BIIB-021

Product Name: BIIB-021
CAS No.: 848695-25-0
Chemical Name: BIIB-021
Synonyms: CS-479;CNF2024;BIIB-021;CNF-2024EC102;BIIB021/CNF2024;BIIB 021, ≥98%;BIIB021 BIIB-021;BIIB-021 USP/EP/BP;CNF 2024 - BIIB 021;BIIB021(CNF2024)BIIB021
CBNumber: CB62516264
Molecular Formula: C14H15ClN6O
Formula Weight: 318.76
MOL File: 848695-25-0.mol

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BIIB-021 Property

Melting point:: 192-193℃
Boiling point:: 588.5±60.0 °C(Predicted)
Density: 1.50
storage temp.: -20°C
solubility: Soluble in DMSO (>25 mg/ml)
pka: 6.07±0.40(Predicted)
form: solid
color: White
Stability:: Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 montha.

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Safety

HS Code: 2921490090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 18269
Product name: BIIB021
Purity: ≥98%
Packaging: 1mg
Price: $25
Updated: 2024/03/01

Cayman Chemical

Product number: 18269
Product name: BIIB021
Purity: ≥98%
Packaging: 5mg
Price: $50
Updated: 2024/03/01

Cayman Chemical

Product number: 18269
Product name: BIIB021
Purity: ≥98%
Packaging: 10mg
Price: $88
Updated: 2024/03/01

Cayman Chemical

Product number: 18269
Product name: BIIB021
Purity: ≥98%
Packaging: 25mg
Price: $156
Updated: 2024/03/01

Tocris

Product number: 4608
Product name: BIIB021
Purity: ≥98%(HPLC)
Packaging: 10
Price: $219
Updated: 2021/12/16

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BIIB-021 Chemical Properties,Usage,Production

Description

BIIB021 is a potent HSP90 inhibitor (IC50 = 30 nM HER-2 degradation).1 It inhibited the proliferation of MCF7 and BT474 breast cancer cell lines (IC50 = 100 nM for each).? BIIB021 has shown efficacy as a therapeutic in multiple cancer models.2-5

Uses

BIIB 021 an orally available, fully synthetic small-molecule inhibitor of the heat shock protein Hsp90. Studies show that BIIB 021 adminisitration led to degradation of Hsp90 client proteins measured in tumor tissue and resulted in the inhibition of tumor growth in several human tumor xenograft models.

Definition

ChEBI: A member of the class of 2-aminopurines that is 2-aminopurine which is substituted by a chlorine at position 6 and by a (4-methoxy-3,5-dimethylpyridin-2-yl)methyl group at position 9.

References

Kasibhatla et al. (2007), Rationally designed high-affinity 2-amino-6-halopurine heat shock protein 90 inhibitors that exhibit potent antitumor activity; J. Med. Chem. 50 2767 Lundgren et al. (2009), BIIB021, an orally available, fully synthetic small-molecule inhibitor of the heat shock protein Hsp90; Mol. Cancer Ther. 8 921 Boll et al. (2009), Heat shock protein 90 inhibitor BIIB021 (CNF2024) depletes NF-kappaB and sensitizes Hodgkin’s lymphoma cells for natural killer cell-mediated cytotoxicity; Clin. Cancer Res. 15 5108 Zhang et al. (2010), BIIB021, a synthetic Hsp90 inhibitor, has broad application against tumors with acquired multidrug resistance; Int. J. Cancer 126 1226 Wang et al. (2014), BIIB021, a novel Hsp90 inhibitor, sensitizes esophageal squamous cell carcinoma to radiation; Biochem. Biophys. Res. Commun. 452 945

BIIB-021 Preparation Products And Raw materials

Raw materials

Preparation Products

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BIIB-021 Suppliers

Canada 1 China 109 India 3 Japan 1 United Kingdom 2 United States 19 Global 135

AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2784
Advantage: 58

ApexBio Technology LLC

Tel: +1-832-696-8203
Fax: +1-832-641-3177
Email: info@apexbt.com
Country: United States
ProdList: 477
Advantage: 60

Target molecule Corp.

Tel: 857-239-0968
Fax: 857-239-8801
Email: service1@targetmol.com
Country: United States
ProdList: 2559
Advantage: 60

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4662
Advantage: 60

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 19892
Advantage: 58

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6393
Advantage: 58

Cckinase, Inc.

Tel: +1 (732)236-3202
Email: sales@cckinase.com
Country: United States
ProdList: 2738
Advantage: 58

Aladdin Scientific

Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57511
Advantage: 58

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View Lastest Price from BIIB-021 manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: BIIB-021 848695-25-0
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-13

848695-25-0, BIIB-021Related Search:

NOTUMib-1 AZ20 BI 2536 Imiquimod PU-H71 Onalespib PD 0332991 HCl 17-AAG Ganetespib Olaparib

CNF2024

9-[2-(2,2-diMethyl-propylaMino)ethyl]-8-(2-iodo-5-Methoxy-phenylsulfanyl)-9H-purin-6-ylaMine

CNF-2024EC102

9H-Purin-2-aMine, 6-chloro-9-[(4-Methoxy-3,5-diMethyl-2-pyridinyl)Methyl]-

6-chloro-9-((4-Methoxy-3,5-diMethylpyridin-2-yl)Methyl)-9H-purin-2-aMine

BIIB-021

BIIB021/CNF2024

6-Chloro-9-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]-9H-purin-2-amine

6-CHLORO-9-[(4-METHOXY-3,5-DIMETHYLPYRIDIN-2-YL)METHYL]PURIN-2-AMINE

6-Chloro-9-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]-9H-purin-2-amine BIIB 021

BIIB 021 6-Chloro-9-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]-9H-purin-2-amine

BIIB021(CNF2024)BIIB021

BIIB 021 (This product is only available in Japan.)

BIIB021;BIIB-021; BIIB 021

CNF 2024 - BIIB 021

CNF2024; BIIB-021; BIIB 021; CNF 2024; CNF-2024

CS-479

BIIB-021 USP/EP/BP

BIIB 021, ≥98%

BIIB021 BIIB-021

848695-25-0

C14H15ClN6O

Aromatics

Heterocycles

Inhibitors

Intermediates & Fine Chemicals

Pharmaceuticals

Antineoplastic

Inhibitor