3-Chloro-5-fluorophenylboronic acid
- Product Name
- 3-Chloro-5-fluorophenylboronic acid
- CAS No.
- 328956-61-2
- Chemical Name
- 3-Chloro-5-fluorophenylboronic acid
- Synonyms
- AKOS BRN-0721;"328956-61-2 ";CAS:328956-61-2;3-Borono-5-fluorochlorobenzene;3-Chloro-5-fluorobenzeneboroni;3-CHLORO-5-FLUOROPHENYLBORONIC ACID;3-Chloro-5-fluorophenlyboronic acid;3-chloro-5-fluorophenylborinic acid;3-CHLORO-5-FLUOROBENZENEBORONIC ACID;3-Chloro-5-fluorobenzeneboronicacid97%
- CBNumber
- CB6243205
- Molecular Formula
- C6H5BClFO2
- Formula Weight
- 174.37
- MOL File
- 328956-61-2.mol
3-Chloro-5-fluorophenylboronic acid Property
- Melting point:
- >200°C
- Boiling point:
- 308.1±52.0 °C(Predicted)
- Density
- 1.41±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- soluble in Methanol
- form
- powder to crystal
- pka
- 6.52±0.10(Predicted)
- color
- White to Almost white
- Water Solubility
- Slightly soluble in water.
- CAS DataBase Reference
- 328956-61-2(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 22-36/37/38
- Safety Statements
- 26-36
- HazardClass
- IRRITANT
- HS Code
- 29163990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- C2914
- Product name
- 3-Chloro-5-fluorophenylboronic Acid (contains varying amounts of Anhydride)
- Packaging
- 1g
- Price
- $37
- Updated
- 2025/07/31
- Product number
- C2914
- Product name
- 3-Chloro-5-fluorophenylboronic Acid (contains varying amounts of Anhydride)
- Packaging
- 5g
- Price
- $145
- Updated
- 2025/07/31
- Product number
- C584618
- Product name
- 3-Chloro-5-fluorophenylboronicacid
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- C584618
- Product name
- 3-Chloro-5-fluorophenylboronicacid
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 6660-7-X1
- Product name
- 3-Chloro-5-fluorobenzeneboronic acid
- Purity
- 97%
- Packaging
- 1g
- Price
- $26
- Updated
- 2021/12/16
3-Chloro-5-fluorophenylboronic acid Chemical Properties,Usage,Production
Chemical Properties
White solid
Uses
3-Chloro-5-fluorobenzeneboronic acid is used as an important raw material and intermediate used in organic Synthesis, pharmaceuticals, agrochemicals and dyestuff.
Uses
suzuki reaction
Synthesis
121-43-7
33863-76-2
328956-61-2
Grignard's reagent was prepared by dissolving 11.3 g of dried magnesium shavings and 75.0 g of 1-bromo-3-chloro-5-fluorobenzene (S1-1) in 220 ml of anhydrous tetrahydrofuran (THF) under nitrogen protection. The reaction system was cooled to -70 °C and 52.0 g of trimethyl borate dissolved in 200 ml of THF was slowly added dropwise. The reaction temperature of -70°C was maintained and stirred for 3 hours. Subsequently, the reaction system was gradually warmed to room temperature and stirring was continued for 12 hours. Upon completion of the reaction, 2N hydrochloric acid was slowly added dropwise to the reaction solution and stirred for 1 hour. The reaction mixture was extracted with ethyl acetate, the organic phase was washed with water and dried over anhydrous sodium sulfate. The solvent was removed by distillation under reduced pressure and the residue was washed with heptane to give 34.7 g of 3-chloro-5-fluorophenylboronic acid (S1-2) in 55.7% yield.
References
[1] Patent: EP2433923, 2012, A1. Location in patent: Page/Page column 68
3-Chloro-5-fluorophenylboronic acid Preparation Products And Raw materials
Raw materials
Preparation Products
3-Chloro-5-fluorophenylboronic acid Suppliers
- Tel
- --
- Fax
- --
- sales-in@tcichemicals.com
- Country
- India
- ProdList
- 6768
- Advantage
- 58
- Tel
- --
- Fax
- --
- tech@alfa.com
- Country
- India
- ProdList
- 6905
- Advantage
- 58
- Tel
- --
- Fax
- --
- sales@ajchem.in
- Country
- India
- ProdList
- 6100
- Advantage
- 58
View Lastest Price from 3-Chloro-5-fluorophenylboronic acid manufacturers
- Product
- 3-Chloro-5-fluorophenylboronic acid 328956-61-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg; 5kg; 100kg
- Release date
- 2019-07-03