ChemicalBook > CAS DataBase List > FH 535

FH 535

Product Name
FH 535
CAS No.
108409-83-2
Chemical Name
FH 535
Synonyms
FH 535;CS-1433;FH 535(FH-535);FH 535 USP/EP/BP;FH535;FH 535;FH-535;β-Catenin/Tcf Inhibitor, FH535;2,5-Dichloro-N-(2-Methyl-4-nitrophenyl)benzenesulfonaMide;N-(2-Methyl-4-nitrophenyl)-2,5-dichlorobenzenesulfonaMide;Benzenesulfonamide, 2,5-dichloro-N-(2-methyl-4-nitrophenyl)-;β-Catenin/Tcf Inhibitor, FH535 - CAS 108409-83-2 - Calbiochem
CBNumber
CB62552602
Molecular Formula
C13H10Cl2N2O4S
Formula Weight
361.2
MOL File
108409-83-2.mol
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FH 535 Property

Melting point:
141-142℃
Boiling point:
526.3±60.0 °C(Predicted)
Density 
1.566±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: soluble20mg/mL
form 
Yellow solid
pka
5.83±0.10(Predicted)
color 
Tan
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
InChIKey
AXNUEXXEQGQWPA-UHFFFAOYSA-N
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Safety

Hazard Codes 
Xi
Risk Statements 
41
Safety Statements 
36
WGK Germany 
3
HS Code 
29350090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
F5682
Product name
FH535
Purity
≥98% (HPLC)
Packaging
5mg
Price
$109
Updated
2024/03/01
Sigma-Aldrich
Product number
219330
Product name
β-Catenin/Tcf Inhibitor, FH535
Packaging
10mg
Price
$144
Updated
2024/03/01
Cayman Chemical
Product number
18001
Product name
FH535
Purity
≥95%
Packaging
5mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
18001
Product name
FH535
Purity
≥95%
Packaging
10mg
Price
$84
Updated
2024/03/01
Sigma-Aldrich
Product number
F5682
Product name
FH535
Purity
≥98% (HPLC)
Packaging
25mg
Price
$419
Updated
2024/03/01
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FH 535 Chemical Properties,Usage,Production

Description

FH-535 (108409-83-2) suppresses Wnt/β-catenin signaling. It antagonizes PPARγ and PPARδ ligand-dependent activation which is mediated by inhibition of recruitment of the coactivators β-catenin and GRIP1 but not the corepressors NCoR and SMRT.1?Inhibits the migration and growth of breast cancer cell lines2 as well as colon, lung and liver cell lines1. FH-535 is a useful tool for probing the involvement of Wnt signaling pathway.3,4

Chemical Properties

Dark Yellow Solid

Uses

A cell-permeable compound that inhibits Wnt/β-catenin and PPAR

Uses

Antagonizes Wnt/β-catenin/Tcf-mediated transcription as well as PPARγ and δ activity. Able to inhibit the recruitment of the co-activators β-catenin and GRIP1, both of which are activators for both pathways.

Definition

ChEBI: 2,5-dichloro-N-(2-methyl-4-nitrophenyl)benzenesulfonamide is a sulfonamide.

Biochem/physiol Actions

FH535 has the ability to block the development of colon cancer cells. It can change several cancer-associated biological processes. FH535 can also prevent PARylation of Axin2 in osteosarcoma cells.

storage

+4°C

References

1) Handeli et al. (2008), A small-molecule inhibitor of Tcf/beta-catenin signaling down-regulates PPARgamma and PPARdelta activities; Mol. Cancer Ther., 7 521 2) Iida et al. (2012), FH535 inhibited migration and growth of breast cancer cells; PLoS One, 7 e44418 3) Frewer et al. (2013), A role for WISP2 in colorectal cancer cell invasion and motility; Cancer Genomics Proteomics, 10 187 4) Polk et al. (2012), FH535 potentiation of cigarette smoke condensate cytotoxicity is associated with changes in β-catenin and EGR-1 signaling; Int. J. Toxicol., 31 380 5) Morita and Hayashi (2018), Tumor Progression is Mediated by Thymosin-β4 through a TGFβ/MRTF Signaling Axis; Mol. Cancer Res. 16(5) 880

FH 535 Preparation Products And Raw materials

Raw materials

Preparation Products

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FH 535 Suppliers

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View Lastest Price from FH 535 manufacturers

Career Henan Chemical Co
Product
FH 535 108409-83-2
Price
US $9.80/KG
Min. Order
1g
Purity
≥99%
Supply Ability
100kg
Release date
2020-01-08

108409-83-2, FH 535Related Search:

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  • β-Catenin/Tcf Inhibitor, FH535 - CAS 108409-83-2 - Calbiochem
  • CS-1433
  • FH 535
  • N-(2-Methyl-4-nitrophenyl)-2,5-dichlorobenzenesulfonaMide
  • 2,5-Dichloro-N-(2-Methyl-4-nitrophenyl)benzenesulfonaMide
  • 2,5-Dichloro-N-(2-methyl-4-nitrophenyl)benzenesulfonamide FH535
  • β-Catenin/Tcf Inhibitor, FH535
  • FH 535(FH-535)
  • FH535;FH 535;FH-535
  • FH535, 98%, a cell-permeable compound that inhibits Wnt/β-catenin and PPAR
  • Benzenesulfonamide, 2,5-dichloro-N-(2-methyl-4-nitrophenyl)-
  • FH 535 USP/EP/BP
  • FH 535,Beta catenin,β-catenin,FH535,inhibit,FH-535,PPAR,Wnt,Inhibitor,Peroxisome proliferator-activated receptors
  • 108409-83-2
  • API
  • Aromatics
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals