Choline Fenofibrate

ChemicalBook > CAS DataBase List > Choline Fenofibrate

Product Name: Choline Fenofibrate
CAS No.: 856676-23-8
Chemical Name: Choline Fenofibrate
Synonyms: Choline Fenofibrate;Trilipix;Abt 335;Unii-4bmh7izt98;Fenofibrate de choline;Unii-4bmh7izt98 USP/EP/BP;Unii-4bmh7izt98 856676-23-8;Choline Fenofibrate (CFRC-3);Fenofibric acid choline salt;Choline fenofibrate (ABT-335)
CBNumber: CB62494614
Molecular Formula: C22H28ClNO5
Formula Weight: 421.91442
MOL File: 856676-23-8.mol

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Choline Fenofibrate Property

Melting point:: 210-212°C
storage temp.: Hygroscopic, -20°C Freezer, Under Inert Atmosphere
solubility: Methanol (Slightly), Water (Slightly)
form: Solid
color: White to Off-White
Stability:: Hygroscopic
InChI: InChI=1S/C17H15ClO4.C5H14NO/c1-17(2,16(20)21)22-14-9-5-12(6-10-14)15(19)11-3-7-13(18)8-4-11;1-6(2,3)4-5-7/h3-10H,1-2H3,(H,20,21);7H,4-5H2,1-3H3/q;+1/p-1
InChIKey: JWAZHODZSADEHB-UHFFFAOYSA-M
SMILES: OCC[N+](C)(C)C.CC(C(=O)[O-])(OC1C=CC(C(=O)C2C=CC(Cl)=CC=2)=CC=1)C

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Safety

HS Code: 2923100000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ApexBio Technology

Product number: A3308
Product name: CholineFenofibrate
Packaging: 200mg
Price: $41
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC20421
Product name: Choline fenofibrate
Packaging: 500mg
Price: $70
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC20421
Product name: Choline fenofibrate
Packaging: 1g
Price: $100
Updated: 2021/12/16

ChemScene

Product number: CS-0893
Product name: CholineFenofibrate
Purity: 99.93%
Packaging: 10mg
Price: $120
Updated: 2021/12/16

AK Scientific

Product number: 3320AC
Product name: Cholinefenofibrate(ABT-335)
Packaging: 10mg
Price: $120
Updated: 2021/12/16

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Choline Fenofibrate Chemical Properties,Usage,Production

Description

Choline fenofibrate, a salt formulation of fenofibric acid, is a lipid regulating agent available as delayed release capsules for oral administration. It is indicated in combination with a statin to reduce TG and increase high-density lipoprotein cholesterol (HDL-C) in patients with mixed dyslipidemia and coronary heart disease (CHD) or a CHD-risk equivalent who are optimal for statin therapy to achieve their lowdensity lipoprotein cholesterol (LDL-C) goal. In addition, choline fenofibrate is indicated as monotherapy in patients with severe hypertriglyceridemia to reduce TG, and in patients with primary hyperlipidemia or mixed dyslipidemia to reduce elevated LDL-C, total cholesterol, TG, apolipoprotein B, and to increase HDL-C. Fenofibric acid is also the active metabolite of fenofibrate (Tricor), which has been previously marketed for the treatment of hypercholesterolemia and hypertriglyceridemia. The primary mode of action of fenofibric acid is through the activation of the nuclear transcription factor PPARa, predominantly expressed in tissues that metabolize fatty acids, such as the liver, kidney, heart, and muscle.
On activation by binding of the fibrate, PPARa binds as heterodimers with retinoid X receptor (RXR), which subsequently recognizes and binds to specific PPARa-response elements leading to modulation of expression of the target genes. In particular, the activity of lipoprotein lipase is increased and synthesis of apoprotein C-III is decreased, which together enhance the clearance of circulating TG-rich lipoproteins. The resulting fall in TG produces an alteration in the size and composition of LDL from small dense particles to large buoyant particles. These larger particles have a greater affinity for cholesterol receptors and are catabolized rapidly. Choline fenofibriate acid is contraindicated in patients with severe renal impairment.

Chemical Properties

White Solid

Originator

Abbott (United States)

Uses

A new formulation of fenofibric acid, ABT-335, co-administered with statins.

brand name

TriLipix

Side effects

The most common adverse reactions observed with the use of fenofibric acid alone or in combination with a statin are headache, back pain, nasopharyngitis, nausea, myalgia, diarrhea, and upper respiratory tract infection.

Synthesis

Choline To Market, To Market 2008 enofibrate is chemically derived from p-anisole in four steps through Friedel Crafts acylation with p-chlorobenzoyl chloride to the corresponding benzophenone derivative, followed by methyl ether cleavage with hydrogen bromide, alkylation of the phenolic hydroxyl group with 2-bromo-2-methylpropanoic acid using sodium hydroxide, and finally salt formation with choline.

Choline Fenofibrate Preparation Products And Raw materials

Raw materials

Preparation Products

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Choline Fenofibrate Suppliers

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View Lastest Price from Choline Fenofibrate manufacturers

Dideu Industries Group Limited

Product: Unii-4bmh7izt98 856676-23-8
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons min
Release date: 2021-08-16

856676-23-8, Choline FenofibrateRelated Search:

5-Aminosalicylic acid FENOFIBRATE RELATED COMPOUND C (25 MG) (1-METHYLETHYL 2-[[2-[4-(4-CHLOROBENZOYL)PHENOXY]-2-METHYLPROPANOYL]OXY]-2-METHYLPROPANOATE) Poly(vinyl alcohol) Doxercalciferol Gabapentin Etamsylate Vildagliptin Oxybutynin Parecoxib Entacapone Dutasteride tadalafi Esomeprazole Ibrutinib Pregabalin Ciclesonide Simvastatin Cetirizine

Abt 335

Fenofibrate de choline

Trilipix

Unii-4bmh7izt98

Choline Fenofibrate

2-Hydroxy-N,N,N-triMethylethanaMiniuM 2-[4-(4-chlorobenzoyl)phenoxy] -2-Methylpropanoate

2-hydroxy-N,N,N-trimethyl, 2-{4-(4-chlorobenzoyl)phenoxy]-2-methylpropanoate

Fenofibrate Impurity 8(Choline Fenofibrate)

2-Hydroxy-N,N,N-trimethylethan-1-aminium 2-(4-(4-chlorobenzoyl)phenoxy)-2-methylpropanoate

2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropanoate,2-hydroxyethyl(trimethyl)azanium

Choline Fenofibrate (CFRC-3)

Fenofibric acid choline salt

Unii-4bmh7izt98 USP/EP/BP

Fenofibric acid choline saltQ: What is Fenofibric acid choline salt Q: What is the CAS Number of Fenofibric acid choline salt Q: What is the storage condition of Fenofibric acid choline salt Q: What are the applications of Fenofibric acid choline salt

Unii-4bmh7izt98 856676-23-8

tert-butylN-(1-amino-2-oxoazetidin-7-yl)carbamate

Choline fenofibrate (ABT-335)

856676-23-8

C22H28ClNO5

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