3-NITRO-4-QUINOLINOL

Product Name: 3-NITRO-4-QUINOLINOL
CAS No.: 50332-66-6
Chemical Name: 3-NITRO-4-QUINOLINOL
Synonyms: 3-nitro-4-quinolone;3-Nitro-4-Quinolino;3-NITRO-4-QUINOLINOL;3-NITROQUINOLIN-4-OL;Imiquimod Impurity 12;Imiquimod impurity 15;4-QUINOLINOL, 3-NITRO-;3-Nitro-4-quinolinol>Racecadotril Impurity 17;3-nitro-1H-quinolin-4-one
CBNumber: CB6251259
Molecular Formula: C9H6N2O3
Formula Weight: 190.16
MOL File: 50332-66-6.mol

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3-NITRO-4-QUINOLINOL Property

Melting point:: >3000C
Boiling point:: 334.7±22.0 °C(Predicted)
Density: 1.496±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
solubility: DMF (Slightly), DMSO (Slightly)
form: Solid
pka: -0.02±0.50(Predicted)
color: Light Beige
Stability:: <-200C
InChI: InChI=1S/C9H6N2O3/c12-9-6-3-1-2-4-7(6)10-5-8(9)11(13)14/h1-5H,(H,10,12)
InChIKey: ZWISCKSGNCMAQO-UHFFFAOYSA-N
SMILES: N1C2C(=CC=CC=2)C(O)=C([N+]([O-])=O)C=1
CAS DataBase Reference: 50332-66-6(CAS DataBase Reference)

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Safety

Risk Statements: 25-37-38-41
Safety Statements: 26-36/37/39
RIDADR: 2811
HazardClass: IRRITANT
HS Code: 29334900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TCI Chemical

Product number: N0992
Product name: 3-Nitro-4-quinolinol
Purity: >98.0%(GC)(T)
Packaging: 200mg
Price: $105
Updated: 2025/07/31

TCI Chemical

Product number: N0992
Product name: 3-Nitro-4-quinolinol
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $352
Updated: 2025/07/31

TRC

Product number: N496210
Product name: 3-Nitro-4-hydroxyquinoline
Packaging: 10g
Price: $50
Updated: 2021/12/16

TRC

Product number: N496210
Product name: 3-Nitro-4-hydroxyquinoline
Packaging: 25g
Price: $100
Updated: 2021/12/16

AK Scientific

Product number: W6565
Product name: 3-Nitroquinolin-4-ol
Packaging: 25g
Price: $161
Updated: 2021/12/16

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3-NITRO-4-QUINOLINOL Chemical Properties,Usage,Production

Chemical Properties

Tan Solid

Uses

3-Nitro-4-hydroxyquinoline (cas# 50332-66-6) is a compound useful in organic synthesis.

Definition

ChEBI: 3-nitro-1H-quinolin-4-one is a nitro compound and a member of quinolines.

Synthesis Reference(s)

Journal of the American Chemical Society, 69, p. 365, 1947 DOI: 10.1021/ja01194a060

Synthesis

611-36-9

50332-66-6

Step 1: 5 g of 4-hydroxyquinoline (34.48 mmol, purchased from Jiuding Chemical) was dissolved in 40 mL of propionic acid (purity ≥99.5%) and heated to 120 °C. Subsequently, 3.5 mL of concentrated nitric acid (41.38 mmol, concentration 65-68%) was diluted with propionic acid and slowly added dropwise to the reaction system over 1.5 hours. After about 15 minutes of dropwise addition, a yellow precipitate appeared in the reaction solution. 20 mL of propionic acid was added and the reaction was continued at reflux for 1 hour. The progress of the reaction was monitored by thin layer chromatography (TLC) to confirm that the 4-hydroxyquinoline was completely consumed. The heating was stopped and the reaction solution was cooled to room temperature. The reaction mixture was filtered, the filter cake was washed with petroleum ether and dried under vacuum to give 4-hydroxy-3-nitroquinoline as a yellow solid (5.28 g, 80.7% yield).

References

[1] Patent: US5367076, 1994, A
[2] Patent: US5175296, 1992, A
[3] Journal of Medicinal Chemistry, 2005, vol. 48, # 10, p. 3481 - 3491
[4] Patent: CN108003153, 2018, A. Location in patent: Paragraph 0063; 0068
[5] Patent: US2011/136801, 2011, A1. Location in patent: Page/Page column 21

3-NITRO-4-QUINOLINOL Preparation Products And Raw materials

Raw materials

Ethanol 4-Hydroxyquinoline Propionic acid Nitric acid

Preparation Products

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3-NITRO-4-QUINOLINOL Suppliers

Americas 1 Canada 1 China 145 Europe 3 Germany 2 India 3 Japan 1 Switzerland 1 The Netherlands 1 Ukraine 1 United Kingdom 6 United States 24 Global 189

Synchem OHG

Tel: +49 5662 408730
Fax: +49 5662 4087320
Email: info@synchem.de
Country: Germany
ProdList: 4705
Advantage: 70

Service Chemical Inc.

Tel: --
Fax: --
Email: sales@chemos-group.com
Country: Germany
ProdList: 6350
Advantage: 71

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View Lastest Price from 3-NITRO-4-QUINOLINOL manufacturers

Career Henan Chemical Co

Product: 3-NITRO-4-QUINOLINOL 50332-66-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2019-07-03

50332-66-6, 3-NITRO-4-QUINOLINOLRelated Search:

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4-QUINOLINOL, 3-NITRO-

4-HYDROXY-3-NITROQUINOLINE

3-NITRO-4-QUINOLINOL

3-NITRO-4-HYDROXYQUINOLINE

3-NITROQUINOLIN-4-OL

3-Nitro-4-Hydroxy quinolin

4-Hydroxy-3-nitroquinoline 98%

3-nitro-1,4-dihydroquinolin-4-one

3-Nitro-4-hydroxyquinoline ,97%

4(1H)-quinolinone, 3-nitro-

3-nitro-1H-quinolin-4-one

3-nitro-4-quinolone

3-Nitro-4-quinolinol&gt

3-NITRO-4-QUINOLINOL ISO 9001：2015 REACH

Imiquimod Impurity 12

4-Hydroxy-3-nitroquinoline/3-Nitroquinolin-4-ol

Racecadotril Impurity 17

Imiquimod impurity 15

3-Nitro-4-Quinolino

50332-66-6

Heterocyclic Compounds

pharmacetical

Heterocycles

50332-66-6