(1aR,4E,10aR)-1a,3,6,10a-Tetrahydro-1a,5,9-trimethyloxireno[4,5]cyclodeca[1,2-b]furan-10(2H)-one

Product Name: (1aR,4E,10aR)-1a,3,6,10a-Tetrahydro-1a,5,9-trimethyloxireno[4,5]cyclodeca[1,2-b]furan-10(2H)-one
CAS No.: 7727-79-9
Chemical Name: (1aR,4E,10aR)-1a,3,6,10a-Tetrahydro-1a,5,9-trimethyloxireno[4,5]cyclodeca[1,2-b]furan-10(2H)-one
Synonyms: Zederone;(1aR,4E,10aR)-1a,3,6,10a-Tetrahydro-1a,5,9-trimethyloxireno[4,5]cyclodeca[1,2-b]furan-10(2H)-one;Oxireno[4,5]cyclodeca[1,2-b]furan-10(2H)-one, 1a,3,6,10a-tetrahydro-1a,5,9-trimethyl-, (1aR,4E,10aR)-
CBNumber: CB62238944
Molecular Formula: C15H18O3
Formula Weight: 246.3
MOL File: 7727-79-9.mol

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(1aR,4E,10aR)-1a,3,6,10a-Tetrahydro-1a,5,9-trimethyloxireno[4,5]cyclodeca[1,2-b]furan-10(2H)-one Property

Melting point:: 153.4-153.9℃ (acetone hexane )
solubility: Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form: Powder
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Biosynth Carbosynth

Product number: FZ156853
Product name: Zederone
Packaging: 1mg
Price: $100
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FZ156853
Product name: Zederone
Packaging: 2mg
Price: $150
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FZ156853
Product name: Zederone
Packaging: 5mg
Price: $250
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FZ156853
Product name: Zederone
Packaging: 10mg
Price: $320
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FZ156853
Product name: Zederone
Packaging: 25mg
Price: $650
Updated: 2021/12/16

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(1aR,4E,10aR)-1a,3,6,10a-Tetrahydro-1a,5,9-trimethyloxireno[4,5]cyclodeca[1,2-b]furan-10(2H)-one Chemical Properties,Usage,Production

Uses

Zederone, a germacrane-type sesquiterpene, has potently cytotoxic against human white blood cancer cells and human prostate cancer cells. Zederone significantly inhibits the proliferation and downregulates the protein expressions of mTOR, and phosphorylated p70 S6 kinase (p-p70s6K) in SKOV3 cells[1][2].

target

TNF-α | Nrf2 | NADPH-oxidase | P450 (e.g. CYP17) | Antifection

IC 50

mTOR

References

[1] Prapapan Pimkaew, et al. Zederone, a sesquiterpene from Curcuma elata Roxb, is hepatotoxic in mice. Int J Toxicol. 2013 Nov-Dec;32(6):454-62. DOI:10.1177/1091581813504595
[2] Zhilei Zhang, et al. A study of zederone for the inhibition on ovarian cancer cell proliferation through mTOR/p70s6K signalling pathway. J BUON. 2020 Mar-Apr;25(2):785-791. PMID:32521868

(1aR,4E,10aR)-1a,3,6,10a-Tetrahydro-1a,5,9-trimethyloxireno[4,5]cyclodeca[1,2-b]furan-10(2H)-one Preparation Products And Raw materials

Raw materials

Preparation Products

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(1aR,4E,10aR)-1a,3,6,10a-Tetrahydro-1a,5,9-trimethyloxireno[4,5]cyclodeca[1,2-b]furan-10(2H)-one Suppliers

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7727-79-9, (1aR,4E,10aR)-1a,3,6,10a-Tetrahydro-1a,5,9-trimethyloxireno[4,5]cyclodeca[1,2-b]furan-10(2H)-oneRelated Search:

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(1aR,4E,10aR)-1a,3,6,10a-Tetrahydro-1a,5,9-trimethyloxireno[4,5]cyclodeca[1,2-b]furan-10(2H)-one

Zederone

Oxireno[4,5]cyclodeca[1,2-b]furan-10(2H)-one, 1a,3,6,10a-tetrahydro-1a,5,9-trimethyl-, (1aR,4E,10aR)-

7727-79-9