U-73122
- Product Name
- U-73122
- CAS No.
- 112648-68-7
- Chemical Name
- U-73122
- Synonyms
- U-73312;U-73122;CS-1793;CS-2400;U-73122 98%;U 73122;U-73122;CAS:112648-68-7;U-73122 hydrate;U-73122 USP/EP/BP;U-73122, 10 mM in DMSO
- CBNumber
- CB6237598
- Molecular Formula
- C29H40N2O3
- Formula Weight
- 464.64
- MOL File
- 112648-68-7.mol
U-73122 Property
- Boiling point:
- 617.1±55.0 °C(Predicted)
- Density
- 1.16±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- ethanol: 0.7 mg/mL
- form
- solid
- pka
- 10.69±0.40(Predicted)
- color
- off-white
- Water Solubility
- Soluble in DMSO, ethanol, or DMF at approx. 0.5mg/ml. May require heating or overnight mixing. Insoluble in water
- Stability:
- Stable for 1 year from date of purchase as supplied. Use caution when storing DMSO solutions. Typically solutions in DMSO can be stored at -20°C for approximately 2 months. However, any solutions that turn pink should be discarded.
- InChIKey
- LUFAORPFSVMJIW-PFQOISFUNA-N
- SMILES
- [C@@]12([H])CCC3C=C(OC)C=CC=3[C@@]1([H])CC[C@]1(C)[C@H](CC[C@@]21[H])NCCCCCCN1C(=O)C=CC1=O |&1:0,12,16,18,21,r|
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- U6756
- Product name
- U-73122 hydrate
- Purity
- powder
- Packaging
- 5mg
- Price
- $170.05
- Updated
- 2025/07/31
- Product number
- 662035
- Product name
- U-73122
- Packaging
- 5mg
- Price
- $177
- Updated
- 2025/07/31
- Product number
- 70740
- Product name
- U-73122
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $21
- Updated
- 2024/03/01
- Product number
- 70740
- Product name
- U-73122
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $79
- Updated
- 2024/03/01
- Product number
- 70740
- Product name
- U-73122
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $118
- Updated
- 2024/03/01
U-73122 Chemical Properties,Usage,Production
Description
U-
Uses
It is used as a phospholipase C, phospholipase A2, and 5-LO inhibitor. It is also determined that in SK-N-SH neuroblastoma cells, U-73122 inhibits agonist-induced down-regulation of muscarinic receptors. In addition, it is a useful tool to investigate receptor-mediated PI turnover in signal transduction. U-73122 is a potent inhibitor of human neutrophil adhesion to biological surfaces (IC50 = 50 nM) as well as adhesion-dependent granule exocytosis and oxidative burst. U-73343 (sc-201422) is useful as a negative control for investigations of U-73122 phospholipase C antagonism and its cellular consequences.
Definition
ChEBI: An aza-steroid that is 3-O-methyl-17beta-estradiol in which the 17beta-hydroxy group is replaced by a 6-(maleimid-1-yl)hexylamino group. An inibitor of phospholipase C.
Biological Activity
Phospholipase C inhibitor. Inhibits agonist-induced platelet aggregation with IC 50 values of 1-5 μ M. Potently inhibits human polymorphonuclear neutrophil adhesion on biological surfaces (IC 50 < 50 nM) and exhibits antinociceptive activity in vivo .
Biochem/physiol Actions
Inhibits the hydrolysis of PPI to IP3, which leads to a decrease in cytosolic free calcium. Inhibits the coupling of G protein-phospholipase C activation, while remaining unaffected by production of cAMP.
storage
Store at RT
References
[1] J E BLEASDALE. Selective inhibition of receptor-coupled phospholipase C-dependent processes in human platelets and polymorphonuclear neutrophils.[J]. Journal of Pharmacology and Experimental Therapeutics, 1990, 255 2: 756-768.
[2] ALEXANDER V ZHOLOS. Phospholipase C, but not InsP3 or DAG, -dependent activation of the muscarinic receptor-operated cation current in guinea-pig ileal smooth muscle cells[J]. British Journal of Pharmacology, 2009, 141 1: 23-36. DOI:10.1038/sj.bjp.0705584
[3] YOUNGSOO JUN William W Rutilio A Fratti. Diacylglycerol and its formation by phospholipase C regulate Rab- and SNARE-dependent yeast vacuole fusion.[J]. The Journal of Biological Chemistry, 2004: 53186-53195. DOI:10.1074/jbc.m411363200
[4] INÉS FERNÁNDEZ-ULIBARRI. Diacylglycerol is required for the formation of COPI vesicles in the Golgi-to-ER transport pathway.[J]. Molecular Biology of the Cell, 2007, 18 9: 3250-3263. DOI:10.1091/mbc.e07-04-0334
U-73122 Preparation Products And Raw materials
Raw materials
Preparation Products
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