ChemicalBook > CAS DataBase List > C8-HSL

C8-HSL

Product Name
C8-HSL
CAS No.
147852-84-4
Chemical Name
C8-HSL
Synonyms
OHL;C8-HSL;Octanoyl-L-hoMoserine lactone;N-OCTANOYL-L-HOMOSERINE LACTONE;(3R)-3-(2-Oxononyl)Oxolan-2-One;N-[(3S)-2-oxooxolan-3-yl]octanamide;(S)-N-(2-Oxotetrahydrofuran-3-yl)octanamide;C8-HSL, OHL, N-Octanoyl-L-hoMoserine lactone;N-Octanoyl-L-homoserine lactone >=96% (HPLC);N-[(3S)-Tetrahydro-2-oxo-3-furanyl]octanamide
CBNumber
CB62456373
Molecular Formula
C12H21NO3
Formula Weight
227.3
MOL File
147852-84-4.mol
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C8-HSL Property

Melting point:
134-135 °C
Boiling point:
448.1±34.0 °C(Predicted)
Density 
1.04±0.1 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
DMF: 25 mg/ml; DMF:PBS(pH7.2) 1:2: 0.3 mg/ml; DMSO: 20 mg/ml
form 
A crystalline solid
pka
14.83±0.20(Predicted)
optical activity
[α]/D -28±3°, c = 0.2 in methanol
BRN 
8148282
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
44558
Product name
N-Octanoyl-L-homoserine lactone
Purity
≥96% (HPLC)
Packaging
10mg
Price
$166
Updated
2024/03/01
Sigma-Aldrich
Product number
44558
Product name
N-Octanoyl-L-homoserine lactone
Purity
≥96% (HPLC)
Packaging
50mg
Price
$776
Updated
2024/03/01
Cayman Chemical
Product number
10011199
Product name
N-octanoyl-L-Homoserine lactone
Purity
≥98%
Packaging
5mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
10011199
Product name
N-octanoyl-L-Homoserine lactone
Purity
≥98%
Packaging
10mg
Price
$84
Updated
2024/03/01
Cayman Chemical
Product number
10011199
Product name
N-octanoyl-L-Homoserine lactone
Purity
≥98%
Packaging
25mg
Price
$193
Updated
2024/03/01
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C8-HSL Chemical Properties,Usage,Production

Uses

Octanoyl-L-homoserine lactone is an active quorum sensing modulator first recognised in Yersinia pseudotuberculosis. Octanoyl-L-homoserine lactone and other acylhomoserine lactones have been detected in hundreds of bacterial species and, while the homologues vary between species and strains, the homoserine lactones are the major chemical modulators of within and between cell communication and regulation. The most significant variable defining the function of the homoserine lactone is the length of the acyl chain, with shorter chains displaying opposing actions to the longer chains.

General Description

N-Octanoyl-L-homoserine lactone (C8-HSL) is a N-acyl homoserine lactone (N-acyl-HSL). It is highly nonpolar.

Biochem/physiol Actions

N-Octanoyl-L-homoserine lactone is a member of N-acyl-homoserine lactone family. N-Acylhomoserine lactones (AHL) regulate gene expression in gram-negative bacteria, such as Echerichia and Salmonella, and are involved in quorum sensing, colonization, chemical defense and cell to cell communication among bacteria; for reviews see. AHLs are released as oligopeptides in Gram positive bacteria and as quorum signal in Gram negative bacteria. Bacterial intercellular communication has become a target for the development of new anti-virulence drugs, and a research focus for the prevention of biofilm formation.

C8-HSL Preparation Products And Raw materials

Raw materials

Preparation Products

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C8-HSL Suppliers

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147852-84-4, C8-HSLRelated Search:


  • N-OCTANOYL-L-HOMOSERINE LACTONE
  • OHL
  • C8-HSL, OHL, N-Octanoyl-L-hoMoserine lactone
  • Octanoyl-L-hoMoserine lactone
  • N-[(3S)-Tetrahydro-2-oxo-3-furanyl]octanamide
  • N-[(3S)-2-oxooxolan-3-yl]octanamide
  • C8-HSL
  • Octanamide, N-[(3S)-tetrahydro-2-oxo-3-furanyl]-
  • N-Octanoyl-L-homoserine lactone >=96% (HPLC)
  • (3R)-3-(2-Oxononyl)Oxolan-2-One
  • (S)-N-(2-Oxotetrahydrofuran-3-yl)octanamide
  • 147852-84-4