ChemicalBook > CAS DataBase List > Magnolignan
Magnolignan
- Product Name
- Magnolignan
- CAS No.
- 20601-85-8
- Chemical Name
- Magnolignan
- Synonyms
- Magnolignan;Magnolignan, ≥98%;Tetrahydromagnolol;Tetrahydromagnolol Exclusive;5,5'-Dipropylbiphenyl-2,2'-diol;5,5'-Dipropyl-2,2'-biphenyldiol;5,5'-Dipropyl-[1,1'-biphenyl]-2,2'-diol;[1,1'-Biphenyl]-2,2'-diol, 5,5'-dipropyl-;2-Hydroxy-2'-hydroxy-5,5'-dipropyl-1,1'-biphenyl;Magnolignan,metabolite,Inhibitor,inhibit,Tetrahydromagnolol,Magnolol,CB2,GPR55,Cannabinoid Receptor,G protein-coupled receptor 55
- CBNumber
- CB62296195
- Molecular Formula
- C18H22O2
- Formula Weight
- 270.37
- MOL File
- 20601-85-8.mol
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Magnolignan Property
- Melting point:
- 144.5 °C
- Boiling point:
- 165.5-166 °C(Press: 2 Torr)
- Density
- 1.080±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- ≤20mg/ml in ethanol;16mg/ml in DMSO;20mg/ml in dimethyl formamide
- form
- crystalline solid
- pka
- 9.26±0.43(Predicted)
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N-Bromosuccinimide Price
Cayman Chemical
- Product number
- 14234
- Product name
- Tetrahydromagnolol
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $44
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 14234
- Product name
- Tetrahydromagnolol
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $84
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 14234
- Product name
- Tetrahydromagnolol
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $172
- Updated
- 2024/03/01
ApexBio Technology
- Product number
- C5552
- Product name
- Tetrahydromagnolol
- Packaging
- 25mg
- Price
- $194
- Updated
- 2021/12/16
ApexBio Technology
- Product number
- C5552
- Product name
- Tetrahydromagnolol
- Packaging
- 10mg
- Price
- $92
- Updated
- 2021/12/16
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Magnolignan Chemical Properties,Usage,Production
Biological Activity
tetrahydromagnolol is a major metabolite of magnolol and acts as a peripheral cb2 receptor agonist. tetrahydromagnolol also acts as an antagonist at gpr55 [1].cannabinoid (cb) receptors belong to the g protein-coupled receptor (gpcr) superfamily and are divided into cb1 and cb2. cb1 activation mediates analgesia, stimulation of appetite, and euphoria, among other effects. cb2 receptor activation results in analgesic and antiinflammatory effects. gpr55, a cb-related orphan receptor, is reported to interact with certain cbs [1].tetrahydromagnolol is a highly selective peripheral cb2 receptor agonist that is 19-fold more potent than magnolol with ec50 and ki values of 0.17 μm and 0.42 μm, respectively. magnolol is a bioactive compound isolated from the bark of magnolia officinalis that is used in asian traditional medicine for the treatment of anxiety, sleeping disorders, and allergic diseases. magnolol behaved as a partial agonist with selectivity for the cb2 subtype (ec50 = 3.28 μm; ki = 1.44 μm). in β-arrestin translocation assay, tetrahydromagnolol inhibited lpi-induced gpr55 activation with kb value of 13.3 μm [1].
References
[1]. rempel v, fuchs a, hinz s, et al. magnolia extract, magnolol, and metabolites: activation of cannabinoid cb2 receptors and blockade of the related gpr55. acs med chem lett. 2012 nov 14;4(1):41-5.
Magnolignan Preparation Products And Raw materials
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Preparation Products
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View Lastest Price from Magnolignan manufacturers
Career Henan Chemical Co
- Product
- 5,5'-Dipropyl-2,2'-biphenyldiol 20601-85-8
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ＞98%
- Supply Ability
- 20 tons
- Release date
- 2020-02-10
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