2-CHLORO-4-FLUORONICOTINIC ACID
Application- Product Name
- 2-CHLORO-4-FLUORONICOTINIC ACID
- CAS No.
- 929022-76-4
- Chemical Name
- 2-CHLORO-4-FLUORONICOTINIC ACID
- Synonyms
- 2-CHLORO-4-FLUORONICOTINIC ACID;2-Chloro-4-fluoro-3-pyridinecarboxylic acid;3-Pyridinecarboxylic acid, 2-chloro-4-fluoro-;tert-butyl 3-allyl-3-hydroxyazetidine-70-carboxylate
- CBNumber
- CB62455275
- Molecular Formula
- C6H3ClFNO2
- Formula Weight
- 175.54
- MOL File
- 929022-76-4.mol
2-CHLORO-4-FLUORONICOTINIC ACID Property
- Boiling point:
- 302.1±37.0 °C(Predicted)
- Density
- 1.576±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -0.46±0.25(Predicted)
- Appearance
- Off-white to light brown Solid
- InChI
- InChI=1S/C6H3ClFNO2/c7-5-4(6(10)11)3(8)1-2-9-5/h1-2H,(H,10,11)
- InChIKey
- GXDFQGOVWALHAS-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC=CC(F)=C1C(O)=O
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 4H21-7-11
- Product name
- 2-Chloro-4-fluoropyridine-3-carboxylic acid
- Purity
- 96%
- Packaging
- 250mg
- Price
- $203
- Updated
- 2021/12/16
- Product number
- PC201376
- Product name
- 2-Chloro-4-fluoronicotinicacid
- Purity
- 97%
- Packaging
- 1g
- Price
- $203
- Updated
- 2021/12/16
- Product number
- 4H21-7-11
- Product name
- 2-Chloro-4-fluoropyridine-3-carboxylic acid
- Purity
- 96%
- Packaging
- 1g
- Price
- $420
- Updated
- 2021/12/16
- Product number
- PC201376
- Product name
- 2-Chloro-4-fluoronicotinicacid
- Purity
- 97%
- Packaging
- 5g
- Price
- $580
- Updated
- 2021/12/16
- Product number
- 1651AJ
- Product name
- 2-Chloro-4-fluoronicotinicacid
- Packaging
- 25g
- Price
- $996
- Updated
- 2021/12/16
2-CHLORO-4-FLUORONICOTINIC ACID Chemical Properties,Usage,Production
Application
2-Chloro-4-fluoronicotinic acid is a carboxylic acid derivative that can be used to prepare glucocorticoid receptor ligands.
Synthesis
34941-91-8
124-38-9
929022-76-4
Step A: Synthesis of 2-chloro-4-iodopyridine-3-carboxylic acid (64-2) 1. In a dry reaction flask, LDA (97 mL, 1.8 M in heptane/THF/ethylbenzene, 175 mmol) was mixed with THF (304 mL) and the solution was cooled to -78°C. 2. 2-Chloro-4-fluoropyridine (20.0 g, 152 mmol) was dissolved in 2-chloro-4-iodopyridine-3-carboxylic acid (64-2). 2. 2-chloro-4-fluoropyridine (20.0 g, 152 mmol) was dissolved in THF (50 mL) and slowly added dropwise to the cooled LDA solution described above through a constant pressure dropping funnel over 20 minutes. 3. After the dropwise addition was completed, the reaction mixture was continued to be stirred at -78°C for 1 hour. 4. the reaction mixture was slowly poured into a container with dry ice and allowed to sublimate completely. 5. Water was added to the residue and the pH was adjusted to alkaline with 1N NaOH solution. 6. Extract the mixture with ether (Et2O) and discard the organic layer. 7. The aqueous layer was acidified to pH < 7 with 1N HCl solution and extracted with ethyl acetate (EtOAc). 8. The organic phases were combined, washed with saturated brine, dried over anhydrous magnesium sulfate (MgSO4) and concentrated under reduced pressure to give the orange solid product 64-2 (19 g, 71.2% yield). MS (ESI): m/z = 176.0 ([M+H]+).
References
[1] Patent: WO2011/53574, 2011, A1. Location in patent: Page/Page column 44
2-CHLORO-4-FLUORONICOTINIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
2-CHLORO-4-FLUORONICOTINIC ACID Suppliers
- Tel
- 13812573443
- Fax
- -
- tongbenwan22@163.com
- Country
- China
- ProdList
- 1980
- Advantage
- 55
- Tel
- 021-50795510 4000665055
- sy-c6@accelachem.com
- Country
- China
- ProdList
- 10000
- Advantage
- 58
- Tel
- 15221991309
- 315346700@qq.com
- Country
- China
- ProdList
- 97
- Advantage
- 58
- Tel
- 13526569071
- sales@leadmedpharm.com
- Country
- China
- ProdList
- 7892
- Advantage
- 64
- Tel
- 022-58013646 13011382049
- Fax
- 022-23854368
- sales@jinyudachem.com
- Country
- China
- ProdList
- 1930
- Advantage
- 55
- Tel
- 021-58170097
- info@topbiochem.com
- Country
- China
- ProdList
- 9510
- Advantage
- 58
- Tel
- 18652989687
- Fax
- +86-25-52131256
- sales@norris-pharm.com
- Country
- China
- ProdList
- 8878
- Advantage
- 55
- Tel
- 0319-5801333-8008 15630992918
- sales@summedchem.com
- Country
- China
- ProdList
- 965
- Advantage
- 58
- Tel
- 0515-89701588 13770166955
- Fax
- 0515-87400189
- orgunion@orgunion.com
- Country
- China
- ProdList
- 620
- Advantage
- 55
- Tel
- 400-164-7117 13681763483
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 39966
- Advantage
- 60
View Lastest Price from 2-CHLORO-4-FLUORONICOTINIC ACID manufacturers
- Product
- 2-CHLORO-4-FLUORONICOTINIC ACID 929022-76-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1000KGS
- Release date
- 2019-12-25