ChemicalBook > CAS DataBase List > 4-[3-(Trifluoromethyl)-2-pyridinyl]-N-[5-(trifluoromethyl)-2-pyridinyl]-1-piperazinecarboxamide

4-[3-(Trifluoromethyl)-2-pyridinyl]-N-[5-(trifluoromethyl)-2-pyridinyl]-1-piperazinecarboxamide

Product Name: 4-[3-(Trifluoromethyl)-2-pyridinyl]-N-[5-(trifluoromethyl)-2-pyridinyl]-1-piperazinecarboxamide
CAS No.: 821768-06-3
Chemical Name: 4-[3-(Trifluoromethyl)-2-pyridinyl]-N-[5-(trifluoromethyl)-2-pyridinyl]-1-piperazinecarboxamide
Synonyms: JNJ 17203212;JNJ-17203212 (JNJ17203212;JNJ-17203212, 10 mM in DMSO;N1-(3-Trifluoromethylpyrid-2-yl)-N4-(4-trifluoromethylpyrid-2-yl)carbamoylpiperazine;4-(3-(Trifluoromethyl)pyridin-2-yl)-N-(5-(trifluoromethyl)pyridin-2-yl)piperazine-1-carboxamide;4-[3-(Trifluoromethyl)-2-pyridinyl]-N-[5-(trifluoromethyl)-2-pyridinyl]-1-piperazinecarboxamide;1-PiperazinecarboxaMide, 4-[3-(trifluoroMethyl)-2-pyridinyl]-N-[5-(trifluoroMethyl)-2-pyridinyl]-;4-[3-(TRIFLUOROMETHYL)-PYRIDIN-2-YL]-N-[5-(TRIFLUOROMETH YL)-PYRIDIN-2-YL]-1-PIPERAZINECARBOXAMIDE;management,inhibit,pain,migrainem,Transient receptor potential channels,TRP Channel,JNJ-17203212,JNJ17203212,Inhibitor,JNJ 17203212
CBNumber: CB62518945
Molecular Formula: C17H15F6N5O
Formula Weight: 419.32
MOL File: 821768-06-3.mol

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4-[3-(Trifluoromethyl)-2-pyridinyl]-N-[5-(trifluoromethyl)-2-pyridinyl]-1-piperazinecarboxamide Property

storage temp.: Inert atmosphere,Room Temperature
solubility: DMSO: >20mg/mL
form: Powder
color: white to off-white

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 22-36
Safety Statements: 26
RIDADR: UN 2811 6.1 / PGIII
HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H319Causes serious eye irritation

Precautionary statements

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Tocris

Product number: 3361
Product name: JNJ 17203212
Purity: ≥99%(HPLC)
Packaging: 10
Price: $191
Updated: 2021/12/16

Tocris

Product number: 3361
Product name: JNJ 17203212
Purity: ≥99%(HPLC)
Packaging: 50
Price: $802
Updated: 2021/12/16

TRC

Product number: J211358
Product name: JNJ 17203212
Packaging: 25mg
Price: $265
Updated: 2021/12/16

ChemScene

Product number: CS-5611
Product name: JNJ 17203212
Purity: 99.94%
Packaging: 25mg
Price: $360
Updated: 2021/12/16

Apolloscientific

Product number: BISN0031
Product name: JNJ 17203212
Purity: 99%
Packaging: 25mg
Price: $434
Updated: 2021/12/16

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4-[3-(Trifluoromethyl)-2-pyridinyl]-N-[5-(trifluoromethyl)-2-pyridinyl]-1-piperazinecarboxamide Chemical Properties,Usage,Production

Uses

JNJ 17203212 is a high affinity TRPV1 receptor antagonist.

in vivo

JNJ-17203212 (0.3 mg/kg; i.v.) dose-dependently reduces inflammatory soup (IS)-induced the immediate early gene c-fos expression^[2].
JNJ-17203212 completely blocks capsaicin-induced CGRP (the neurotransmitter calcitonin gene-related peptide) release in a dose-dependent manner^[2].

Animal Model:	Male Sprague-Dawley rats (260-300 g)^[2]
Dosage:	0.3 mg/kg
Administration:	Intravenous injection
Result:	Had a dose-dependent effect on the elevated c-fos expression that occurred after intracisternal injection of IS.

IC 50

TRPV1

storage

Store at +4°C

4-[3-(Trifluoromethyl)-2-pyridinyl]-N-[5-(trifluoromethyl)-2-pyridinyl]-1-piperazinecarboxamide Preparation Products And Raw materials

Raw materials

Preparation Products

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4-[3-(Trifluoromethyl)-2-pyridinyl]-N-[5-(trifluoromethyl)-2-pyridinyl]-1-piperazinecarboxamide Suppliers

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821768-06-3, 4-[3-(Trifluoromethyl)-2-pyridinyl]-N-[5-(trifluoromethyl)-2-pyridinyl]-1-piperazinecarboxamideRelated Search:

JNJ-38158471 JNJ-38877605-d1 JNJ-10198409 JNJ7777120 JNJ-64619178 jnj39758979 MELK-T1(JNJ-47117096) JNJ-632

1-PiperazinecarboxaMide, 4-[3-(trifluoroMethyl)-2-pyridinyl]-N-[5-(trifluoroMethyl)-2-pyridinyl]-

N1-(3-Trifluoromethylpyrid-2-yl)-N4-(4-trifluoromethylpyrid-2-yl)carbamoylpiperazine

4-[3-(Trifluoromethyl)-2-pyridinyl]-N-[5-(trifluoromethyl)-2-pyridinyl]-1-piperazinecarboxamide

JNJ 17203212

JNJ-17203212 (JNJ17203212

management,inhibit,pain,migrainem,Transient receptor potential channels,TRP Channel,JNJ-17203212,JNJ17203212,Inhibitor,JNJ 17203212

4-(3-(Trifluoromethyl)pyridin-2-yl)-N-(5-(trifluoromethyl)pyridin-2-yl)piperazine-1-carboxamide

4-[3-(TRIFLUOROMETHYL)-PYRIDIN-2-YL]-N-[5-(TRIFLUOROMETH YL)-PYRIDIN-2-YL]-1-PIPERAZINECARBOXAMIDE

JNJ-17203212, 10 mM in DMSO

821768-06-3

C17H15F6N5O