Anacetrapib

Product Name: Anacetrapib
CAS No.: 875446-37-0
Chemical Name: Anacetrapib
Synonyms: CS-66;Mk0859;Mk-0859;Anacetrapib;Anacetripib;Timapiprant;Unii-p7T269pr6s;Anacetrapib 13C6;Anacetrapib, >=99%;Anacetrapib(MK0859)
CBNumber: CB62487713
Molecular Formula: C30H25F10NO3
Formula Weight: 637.51
MOL File: 875446-37-0.mol

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Anacetrapib Property

Boiling point:: 555.3±50.0 °C(Predicted)
Density: 1.345
storage temp.: Store at -20°C
solubility: ≥31.9 mg/mL in DMSO; insoluble in H2O; ≥86.6 mg/mL in EtOH
form: solid
pka: -2.30±0.60(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 21558
Product name: Anacetrapib
Purity: ≥98%
Packaging: 1mg
Price: $68
Updated: 2024/03/01

Cayman Chemical

Product number: 21558
Product name: Anacetrapib
Purity: ≥98%
Packaging: 5mg
Price: $268
Updated: 2024/03/01

Cayman Chemical

Product number: 21558
Product name: Anacetrapib
Purity: ≥98%
Packaging: 10mg
Price: $435
Updated: 2024/03/01

Cayman Chemical

Product number: 21558
Product name: Anacetrapib
Purity: ≥98%
Packaging: 25mg
Price: $1002
Updated: 2024/03/01

TRC

Product number: A637200
Product name: Anacetrapib
Packaging: 25mg
Price: $6720
Updated: 2021/12/16

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Anacetrapib Chemical Properties,Usage,Production

Uses

An orally active and potent cholesterol ester transfer protein (CETP) inhibitor for the treatment of atherosclerosis, in particular dyslipidemia.

Biological Activity

anacetrapib, also known as mk-0859, is a potent and selective inhibitor of cholesteryl ester transfer protein (cetp) that exhibits strong inhibition against cetp-mediated transfer of cholesteryl esters and triglycerides with values of inhibition constant ic50 of 16 nm and 29 nm respectively. anacetrapib is mainly metabolized by cyp3a4 through o-demethylation, hydroxylation on the biphenyl moiety and hydroxylation on the isopropyl side chain resulting in three oxidative metabolites m1, m2 and m3 respectively. anacetrapib is being investigated for the treatment of primary hypercholesterolemia and mixed hyperlipidemia due to its impressive effects to lower low-density lipoprotein (ldl) cholesterol levels and increase high-density lipoprotein (hdl) cholesterol levels without any associated major adverse events.tan ey, hartmann g, chen q, pereira a, bradley s, doss g, zhang as, ho jz, braun mp, dean dc, tang w, kumar s. pharmacokinetics, metabolism, and excretion of anacetrapib, a novel inhibitor of the cholesteryl ester transfer protein, in rats and rhesus monkeys. drug metab dispos. 2010;38(3):459-473.kumar s, tan ey, hartmann g, biddle z, bergman aj, dru j, ho jz, jones an, staskiewicz sj, braun mp, karanam b, dean dc, gendrano in, graves mw, wagner ja, krishna r. metabolism and excretion of anacetrapib, a novel inhibitor of the cholesteryl ester transfer protein, in humans. drug metab dispos. 2010;38(3):474-483

Enzyme inhibitor

This cholesteryl ester transfer protein (or CETP) inhibitor (FW = 637.51 g/mol; CAS 875446-37-0), also known by the code name MK-0859, reduces plasma cholesterol concentrations, thereby increasing serum highdensity lipoprotein levels and preventing cardiovascular disease associated with hypercholesteremia. X-ray crystal studies suggest that CETP is a crescent-shaped protein with a 6-nm hydrophobic tunnel traversing its core Both of the tunnel’s two entrances face the protein’s concave surface, which most likely is the interaction platform for binding HDL particles and engaging its lipoprotein constituents. CETP mediates the reciprocal transfer of neutral lipids (e.g., cholesteryl esters and triglycerides) and phospholipids between different lipoprotein fractions in blood plasma. Anacetrapib is unlike many CETP inhibitors, which increase systolic blood pressure. Anacetrapib also exhibits a low-to-moderate degree of absorption after oral dosing and majority of the absorbed dose is eliminated via oxidation to a series of hydroxylated metabolites that undergo conjugation with glucuronate before excretion into bile. Unlike torcetrapib, another CETP inhibitor, anacetrapib does not elevate blood pressure, alter electrolytes, or cause any significant side effects.

target

rhCETP

Anacetrapib Preparation Products And Raw materials

Raw materials

Preparation Products

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Anacetrapib Suppliers

Canada 2 China 168 India 2 United Kingdom 2 United States 16 Global 190

LGM Pharma

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ApexBio Technology LLC

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Target molecule Corp.

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Musechem

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TargetMol Chemicals Inc.

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InvivoChem

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Cckinase, Inc.

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BOC Sciences

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Aladdin Scientific

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ApexBio Technology

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View Lastest Price from Anacetrapib manufacturers

Hebei Weibang Biotechnology Co., Ltd

Product: Anacetrapib 875446-37-0
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-11-05

Shaanxi Dideu Medichem Co. Ltd

Product: Anacetrapib 875446-37-0
Price: US $0.00-0.00/KG
Min. Order: 1g
Purity: 99%
Supply Ability: 2000tons
Release date: 2019-12-31

Hebei Yanxi Chemical Co., Ltd.

Product: Anacetrapib 875446-37-0
Price: US $50.00-25.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 5 tons
Release date: 2023-10-25

875446-37-0, AnacetrapibRelated Search:

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(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-({2-[4-fluoro-2-methoxy-5-(propan-2-yl)phenyl]-5-(trifluoromethyl)phenyl}methyl)-4-methyl-1,3-oxazolidin-2-one

Anacetrapib

Mk0859

Mk-0859

Unii-p7T269pr6s

(4S,5R)-5-[3,5-Bis(trifluoromethyl)phenyl]-3-[[4'-fluoro-5'-isopropyl-2'-methoxy-4-(trifluoromethyl)biphenyl-2-yl]methyl]-4-methyl-1,3-oxazolidin-2-one

Anacetrapib(MK0859)

2-Oxazolidinone, 5-[3,5-bis(trifluoroMethyl)phenyl]-3-[[4'-fluoro-2'-Methoxy-5'-(1-Methylethyl)-4-(trifluoroMethyl)[1,1'-biphenyl]-2-yl]Methyl]-4-Methyl-, (4S,5R)-

(4S,5R)-5-[3,5-Bis(trifluoroMethyl)phenyl]-3-[[4'-fluoro-2'-Methoxy-5'-(1-Methylethyl)-4-(trifluoroMethyl)[1,1'-biphenyl]-2-yl]Methyl]-4-Methyl-2-oxazolidinone

(4S,5R)-5-[3,5-Bis(trifluoroMethyl)phenyl]-3-[[4'-fluoro-5'-isopropyl-2'-Methoxy-4

(4S,5R)-5-(3,5-bis(trifluoroMethyl)phenyl)-3-((4'-fluoro-2'-Methoxy-4-(trifluoroMethyl)-[1,1'-biphenyl]-2-yl)Methyl)-4-Methyloxazolidin-2-one

(4S,5R)-5-(3,5-bis(trifluoroMethyl)phenyl)-3-((4-fluoro-5-isopropyl-2-Methoxy-4-(trifluoroMethyl)-[1,1-biphenyl]-2-

MK0859; MK-0859; MK 0859; ANACETRAPIB

CS-66

MK-0859; MK 0859; MK0859

Anacetripib

(4S,5R)-5-[3,5-Bis(trifluoromethyl)phenyl]-3-[[4'-fluoro-5'-isopropyl-2'-methoxy-4-(trifluoromethyl)biphenyl-2-yl]methyl]-4-methyl-1,3-oxazolidin-2-one Anacetrapib (MK-0859)

(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-{[4'-fluoro-2'-methoxy-5'-(propan-2-yl)-4-(trifluoromethyl)biphenyl-2-yl]methyl}-4-methyl-1,3-oxazolidin-2-one

EZSolution Anacetrapib

Anacetrapib, >=99%

Timapiprant

(4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-3-((4'-fluoro-5'-isopropyl-2'-methoxy-4-(trifluoromethyl)-[1,1'-biphenyl]-2-yl)methyl)-4-methyloxazolidin-2-one

(4S,5R)-5-[3,5-Bis(trifluoromethyl)phenyl]-3-({2-[4-fluoro-2-methoxy-5-(propan-2-yl)phenyl]-5-

Anacetrapib USP/EP/BP

(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-{[4'-fluoro-2'-...

Anacetrapib 13C6

TIANFUCHEM-- Anacetrapib

(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-[[2-(4-fluoro-5-isopropyl-2-methoxy-phenyl)-5-(trifluoromethyl)phenyl]methyl]-4-methyl-oxazolidin-2-one

(4S,5R)-5-(3,5-Bis(trifluoromethyl)phenyl)-3-((4'-fluoro-5'-isopropyl-2'-methoxy-4-(trifluoromethyl)-[1,1'-biphenyl]-2-yl)methyl)-4-methyloxazolidin-2-one

875446-37-0

C30H25F10NO3

Inhibitor

CETP inhibitor

Aromatics

Chiral Reagents

Heterocycles

Inhibitors

Intermediates & Fine Chemicals

Pharmaceuticals

Anacetrapib