PYR 41

Product Name: PYR 41
CAS No.: 418805-02-4
Chemical Name: PYR 41
Synonyms: PYR 41;CS-1129;PYR 41, >=98%;PYR41; PYR-41;PYR-41 ，S7129;PYR 41 USP/EP/BP;PYR-41, 10 mM in DMSO;PYR-41, Ubiquitin-activating enzyme (E1) inhibitor;Ethyl 4-(4-((5-nitrofuran-2-yl)methylene)-3,5-dioxopyrazolidin-1-yl)benzoate;ethyl 4-[(4Z)-4-[(5-nitrofuran-2-yl)methylidene]-3,5-dioxopyrazolidin-1-yl]benzoate
CBNumber: CB62535692
Molecular Formula: C17H13N3O7
Formula Weight: 371.3
MOL File: 418805-02-4.mol

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PYR 41 Property

Melting point:: 228 - 235°C
Density: 1.486±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: Soluble in DMSO at 5mg/ml with warming
form: powder
pka: 7.43±0.20(Predicted)
color: red to brown
Sensitive: Light Sensitive
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 week.
InChI: InChI=1S/C17H13N3O7/c1-2-26-17(23)10-3-5-11(6-4-10)19-16(22)13(15(21)18-19)9-12-7-8-14(27-12)20(24)25/h3-9H,2H2,1H3,(H,18,21)
InChIKey: ARGIPZKQJGFSGQ-LCYFTJDESA-N
SMILES: C(OCC)(=O)C1=CC=C(N2C(=O)C(=CC3=CC=C([N+]([O-])=O)O3)C(=O)N2)C=C1

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Safety

Hazard Codes: Xn
Risk Statements: 22-43
Safety Statements: 36/37
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: N2915
Product name: PYR-41
Purity: ≥98% (HPLC), powder
Packaging: 5mg
Price: $103
Updated: 2025/07/31

Sigma-Aldrich

Product number: N2915
Product name: PYR-41
Purity: ≥98% (HPLC), powder
Packaging: 25mg
Price: $313
Updated: 2025/07/31

Cayman Chemical

Product number: 15226
Product name: PYR41
Purity: ≥95%
Packaging: 1mg
Price: $26
Updated: 2024/03/01

Cayman Chemical

Product number: 15226
Product name: PYR41
Purity: ≥95%
Packaging: 5mg
Price: $51
Updated: 2024/03/01

Cayman Chemical

Product number: 15226
Product name: PYR41
Purity: ≥95%
Packaging: 10mg
Price: $90
Updated: 2024/03/01

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PYR 41 Chemical Properties,Usage,Production

Description

Pyr41 (418805-02-4) inhibits ubiquitin activating enzyme E1 (>60% inhibition at 10 μM) with little or no activity against E2 or E3. Cell permeable

Uses

PYR 41 is an irreversible and cell-permeable UBE1 inhibitor.

Definition

ChEBI: PYR-41 is an ethyl ester resulting from the formal condensation of the carboxy group of 4-{4-[(5-nitrofuran-2-yl)methylidene]-3,5-dioxopyrazolidin-1-yl}benzoic acid with ethanol. It is an irreversible and cell-permeable inhibitor of ubiquitin-activating enzyme E1. It has a role as an EC 6.2.1.45 (E1 ubiquitin-activating enzyme) inhibitor and an antineoplastic agent. It is an ethyl ester, a member of furans, a C-nitro compound, a member of pyrazolidines and a benzoate ester.

Biochem/physiol Actions

PYR-41 is a cell permeable inhibitor of Ubiquitin activating enzyme (E1) with little or no activity against E3, E2, or caspase enzymatic activity.

in vitro

in addition to blocking ubiquitylation, pyr-41 was found to increase total sumoylation in cells. pyr-41 could attenuate cytokine-mediated nuclear factor-kbactivation. this correlated with inhibition of nonproteasomal ubiquitylation of traf6, which is important to ikbkinase activation. pyr-41 also prevented the downstream ubiquitylation and proteasomal degradation of ikba. moreover, pyr-41 has demonstrated effective uae e1 inhibition as well as some off-target inhibition of the other ubiquitin regulatory enzymes and signal-transducing proteins, suggesting it is a nonspecific inhibitor [1].

storage

Store at -20°C

References

[1] YILI YANG. Inhibitors of ubiquitin-activating enzyme (E1), a new class of potential cancer therapeutics.[J]. Cancer research, 2007, 67 19: 9472-9481. DOI:10.1158/0008-5472.can-07-0568
[2] LIXIN MI. Cancer preventive isothiocyanates induce selective degradation of cellular alpha- and beta-tubulins by proteasomes.[J]. The Journal of Biological Chemistry, 2009, 284 25: 17039-17051. DOI:10.1074/jbc.m901789200
[3] TOMOHIKO MAEHAMA. Nucleolar stress induces ubiquitination-independent proteasomal degradation of PICT1 protein.[J]. The Journal of Biological Chemistry, 2014, 289 30: 20802-20812. DOI:10.1074/jbc.m114.571893

PYR 41 Preparation Products And Raw materials

Raw materials

Preparation Products

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PYR 41 Suppliers

China 113 India 1 United Kingdom 3 United States 16 Global 133

Target molecule Corp.

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View Lastest Price from PYR 41 manufacturers

Career Henan Chemical Co

Product: PYR 41 418805-02-4
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 200kg
Release date: 2019-12-25

418805-02-4, PYR 41Related Search:

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PYR 41

4-[4-[(5-Nitro-2-furanyl)methylene]-3,5-dioxo-1-pyrazolidinyl]benzoic acid ethyl ester

Benzoic acid, 4-[4-[(5-nitro-2-furanyl)methylene]-3,5-dioxo-1-pyrazolidinyl]-, ethyl ester

4-[4-[(5-Nitro-2-furanyl)methylene]-3,5-dioxo-1-pyrazolidinyl]benzoic acid ethyl ester PYR 41

PYR 41 4-[4-[(5-Nitro-2-furanyl)methylene]-3,5-dioxo-1-pyrazolidinyl]benzoic acid ethyl ester

4[4-(5-Nitro-furan-2-ylmethylene)-3,5-dioxo-pyrazolidin-1-yl]-benzoic acid ethyl ester

PYR 41, >=98%

CS-1129

PYR41; PYR-41

PYR 41 USP/EP/BP

ethyl 4-[(4Z)-4-[(5-nitrofuran-2-yl)methylidene]-3,5-dioxopyrazolidin-1-yl]benzoate

Ethyl 4-(4-((5-nitrofuran-2-yl)methylene)-3,5-dioxopyrazolidin-1-yl)benzoate

E3 ligating enzyme,E1 activating enzyme,E1/E2/E3 Enzyme,Inhibitor,PYR-41,Ubiquitin conjugating enzyme,Apoptosis,E2 conjugating enzyme,Ubiquitin activating enzyme,Ubiquitin ligase,inhibit

PYR-41, Ubiquitin-activating enzyme (E1) inhibitor

PYR-41, 10 mM in DMSO

PYR-41 ，S7129

418805-02-4

Inhibitors