ChemicalBook > CAS DataBase List > CX-4945

CX-4945

Product Name
CX-4945
CAS No.
1009820-21-6
Chemical Name
CX-4945
Synonyms
CX-4945;CS-1985;Silmitasertib;CX-4945, >=98%;CX-4945, CX4945;mitasertib (CX-4945);SPIROBIINDANE CX-4945;Silmitasertib(CX-4945);CX-4945 Silmitasertib;CX-4945 Silmitasertib CX4945
CBNumber
CB62473893
Molecular Formula
C19H12ClN3O2
Formula Weight
349.77
MOL File
1009820-21-6.mol
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CX-4945 Property

Boiling point:
568.5±50.0 °C(Predicted)
Density 
1.490
storage temp. 
Store at -20°C
solubility 
≥103.5 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form 
Orange powder.
pka
2.96±0.30(Predicted)
color 
Yellow to orange
InChI
InChI=1S/C19H12ClN3O2/c20-12-2-1-3-13(9-12)22-18-15-6-7-21-10-16(15)14-5-4-11(19(24)25)8-17(14)23-18/h1-10H,(H,22,23)(H,24,25)
InChIKey
MUOKSQABCJCOPU-UHFFFAOYSA-N
SMILES
C1(NC2=CC=CC(Cl)=C2)C2=C(C=NC=C2)C2=CC=C(C(O)=O)C=C2N=1
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Safety

HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
16779
Product name
CX-4945
Purity
≥98%
Packaging
500μg
Price
$62
Updated
2024/03/01
Cayman Chemical
Product number
16779
Product name
CX-4945
Purity
≥98%
Packaging
1mg
Price
$109
Updated
2024/03/01
Cayman Chemical
Product number
16779
Product name
CX-4945
Purity
≥98%
Packaging
5mg
Price
$206
Updated
2024/03/01
Cayman Chemical
Product number
16779
Product name
CX-4945
Purity
≥98%
Packaging
10mg
Price
$346
Updated
2024/03/01
TRC
Product number
C858600
Product name
CX-4945
Packaging
50mg
Price
$910
Updated
2021/12/16
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CX-4945 Chemical Properties,Usage,Production

Uses

CX-4945 is a protein kinase CK2 inhibitor resulting in cancer cell death and prevention of proliferation. Anti-leukemia agent.

Biological Activity

cx-4945 (silmitasertib) is a potent and selective casein kinase 2 (ck2) inhibitor with ic50 value of 1 nm. it is atp-competitive and can be taken orally [1].cx-4945 has been reported to have antiproliferative activity against a wide range of tumor cell lines. it is suggested that cx-4945 suppresses the ck2 regulated pi3k/akt signaling pathway by inhibiting akt phosphorylation at serine 129, but not by activating pten. additionally, cells treated with cx-4945 had a reduction of p21 phophorylation and an up-regulations of total p21 and p27. cx-4945 has been shown to induce cell-cycle arrest at g2/m phase in breast cancer cell line bt-474. it also causes cell-cycle arrest at g1 phase the breast cancer cell line bxpc-3) [1].in cx-4945 and bxpc-3 derived mouse xenograft model, cx-4945 induced a reduction of phos-p21 expression along with anti-carcinoma effects [1]

in vivo

Silmitasertib (CX-4945) (25 or 75 mg/kg, p.o.) is well tolerated and demonstrated robust antitumor activity with concomitant reductions of the mechanism-based biomarker phospho-p21 (T145) in murine xenograft models[1].

IC 50

CK2α: 1 nM (IC50); CK2α': 1 nM (IC50)

References

[1] siddiqui-jain a1, drygin d, streiner n, chua p, pierre f, o'brien se, bliesath j, omori m, huser n, ho c, proffitt c, schwaebe mk, ryckman dm, rice wg,anderes k. cx-4945, an orally bioavailable selective inhibitor of protein kinase ck2, inhibits prosurvival and angiogenic signaling and exhibits antitumor efficacy. cancer res. 2010 dec 15; 70 (24): 10288-98.

CX-4945 Preparation Products And Raw materials

Raw materials

Preparation Products

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CX-4945 Suppliers

China 175 India 2 United Kingdom 1 United States 19 Global 197
Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
Fax
001-617-206-9595
Email
sales@chemreagents.com
Country
United States
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10186
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MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
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58
AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Fax
+1 (866) 333-9607
Email
info@adooq.com
Country
United States
ProdList
2782
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58
Target molecule Corp.
Tel
857-239-0968
Fax
857-239-8801
Email
service1@targetmol.com
Country
United States
ProdList
2559
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60
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4660
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TargetMol Chemicals Inc.
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+1-781-999-5354; +17819995354
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marketing@targetmol.com
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United States
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58
InvivoChem
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+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
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6391
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Cckinase, Inc.
Tel
+1 (732)236-3202
Email
sales@cckinase.com
Country
United States
ProdList
2738
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58
BOC Sciences
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+1-631-485-4226
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1-631-614-7828
Email
inquiry@bocsci.com
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United States
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Alchem Pharmtech,Inc.
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8485655694
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sales@alchempharmtech.com
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United States
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Aladdin Scientific
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Email
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United States
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ApexBio Technology
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Cayman Chemical Company
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cayman@caymanchem.com
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United States Biological
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Creative Enzymes
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Frontier Scientific, Inc.
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Matrix Scientific
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Santa Cruz Biotechnology, Inc.
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scbt@scbt.com
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View Lastest Price from CX-4945 manufacturers

Career Henan Chemical Co
Product
5-((3-Chlorophenyl)amino)benzo[c][2,6]naphthyridine-8-carboxylic acid 1009820-21-6
Price
US $1.00/KG
Min. Order
1KG
Purity
Min98% HPLC
Supply Ability
g/kg/ton
Release date
2019-12-23

1009820-21-6, CX-4945Related Search:

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  • 5-[(3-chlorophenyl)amino]-Benzo[c]-2,6-naphthyridine-8-carboxylic acid
  • CX-4945
  • Silmitasertib
  • CX-4945 Silmitasertib
  • CX-4945, CX4945
  • Silmitasertib(CX-4945)
  • 5-[(3-Chlorophenyl)amino]benzo[c]-2,6-naphthyridine-8-carboxylic acid CX-4945 (Silmitasertib)
  • CX-4945, >=98%
  • CX-4945 (SILMITASERTIB);CX 4945; CX4945
  • Silmitasertib, 98%, a potent and selective ATP-competitive CK2 inhibitor
  • CX4945 CX-4945; CX 4945; SILMITASERTIB.
  • CS-1985
  • SILMITASERTIB; CX 4945; CX4945
  • mitasertib (CX-4945)
  • Benzo[c]-2,6-naphthyridine-8-carboxylic acid, 5-[(3-chlorophenyl)amino]-
  • 4-di-tert-butylphenyl)phosphate
  • CX-4945 5-[(3-chlorophenyl)amino]-Benzo[c]-2,6-naphthyridine-8-carboxylic
  • CX-4945 Silmitasertib CX4945
  • SPIROBIINDANE CX-4945
  • Silmitasertib, 10 mM in DMSO
  • Silmitasertib (CX-4945) ，S2248
  • 1009820-21-6
  • Inhibitors