ICG-001

ChemicalBook > CAS DataBase List > ICG-001

Product Name: ICG-001
CAS No.: 847591-62-2
Chemical Name: ICG-001
Synonyms: ICG-1;ICG-001;CS-1928;ICG001 isomer;ICG-001/ICG001;ICG 001, >=98%;ICG-001 isomer;PRI-724 isomer;ICG 001 isomer.;ICG001, 10 mM in DMSO
CBNumber: CB62520386
Molecular Formula: C33H32N4O4
Formula Weight: 548.63158
MOL File: 847591-62-2.mol

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ICG-001 Property

Density: 1.37
storage temp.: +2C to +8C
solubility: Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 25 mg/ml).
form: Off-white powder
color: Off-white
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 5.04712
Product name: β-Catenin/Tcf Inhibitor VI, ICG-001 - CAS 847591-62-2 - Calbiochem
Packaging: 10MG
Price: $280
Updated: 2024/03/01

Cayman Chemical

Product number: 16257
Product name: ICG-001
Purity: ≥98%
Packaging: 1mg
Price: $28
Updated: 2021/12/16

Cayman Chemical

Product number: 16257
Product name: ICG-001
Purity: ≥98%
Packaging: 5mg
Price: $63
Updated: 2021/12/16

Cayman Chemical

Product number: 16257
Product name: ICG-001
Purity: ≥98%
Packaging: 10mg
Price: $112
Updated: 2021/12/16

Cayman Chemical

Product number: 16257
Product name: ICG-001
Purity: ≥98%
Packaging: 25mg
Price: $245
Updated: 2021/12/16

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ICG-001 Chemical Properties,Usage,Production

Description

ICG-001 (847591-62-2) inhibits TCF/β-catenin mediated transcription by specifically blocking β-catenin/CBP interaction

Uses

(S,S)-ICG 001 is a β-turn peptidomimetic molecule inhibitor of β-catenin-Tcf-mediated transcription.

Definition

ChEBI: (6S,9aS)-6-[(4-hydroxyphenyl)methyl]-8-(1-naphthalenylmethyl)-4,7-dioxo-N-(phenylmethyl)-3,6,9,9a-tetrahydro-2H-pyrazino[1,2-a]pyrimidine-1-carboxamide is a peptide.

General Description

A cell-permeable pyrazinopyrimidinecarboxamide that competes against β-catenin for CBP (CREB-binding protein) binding and selectively prevents CBP- but not p300-, dependent TCF/β-catenin transcriptional regulations both in cultures in vitro (5 to 25 μM) and in mice in vivo (5 mg/kg/day via osmotic pump infusion), while not affecting CBP-dependent transcriptional activities mediated by the AP-1 or CRE complex. Shown to reactivate p300//TCF/β-catenin-mediated neuronal differentiation upon NGF stimulation in PS-1 L286V mutant-expressing PC-12 cultures and be efficacious in alleviating bleomycin- (0,08 units/50 μL/mouse; administered intranasally; Cat. No. 203401) induced pulmonary fibrosis in mice.

Biochem/physiol Actions

Cell permeable: yes

References

1) Emami?et al.?(2004),?A small molecule inhibitor of β-catenin/CREB-binding protein transcription;? Proc. Natl. Acad. Sci. USA,?101?12682 2) Zhou?et al.?(2012), Interactions?between β-catenin and transforming growth factor-β signaling pathways mediate epithelial-mesenchymal transition and are dependent on the transcription co-activator cAMP-response element-binding protein (CERB)-binding protein (CBP);??J. Biol. Chem.,?287?7026

ICG-001 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from ICG-001 manufacturers

Career Henan Chemical Co

Product: ICG-001 847591-62-2
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 20kg
Release date: 2019-12-23

847591-62-2, ICG-001Related Search:

TYRPHOSTIN AG 1296 S-Trityl-L-cysteine ZM 336372 LFM-A13

ICG-001

2H-Pyrazino[1,2-a]pyriMidine-1(6H)-carboxaMide, hexahydro-6-[(4-hydroxyphenyl)Methyl]-8-(1-naphthalenylMethyl)-4,7-dioxo-N-(phenylMethyl)-, (6S,9aS)-

ICG-1

(6S,9aS)-Hexahydro-6-[(4-hydroxyphenyl)methyl]-8-(1-naphthalenylmethyl)-4,7-dioxo-N-(phenylmethyl)-2H-pyrazino[1,2-a]pyrimidine-1(6H)-carboxamide

ICG-001/ICG001

(6S,9aS)-Hexahydro-6-[(4-hydroxyphenyl)methyl]-8-(1-naphthalenylmethyl)-4,7-dioxo-N-(phenylmethyl)-2H-pyrazino[1,2-a]pyrimidine-1(6H)-carboxamide ICG001

ICG 001, >=98%

ICG-001;ICG 001;ICG001

(6S,9AS)-6-(4-hydroxybenzyl)-N-benzyl-8-(naphthalen-1-ylmethyl)-4,7-dioxo-hexahydro-2H-pyrazin

ICG 001 isomer.

ICG001 isomer

ICG-001 isomer

CS-1928

β-Catenin/Tcf Inhibitor VI, ICG-001 - CAS 847591-62-2 - Calbiochem

PRI-724 isomer

ICG001, 10 mM in DMSO

847591-62-2

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