ChemicalBook > CAS DataBase List > Magnolignan

Magnolignan

Product Name: Magnolignan
CAS No.: 20601-85-8
Chemical Name: Magnolignan
Synonyms: Magnolignan;Magnolignan, ≥98%;Tetrahydromagnolol;Tetrahydromagnolol Exclusive;5,5'-Dipropylbiphenyl-2,2'-diol;5,5'-Dipropyl-2,2'-biphenyldiol;Tetrahydromagnolol, 10 mM in DMSO;5,5'-Dipropyl-[1,1'-biphenyl]-2,2'-diol;[1,1'-Biphenyl]-2,2'-diol, 5,5'-dipropyl-;2-Hydroxy-2'-hydroxy-5,5'-dipropyl-1,1'-biphenyl
CBNumber: CB62296195
Molecular Formula: C18H22O2
Formula Weight: 270.37
MOL File: 20601-85-8.mol

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Magnolignan Property

Melting point:: 144.5 °C
Boiling point:: 165.5-166 °C(Press: 2 Torr)
Density: 1.080±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: ≤20mg/ml in ethanol;16mg/ml in DMSO;20mg/ml in dimethyl formamide
form: crystalline solid
pka: 9.26±0.43(Predicted)
color: White to off-white
InChI: InChI=1S/C18H22O2/c1-3-5-13-7-9-17(19)15(11-13)16-12-14(6-4-2)8-10-18(16)20/h7-12,19-20H,3-6H2,1-2H3
InChIKey: OYAQUBKYAKSHOA-UHFFFAOYSA-N
SMILES: C1(C2=CC(CCC)=CC=C2O)=CC(CCC)=CC=C1O

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 14234
Product name: Tetrahydromagnolol
Purity: ≥98%
Packaging: 5mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 14234
Product name: Tetrahydromagnolol
Purity: ≥98%
Packaging: 10mg
Price: $84
Updated: 2024/03/01

Cayman Chemical

Product number: 14234
Product name: Tetrahydromagnolol
Purity: ≥98%
Packaging: 25mg
Price: $172
Updated: 2024/03/01

ChemScene

Product number: CS-0066137
Product name: Tetrahydromagnolol
Packaging: 1mg
Price: $70
Updated: 2021/12/16

ApexBio Technology

Product number: C5552
Product name: Tetrahydromagnolol
Packaging: 10mg
Price: $92
Updated: 2021/12/16

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Magnolignan Chemical Properties,Usage,Production

Uses

Tetrahydromagnolol (Magnolignan), the main metabolite of Magnolol, is a potent and selective cannabinoidCB2 receptor agonist (EC50 =170 nM) and GPR55 antagonist. The Ki of Tetrahydromagnolol for CB2 is 416 nM, 20-fold higher than for the CB1 receptor. Magnolol shows antifungal, anti-inflammatory and analgesic effects[1][2][3][4].

Biological Activity

tetrahydromagnolol is a major metabolite of magnolol and acts as a peripheral cb2 receptor agonist. tetrahydromagnolol also acts as an antagonist at gpr55 [1].cannabinoid (cb) receptors belong to the g protein-coupled receptor (gpcr) superfamily and are divided into cb1 and cb2. cb1 activation mediates analgesia, stimulation of appetite, and euphoria, among other effects. cb2 receptor activation results in analgesic and antiinflammatory effects. gpr55, a cb-related orphan receptor, is reported to interact with certain cbs [1].tetrahydromagnolol is a highly selective peripheral cb2 receptor agonist that is 19-fold more potent than magnolol with ec50 and ki values of 0.17 μm and 0.42 μm, respectively. magnolol is a bioactive compound isolated from the bark of magnolia officinalis that is used in asian traditional medicine for the treatment of anxiety, sleeping disorders, and allergic diseases. magnolol behaved as a partial agonist with selectivity for the cb2 subtype (ec50 = 3.28 μm; ki = 1.44 μm). in β-arrestin translocation assay, tetrahydromagnolol inhibited lpi-induced gpr55 activation with kb value of 13.3 μm [1].

IC 50

CB2: 170 nM (EC₅₀); CB2: 416 nM (Ki); CB1: 9010 nM (EC₅₀); CB1: 2260 nM (Ki); GPR55 receptor

References

[1]. rempel v, fuchs a, hinz s, et al. magnolia extract, magnolol, and metabolites: activation of cannabinoid cb2 receptors and blockade of the related gpr55. acs med chem lett. 2012 nov 14;4(1):41-5.

Magnolignan Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Magnolignan manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: Tetrahydromagnolol 20601-85-8
Price: US $3.00-9.00/KG
Min. Order: 0.1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2025-06-21

Career Henan Chemical Co

Product: 5,5'-Dipropyl-2,2'-biphenyldiol 20601-85-8
Price: US $9.80/KG
Min. Order: 1g
Purity: ＞98%
Supply Ability: 20 tons
Release date: 2020-02-10

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Tetrahydromagnolol

Tetrahydromagnolol Exclusive

[1,1'-Biphenyl]-2,2'-diol, 5,5'-dipropyl-

2-Hydroxy-2'-hydroxy-5,5'-dipropyl-1,1'-biphenyl

5,5'-Dipropylbiphenyl-2,2'-diol

Magnolignan

5,5'-Dipropyl-2,2'-biphenyldiol

5,5'-Dipropyl-[1,1'-biphenyl]-2,2'-diol

Magnolignan, ≥98%

Magnolignan,metabolite,Inhibitor,inhibit,Tetrahydromagnolol,Magnolol,CB2,GPR55,Cannabinoid Receptor,G protein-coupled receptor 55

Tetrahydromagnolol, 10 mM in DMSO

20601-85-8