SteMRegenin 1

Product Name: SteMRegenin 1
CAS No.: 1227633-49-9
Chemical Name: SteMRegenin 1
Synonyms: SR1;SR-1;CS-873;SR-1;SR1;Novartis SR1;etMRegenin 1;SteMRegenin 1;SetmRegenin 1;SetMEegenin 1;SR 1;SR-1;SR1
CBNumber: CB62560979
Molecular Formula: C24H23N5OS
Formula Weight: 429.54
MOL File: 1227633-49-9.mol

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SteMRegenin 1 Property

Boiling point:: 604.9±65.0 °C(Predicted)
Density: 1.36±0.1 g/cm3(Predicted)
storage temp.: +2C to +8C
solubility: Soluble in DMSO (up to 10 mg/ml).
form: White solid
pka: 10.03±0.15(Predicted)
color: Off-white
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
InChIKey: BGFHMYJZJZLMHW-UHFFFAOYSA-N

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Safety

Hazard Codes: Xn
Risk Statements: 22
HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 182706
Product name: AhR Antagonist II, SR1
Packaging: 5mg
Price: $208
Updated: 2024/03/01

Cayman Chemical

Product number: 10625
Product name: StemRegenin 1
Purity: ≥98%
Packaging: 1mg
Price: $29
Updated: 2024/03/01

Cayman Chemical

Product number: 10625
Product name: StemRegenin 1
Purity: ≥98%
Packaging: 5mg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 10625
Product name: StemRegenin 1
Purity: ≥98%
Packaging: 10mg
Price: $131
Updated: 2024/03/01

ChemScene

Product number: CS-1643
Product name: StemRegenin1
Purity: 99.50%
Packaging: 50mg
Price: $192
Updated: 2021/12/16

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SteMRegenin 1 Chemical Properties,Usage,Production

Description

SR1 (1227633-49-9)?extends the pluripotency of hematopoietic stem cells by antagonizing the arylhydrocarbon receptor (AhR), IC50?= 127?nM.1?The effect is dose-dependent and reversible. Displays a biphasic effect on CD34-negative cells with low does (1 μM) enhancing proliferation and high does (>5 μM) repressing proliferation.2?May be used to generate progenitor T cells3?from HSPCs as well as NK cells for immuno-oncology studies4.

Application

StemRegenin 1 can also be used to treat infectious diseases such as HIV/AIDS, malaria, and tuberculosis. The mechanism by which StemRegenin 1 stimulates the production of new red blood cells is not well understood; however, it appears to work through activation of JAK1. This protein inhibits the polymerase chain reaction (PCR), which is an enzyme that increases the rate at which DNA copies are made from a template molecule. Inhibitors of this enzyme have been shown to prevent infection with Human Immunodeficiency Virus (HIV) in vitro.

General Description

A cell-permeable purine compound that acts as a high affinity AhR antagonist (IC₅₀ = 127 nM against 3 nM TCDD-induced luciferase reporter activity in HepG2 cultures), but not a panel of 61 kinases. AhR expression and function knockouts by shRNAs, CH-223191 (Cat. No. 182705), or SR1 treatment all result in enhanced and sustained CD34⁺ population in long-term proliferating/expanding cultures of cord blood-derived HSCs (hematopoietic setem cells) in serum-free media containing Tpo (Cat. No. 605218), SCF (Cat. No. 569600), Flt3 Ligand (Cat. No. 343010), and IL-6 (Cat. No. 407652) in a reversible manner. SR1 is reactive toward human, monkey, and canine, but not rat or murine, species.

Uses

StemRegenin 1 is a plant-derived stem cell factor that is potent inducers of hematopoietic stem cells. It has been shown to stimulate the differentiation and proliferation of primary cells, such as human umbilical cord blood cells and bone marrow cells, into mature erythrocytes and leukocytes.

target

AhR

storage

Store at -20°C

References

1) Boitano?et al.?(2010),?Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells; Science,?329?1354 2) Tao?et al.?(2017),?StemRegenin 1 selectively promotes expansion of Multipotent Hematopoietic Progenitors derived from Human Embryonic Stem Cells; J. Stem Cells Regen. Med.,?13?75 3) Singh?et al.?(2019),?Generation and function of progenitor T cells from stemRegenin-1-expanded CD34+ human hematopoietic progenitor cells;?Blood Adv,?3?2934 4) Hoogstad-van Evert?et al.?(2017),?Umbilical cord blood CD34+ progenitor-derived NK cells efficiently kill ovarian cancer spheroids and intraperitoneal tumors in NOD/SCID/IL2Rgnull?mice; Oncoimmunology,?6(8)?e1320630

SteMRegenin 1 Preparation Products And Raw materials

Raw materials

Preparation Products

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SteMRegenin 1 Suppliers

China 85 China Hong Kong 1 India 1 United Kingdom 1 United States 16 Global 104

ChemCell Biomedicine Co.,Ltd.

Tel: 020-13556033878 2965585218 13556033878
Fax: 0086-0757-85406358
Email: chemcell@hotmail.com
Country: China
ProdList: 369
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Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
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Advantage: 55

Chemsky (shanghai) International Co.,Ltd

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 15421
Advantage: 60

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: sales@meilune.com
Country: China
ProdList: 4647
Advantage: 58

Shanghai Topbiochem Technology Co., Ltd

Tel: +86-21-60341587
Fax: +86-21-61294319
Email: sales@topbiochem.com
Country: China
ProdList: 6181
Advantage: 58

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7553
Advantage: 61

UHN Shanghai Research & Development Co., Ltd.

Tel: 021-58958002 18930822973
Fax: +86 (21) 5895-8628
Email: SALES@UHNSHANGHAI.COM
Country: China
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MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4863
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EnliPharma Technology Co., Ltd

Tel: 0551-66399836 18955197623
Email: sales@enlipharma.com
Country: China
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Guangzhou Isun Pharmaceutical Co., Ltd

Tel: 020-39119399 18927568969
Fax: 020-39119999
Email: isunpharm@qq.com
Country: China
ProdList: 4428
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View Lastest Price from SteMRegenin 1 manufacturers

Career Henan Chemical Co

Product: SteMRegenin 1 1227633-49-9
Price: US $2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2018-12-24

Career Henan Chemical Co

Product: SteMRegenin 1 1227633-49-9
Price: US $2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2018-12-24

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Novartis SR1

SteMRegenin 1 (SR1)

SetMEegenin 1

4-[2-[[2-Benzo[b]thien-3-yl-9-(1-methylethyl)-9H-purin-6-yl]amino]ethyl]phenol

SetmRegenin 1

4-[2-[[2-Benzo[b]thien-3-yl-9-(1-methylethyl)-9H-purin-6-yl]amino]ethyl]phenol StemRegenin 1

SteMRegenin 1 4-[2-[[2-Benzo[b]thien-3-yl-9-(1-methylethyl)-9H-purin-6-yl]amino]ethyl]phenol

SteMRegenin 1

4-(2-(2-(benzo[b]thiophen-3-yl)-9-isopropyl-9H-purin-6-ylaMino)ethyl)phenol

SR1

SR-1

SR-1;SR1

Phenol, 4-[2-[[2-benzo[b]thien-3-yl-9-(1-Methylethyl)-9H-purin-6-yl]aMino]ethyl]-

etMRegenin 1

StemRegenin 1, Free base

StemRegenin 1, >=98%

AhR Antagonist II, SR1

AhR Antagonist II, SR1 - CAS 1227633-49-10 - Calbiochem

SetmEegenin 1, >98%

SR 1;SR-1;SR1

CS-873

SteMRegenin 1 USP/EP/BP

1227633-49-9

Antineoplastic

apis

Inhibitors