3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one

Description References

Product Name: 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one
CAS No.: 503615-03-0
Chemical Name: 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one
Synonyms: 5,6-Dihydro-3-(4-morpholinyl)-1-(4-nitrophenyl)-2(1H)-pyridinone;TECO-011;Apixaban int3;PR-204 impurity;Apixaban Impurity 19;Apixaban Intermediate3;Apixaban related impurities 1;2-Naphthalenecarboxylicacid,12-amino-,methylester;5-morpholino-1-(4-nitrophenyl)-2,3-dihydropyridin-6-one;Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one
CBNumber: CB62516219
Molecular Formula: C15H17N3O4
Formula Weight: 303.31
MOL File: 503615-03-0.mol

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3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one Property

Boiling point:: 506.5±50.0 °C(Predicted)
Density: 1.356
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: Chloroform (Slightly), Methanol (Slightly, Heated)
form: Solid
pka: 3.11±0.20(Predicted)
color: Light Yellow
InChI: InChI=1S/C15H17N3O4/c19-15-14(16-8-10-22-11-9-16)2-1-7-17(15)12-3-5-13(6-4-12)18(20)21/h2-6H,1,7-11H2
InChIKey: LBFAEOWNWSDWRZ-UHFFFAOYSA-N
SMILES: C1(=O)N(C2=CC=C([N+]([O-])=O)C=C2)CCC=C1N1CCOCC1

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: M725125
Product name: 3-(Morpholinyl)-N-(4-nitrophenyl)-5,6-dihydropyridin-2-one
Packaging: 5g
Price: $745
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0389374
Product name: 3-MORPHOLINO-1-(4-NITROPHENYL)-5,6-DIHYDROPYRIDIN-2(1H)-ONE
Purity: 95.00%
Packaging: 5MG
Price: $497.13
Updated: 2021/12/16

ChemScene

Product number: CS-M1442
Product name: 3-morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one
Purity: 99.68%
Packaging: 100g
Price: $780
Updated: 2021/12/16

ChemScene

Product number: CS-M1442
Product name: 3-morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one
Purity: 99.68%
Packaging: 5g
Price: $75
Updated: 2021/12/16

ChemScene

Product number: CS-M1442
Product name: 3-morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one
Purity: 99.68%
Packaging: 10g
Price: $125
Updated: 2021/12/16

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3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one Chemical Properties,Usage,Production

Description

3-(4-Morpholinyl)-1-(4-nitrophenyl)-5, 6-dihydro-2(1H)-pyridinone is the intermediate for the synthesis of apixaban, which is an anticoagulant for the treatment of venous thromboembolic events.

References

Chao, H. E., et al. "Synthesis of Apixaban." Chinese Journal of Pharmaceuticals (2014).
https://en.wikipedia.org/wiki/Apixaban

Uses

3-(Morpholinyl)-N-(4-nitrophenyl)-5,6-dihydropyridin-2-one is a reagent in the synthesis of 4,5-dehydro Apixaban (D229385) an impurity of Apixaban (A726700), a potent, direct, selective, and orally active inhibitor of coagulation factor Xa. It is a potential new oral coagulant that may be useful prevention of venous thromboembolism in total hip, knee replacement orthopedic surgery and stroke in treatment of patient with venous thromboembolic disorder or with atrial fibrillation

3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one Preparation Products And Raw materials

Raw materials

Preparation Products

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3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one Suppliers

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View Lastest Price from 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one manufacturers

Jinan Million Pharmaceutical Co., Ltd

Product: 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one 503615-03-0
Price: US $2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1200KG/M
Release date: 2023-08-15

Speranza Chemical Co., Ltd.

Product: 3-(4-Morpholinyl)-1-(4-nitrophenyl)-5,6-dihydro-2(1H)-pyridinone 503615-03-0
Price: US $25.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 20 tons
Release date: 2019-12-24

Suzhou Nordica Biopharma CO.,LTD

Product: 5,6-Dihydro-3-(4-morpholinyl)-1-(4-nitrophenyl)-2(1H)-pyridinone 503615-03-0
Price: US $0.00-0.00/kg
Min. Order: 0.1kg
Purity: 0.99
Supply Ability: 1 tons
Release date: 2024-11-15

503615-03-0, 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-oneRelated Search:

ethyl 6-(4-aMinophenyl)-1-(4-Methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate 5-chloro-N-(4-(5-morpholino-6-oxo-3,6-dihydropyridin-1(2H)-yl)phenyl)pentanamide Acetic acid, 2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene], ethyl ester 3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one 1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone 1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester 1-(4-Nitrophenyl)-2-piperidinone 4,5,6,7-Tetrahydro-1-(4-methoxyphenyl)-6-[4-(5-methyl-2-oxo-1-piperidinyl)phenyl]-7-oxo-1H-pyrazolo[3,4-c]pyridine-3-carboxamide 1-(4-Methoxyphenyl)-6-(4-(2-Methyl-6-oxopiperidin-1-yl)phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxaMide Apixaban IMpurity 6 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid Apixaban Impurity 12 Apixaban 1-(4-chlorophenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxaMide 1-(4-Methoxyphenyl)-6-(4-iodophenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester Apixaban IMpurity 3 Apixaban Impurity 17 Apixaban IMpurity 4 (BMS-728626-01)

3-(4-Morpholinyl)-1-(4-nitrophenyl)-5,6-dihydro-2(1H)-pyridinone

5,6-Dihydro-3-(4-morpholinyl)-1-(4-nitrophenyl)-2(1H)-pyridinone

Apixaban Intermediate3

5-morpholin-4-yl-1-(4-nitrophenyl)-2,3-dihydropyridin-6-one

3-(Morpholin-4-yl)-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one (Nitro MPDP)

3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one

Apixaban Impurity 19

5-morpholino-1-(4-nitrophenyl)-2,3-dihydropyridin-6-one

5,6 - dihydro-3 - (4 - morpholin-yl) -1 - (4 - nitrophenyl) -2 (1H) - pyridone

3-(Morpholinyl)-N-(4-nitrophenyl)-5,6-dihydropyridin-2-one

Apixaban int3

Apixaban related impurities 1

2(1H)-Pyridinone, 5,6-dihydro-3-(4-morpholinyl)-1-(4-nitrophenyl)-

Apixaban intermediates，5,6-Dihydro-3-(4-morpholinyl)-1-(4- nitrophenyl)-2(1H)-pyridinone

5,6-Dihydro-3-(4-morpholinyl)-1-(4-nitrophenyl)-2(1H)-pyridi...

Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one

2-Naphthalenecarboxylicacid,12-amino-,methylester

TECO-011

5,6-Dihydro-3-morpholino-1-(4-nitrophenyl) pyridine-2(1H)-one

1-(4-Nitrophenyl)- 3-Morpholin- 4-yl-5,6- dihydopyridin- 2(1H)-one

PR-204 impurity

3-(morpholin-4-yl)-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one

503615-03-0