N'-NITROSONORNICOTINE Property

Melting point:

47.1°C

Boiling point:

309.13°C (rough estimate)

Density 

1.1669 (rough estimate)

refractive index 

1.6500 (estimate)

storage temp. 

Hygroscopic, Refrigerator, Under Inert Atmosphere

solubility 

Chloroform (Slightly), Methanol (Slightly)

form 

Solid

pka

5.16±0.12(Predicted)

color 

Off-White to Pale Beige

Stability:

Stable, but air and light sensitive. Incompatible with oxidizing agents.

IARC

1 (Vol. Sup 7, 89, 100E) 2012

EPA Substance Registry System

N-Nitrosonornicotine (16543-55-8)

Safety

Hazard Codes 

Xn

Risk Statements 

36/37/38-40

Safety Statements 

26-36

RIDADR 

2810

HazardClass 

6.1(b)

PackingGroup 

III

Hazardous Substances Data

16543-55-8(Hazardous Substances Data)

Toxicity

LD50 intraperitoneal in mouse: 1gm/kg

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

N'-NITROSONORNICOTINE Chemical Properties,Usage,Production

Description

A nicotine alkaloid, this base has been detected in some Japanese cigarette tobaccos and also in Kirsu tobacco where it occurs in the fresh leaves that have been dried without fermentation. From these two sources it has been isolated at 1.1 and 1. 8 ppm levels respectively

Chemical Properties

white crystals

Uses

A tobacco alkaloid as risk factor of human cancer.

General Description

White crystalline flakes or yellow oil that solidifies on standing in the cold.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

A nitrated amine, nicotine derivative. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.

Health Hazard

ACUTE/CHRONIC HAZARDS: When heated to decomposition it may emit toxic and hazardous fumes of NOx and COx.

Fire Hazard

Flash point data for N'-NITROSONORNICOTINE are not available; however, N'-NITROSONORNICOTINE is probably combustible.

Safety Profile

Confirmed carcinogen with experimental carcinogenic, neoplastigenic, and tumorigenic data. Low toxicity by intraperitoneal route. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx. See also N-NITROSO COMPOUNDS.

Carcinogenicity

N-Nitrosonornicotine is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.

References

Bharadwaj et al., Gann., 66, 585 (1975)