscular route. Mdly toxic by ingestion. A human and experimental eye irritant. When heated to decomposition it emits toxic fumes of POx and Na2O. See also PHOSPHATES.
Safety
Monobasic sodium phosphate is widely used as an excipient in
parenteral, oral, and topical pharmaceutical formulations.
Phosphate occurs extensively in the body and is involved in
many physiological processes since it is the principal anion of
intracellular fluid. Most foods contain adequate amounts of
phosphate, making hypophosphatemia virtually unknown except
in certain disease states or in patients receiving total parenteral
nutrition. Treatment is usually by the oral administration of up to
100 mmol of phosphate daily.
Approximately two-thirds of ingested phosphate is absorbed
from the gastrointestinal tract, virtually all of it being excreted in the
urine, and the remainder is excreted in the feces.
Excessive administration of phosphate, particularly intravenously,
rectally, or in patients with renal failure, can cause
hyperphosphatemia that may lead to hypocalcemia or other severe
electrolyte imbalances. Adverse effects occur less frequently
following oral consumption, although phosphates act as mild saline
laxatives when administered orally or rectally (2–4 g of monobasic
sodium phosphate in an aqueous solution is used as a laxative).
Consequently, gastrointestinal disturbances including diarrhea,
nausea, and vomiting may occur following the use of monobasic
sodium phosphate as an excipient in oral formulations. However,
the level of monobasic sodium phosphate used as an excipient in a pharmaceutical formulation is not usually associated with adverse
effects.
LD50 (rat, IM): 0.25 g/kg(10)
LD50 (rat, oral): 8.29 g/kg
storage
Monobasic sodium phosphate is chemically stable, although it is
slightly deliquescent. On heating at 100°C, the dihydrate loses all of
its water of crystallization. On further heating, it melts with
decomposition at 205℃, forming sodium hydrogen pyrophosphate,
Na2H2P2O7. At 250℃ it leaves a final residue of sodium
metaphosphate, NaPO3.
Aqueous solutions are stable and may be sterilized by autoclaving.
Monobasic sodium phosphate should be stored in an airtight
container in a cool, dry place.
Incompatibilities
Monobasic sodium phosphate is an acid salt and is therefore
generally incompatible with alkaline materials and carbonates;
aqueous solutions of monobasic sodium phosphate are acidic and
will cause carbonates to effervesce.
Monobasic sodium phosphate should not be administered
concomitantly with aluminum, calcium, or magnesium salts since
they bind phosphate and could impair its absorption from the
gastrointestinal tract. Interaction between calcium and phosphate,
leading to the formation of insoluble calcium phosphate precipitates,
is possible in parenteral admixtures.
Regulatory Status
GRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (injections; infusions; ophthalmic, oral, topical, and vaginal preparations). Included in nonparenteral and parenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.
Sodium phosphate monobasic Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Sodium phosphate monobasic manufacturers
- Product
- Sodium phosphate monobasic 7558-80-7
- Price
- US $100.00-75.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 5000Ton
- Release date
- 2024-08-13
- Product
- Sodium phosphate monobasic 7558-80-7
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20ton
- Release date
- 2024-05-23
- Product
- Sodium phosphate monobasic 7558-80-7
- Price
- US $0.00/KG
- Min. Order
- 25KG
- Purity
- 98%min
- Supply Ability
- 30tons/month
- Release date
- 2023-02-07