RESIQUIMOD
- Product Name
- RESIQUIMOD
- CAS No.
- 144875-48-9
- Chemical Name
- RESIQUIMOD
- Synonyms
- R0197;VML600;CS-2796;VML 600;VML-600;Leisimot;resquimod;resiquimo;RESIQUIMOD;Chebi:36706
- CBNumber
- CB62446527
- Molecular Formula
- C17H22N4O2
- Formula Weight
- 314.38
- MOL File
- 144875-48-9.mol
RESIQUIMOD Property
- Melting point:
- 190-193°
- Boiling point:
- 553.6±50.0 °C(Predicted)
- Density
- 1.28
- storage temp.
- -20°C
- solubility
- DMSO: soluble10mg/mL, clear (warmed to 60 °C)
- form
- powder
- pka
- 14.63±0.29(Predicted)
- color
- white to tan
- λmax
- 325nm(lit.)
- Merck
- 14,8151
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
- InChIKey
- BXNMTOQRYBFHNZ-UHFFFAOYSA-N
Safety
- WGK Germany
- 3
- RTECS
- NJ5911320
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H350May cause cancer
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313IF exposed or concerned: Get medical advice/attention.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- SML0196
- Product name
- Resiquimod
- Purity
- ≥98% (HPLC)
- Packaging
- 10mg
- Price
- $127
- Updated
- 2024/03/01
- Product number
- SML0196
- Product name
- Resiquimod
- Purity
- ≥98% (HPLC)
- Packaging
- 50mg
- Price
- $505
- Updated
- 2024/03/01
- Product number
- R0197
- Product name
- Resiquimod
- Purity
- >98.0%(HPLC)
- Packaging
- 25mg
- Price
- $106
- Updated
- 2024/03/01
- Product number
- R0197
- Product name
- Resiquimod
- Purity
- >98.0%(HPLC)
- Packaging
- 100mg
- Price
- $312
- Updated
- 2024/03/01
- Product number
- 14806
- Product name
- R-848
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $49
- Updated
- 2024/03/01
RESIQUIMOD Chemical Properties,Usage,Production
Description
Resiquimod (CAS 144875-48-9) is a Toll-like receptor 7/8 agonist.1 May be used as an immune adjuvant in cancer vaccines.2 Resiquimod-carrying synthetic vaccine particles augment the immune response to encapsulated antigen and exhibit strong local immune activation without inducing systemic cytokine release.3 Topical treatment of wild-type mice induces systemic autoimmune disease which may be used as a model of systemic Lupus erythematosus.4? It displayed potent antiviral activity (EC50 = 23.5 nM) in a murine norovirus replicon model.5
Uses
Resiquimod is an imidazoquinoline derivative that acts as an immune response modifier. Resiquimod shows antitumor and antiviral activity and is used in the treatment of skin lesions such as herpes simplex virus. Resiquimod is a toll-like receptor 9 (TLR7) agonist.
Uses
Resiquimod has been used in the stimulation of bone marrow-derived dendritic cells (BMDCs) stimulation( and B cells. It has also been used as a ligand for toll-like receptors (TLR7) in malignant melanoma cell line B16F10.
Definition
ChEBI: Resiquimod is an imidazoquinoline.
Biochem/physiol Actions
Resiquimod belongs to the class of imidazoquinolinamines compounds with immunomodulatory effects. Resiquimod increases the levels of cytokines such as TNF-α, IL-6 and IFN-α.
storage
Store at +4°C
References
1) Jurk et al. (2002), Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848; Nat. Immunol., 3 499 2) Sabado et al. (2015), Resiquimod as an immunologic adjuvant for NY-ESO-1 protein vaccination in patients with high-risk melanoma; Cancer Immunol. Res., 3 278 3) Ilyinskii et al. (2014), Adjuvant-carrying synthetic vaccine particles augment the immune response to encapsulated antigen and exhibit strong local immune activation without inducing systemic cytokine release; Vaccine, 32 2882 4) Yokogawa et al. (2014), Epicutaneous application of toll-like receptor 7 agonists leads to systemic autoimmunity in wild-type mice: a new model of systemic Lupus erthematosus; Arthritis Rheumatol., 66 694 5) Tuipulotu et al. (2018), TLR7 Agonists Display Potent Antiviral Effects against Norovirus Infection via Innate Stimulation; Antimicrob. Agents Chemother., 62 e02417
RESIQUIMOD Preparation Products And Raw materials
Raw materials
Preparation Products
RESIQUIMOD Suppliers
- Tel
- --
- Fax
- --
- service@merckgroup.com
- Country
- Germany
- ProdList
- 43
- Advantage
- 58
View Lastest Price from RESIQUIMOD manufacturers
- Product
- RESIQUIMOD 144875-48-9
- Price
- US $120.00/g
- Min. Order
- 100g
- Purity
- 99.99%
- Supply Ability
- 5ton/Month
- Release date
- 2021-11-26
- Product
- Resiquimod 144875-48-9
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- Resiquimod 144875-48-9
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09