6-Iodo-1H-quinolin-2-one
- Product Name
- 6-Iodo-1H-quinolin-2-one
- CAS No.
- 99455-01-3
- Chemical Name
- 6-Iodo-1H-quinolin-2-one
- Synonyms
- 6-Iodoquinolin-2-o;6-Iodoquinolin-2-ol;6-Iodo-2(1H)- quinolone;6-iodo-2(1H)-Quinolinone;6-Iodo-1H-quinolin-2-one;2(1H)-Quinolinone, 6-iodo-
- CBNumber
- CB62484767
- Molecular Formula
- C9H6INO
- Formula Weight
- 271.05
- MOL File
- 99455-01-3.mol
6-Iodo-1H-quinolin-2-one Property
- Melting point:
- 260-263 °C
- Boiling point:
- 413.1±45.0 °C(Predicted)
- Density
- 1.880
- storage temp.
- 2-8°C(protect from light)
- pka
- 10.92±0.70(Predicted)
- Appearance
- Yellow to brown Solid
Safety
- HS Code
- 2933499090
N-Bromosuccinimide Price
- Product number
- W9873
- Product name
- 6-Iodoquinolin-2-ol
- Packaging
- 250mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- 146508
- Product name
- 6-Iodo-1H-quinolin-2-one
- Purity
- 95%
- Packaging
- 1g
- Price
- $225
- Updated
- 2021/12/16
- Product number
- HCH0368143
- Product name
- 6-IODOQUINOLIN-2-OL
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $484.05
- Updated
- 2021/12/16
- Product number
- 4H56-H-61
- Product name
- 6-Iodoquinolin-2(1H)-one
- Packaging
- 1g
- Price
- $661
- Updated
- 2021/12/16
- Product number
- 146508
- Product name
- 6-Iodo-1H-quinolin-2-one
- Purity
- 95%
- Packaging
- 5g
- Price
- $665
- Updated
- 2021/12/16
6-Iodo-1H-quinolin-2-one Chemical Properties,Usage,Production
Synthesis
99465-20-0
99455-01-3
(2E)-3-(ethoxy)-N-(4-iodophenyl)-2-acrylamide (33 g, 104 mmol) was added batchwise to stirred concentrated sulfuric acid (300 mL) at 0 °C. The reaction mixture was stirred continuously for 2 hours at room temperature. Subsequently, the reaction mixture was quenched by slowly pouring it into about 1 kg of ice. The resulting solid product was collected by filtration and washed sequentially with water (3 times) and acetonitrile (2 times). Finally, the solid was dried under vacuum to afford 6-iodo-2-hydroxyquinoline as an off-white solid (27.1 g, yield: 96%). The structure of the product was confirmed by 1H NMR (400 MHz, chloroform-d) and ES-LCMS: 1H NMR δ= 6.73 (d, J = 9.6Hz, 1H), 7.17 (d, J = 8.8Hz, 1H), 7.74 (d, J = 9.6Hz, 1H), 7.77 (dd, J = 8.8,1.4Hz, 1H), 7.93 ( d, J = 1.4 Hz, 1H); ES-LCMS: m/z 272 (M + 1).
References
[1] Patent: WO2012/37108, 2012, A1. Location in patent: Page/Page column 134
[2] Patent: US2006/63804, 2006, A1. Location in patent: Page/Page column 9
[3] Journal of Medicinal Chemistry, 1988, vol. 31, # 10, p. 2048 - 2056
[4] Patent: US4728654, 1988, A
6-Iodo-1H-quinolin-2-one Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-Iodo-1H-quinolin-2-one manufacturers
- Product
- 6-Iodo-1H-quinolin-2-one 99455-01-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2019-07-05