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TOMEGLOVIR

Product Name
TOMEGLOVIR
CAS No.
233254-24-5
Chemical Name
TOMEGLOVIR
Synonyms
TOMEGLOVIR;BAY 38-4766;tomeglovir cas;Tomeglovir (BAY-38-4766);N-[4-[[[5-(Dimethylamino)-1-naphthalenyl]sulfonyl]amino]phenyl]-2-(hydroxymethyl)-2-methylpropanamide;Propanamide, N-[4-[[[5-(dimethylamino)-1-naphthalenyl]sulfonyl]amino]phenyl]-2-(hydroxymethyl)-2-methyl-
CBNumber
CB62451318
Molecular Formula
C23H27N3O4S
Formula Weight
441.54
MOL File
233254-24-5.mol
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TOMEGLOVIR Property

Density 
1.334±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO : ≥ 108 mg/mL (244.60 mM)
form 
Solid
pka
8.96±0.50(Predicted)
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0027853
Product name
Tomeglovir
Purity
99.45%
Packaging
5mg
Price
$110
Updated
2021/12/16
ChemScene
Product number
CS-0027853
Product name
Tomeglovir
Purity
99.45%
Packaging
10mg
Price
$150
Updated
2021/12/16
ChemScene
Product number
CS-0027853
Product name
Tomeglovir
Purity
99.45%
Packaging
25mg
Price
$300
Updated
2021/12/16
ChemScene
Product number
CS-0027853
Product name
Tomeglovir
Purity
99.45%
Packaging
50mg
Price
$480
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0019436
Product name
TOMEGLOVIR
Purity
95.00%
Packaging
5MG
Price
$500.25
Updated
2021/12/16
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TOMEGLOVIR Chemical Properties,Usage,Production

Biological Activity

Tomeglovir is an anti-CMV agent that inhibits the progression of viral DNA concatemers with IC50 values of 0.34 μM and 0.039 μM for HCMV and MCMV, respectively.

in vitro

Tomeglovir (BAY 38-4766) is a potent anti-CMV agent, with IC 50 s of 0.34 μM and 0.039 μM for HCMV and MCMV. Tomeglovir also suppresses HELF and NIH 3T3 cells, with CC 50 s of 85 μM and 62.5 μM, respectively. Tomeglovir (BAY 38-4766) inhibits HCMV Davis and various monkey CMV strains with EC 50 s of 1.03 ± 0.57 μM and < 1 μM.

in vivo

Tomeglovir (BAY 38-4766; 3, 10, 30, 100 mg/kg, po) dose-dependently reduces MCMV-DNA in salivary glands, livers and kidneys of MCMV-infected NOD-SCID mice, and prolongs the survival of the mice. It (10, 25 and 50 mg/kg) shows antiviral activity in the hollow fiber mouse model. Tomeglovir (BAY 38-4766) shows antiviral activity in SCID mice with MCMV, and the LD 50 is >2000 mg/kg in mice and rats.

target

IC50: 0.34 μM (HCMV), 0.039 μM (MCMV)

TOMEGLOVIR Preparation Products And Raw materials

Raw materials

Preparation Products

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TOMEGLOVIR Suppliers

China 31 United States 4 Global 35
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Country
United States
ProdList
9923
Advantage
65
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
TargetMol Chemicals Inc.
Tel
+8613564774135
Email
zijue.cai@tsbiochem.com
Country
United States
ProdList
19885
Advantage
58
MedChemExpress
Tel
--
Fax
--
Email
sales@medchemexpress.com
Country
United States
ProdList
6398
Advantage
58

233254-24-5, TOMEGLOVIRRelated Search:

9-(2-Hydroxyethyl)guanine Valaciclovir MONO-DESACETYL FAMCICLOVIR Famciclovir Related Compound A (20 mg) (2-[2-(2-Amino-9H-purin-9-yl)ethyl]propane-1,3-diol hydrochloride) L-Valine 2-Hydroxyethyl Ester 4-Methylbenzenesulfonate N-ForMyl Valacyclovir acyclovir triphosphate FAMCICLOVIR-D4 9-(2'-ACETOXYETHOXYMETHYL)-GUANINE N-Methyl Valganciclovir Hydrochloride Acyclovir IMpurity C N-t-Boc-valacyclovir 2-[2-(2-AMINO-9H-PURIN-9-YL)ETHYL]-1,3-PROPANEDIOL Valganciclovir Famciclovir Valganciclovir hydrochloride Valaciclovir EP Impurity H TOMEGLOVIR

  • TOMEGLOVIR
  • N-[4-[[[5-(Dimethylamino)-1-naphthalenyl]sulfonyl]amino]phenyl]-2-(hydroxymethyl)-2-methylpropanamide
  • BAY 38-4766
  • Tomeglovir (BAY-38-4766)
  • Propanamide, N-[4-[[[5-(dimethylamino)-1-naphthalenyl]sulfonyl]amino]phenyl]-2-(hydroxymethyl)-2-methyl-
  • tomeglovir cas
  • 233254-24-5