4-Bromo-2-fluorophenol
- Product Name
- 4-Bromo-2-fluorophenol
- CAS No.
- 2105-94-4
- Chemical Name
- 4-Bromo-2-fluorophenol
- Synonyms
- 4-Bromo-2-fluorophen;4-Brom-2-Fluorphenol;2-Fluor-4 bromophenol;2-Fluoro-4-BroMophonel;2-Fluoro-4-Bromophenol;4-BROMO-2-FLUOROPHENOL;2-Bromo-2-fluorophenol;4-Bromo-2-fluorophenol98%;Phenol, 4-bromo-2-fluoro-;4-Bromo-2-fluorophenol >
- CBNumber
- CB6257615
- Molecular Formula
- C6H4BrFO
- Formula Weight
- 191
- MOL File
- 2105-94-4.mol
4-Bromo-2-fluorophenol Property
- Boiling point:
- 79 °C/7 mmHg (lit.)
- Density
- 1.744 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.566(lit.)
- Flash point:
- 210 °F
- storage temp.
- Inert atmosphere,Room Temperature
- form
- Liquid
- pka
- 8.14±0.18(Predicted)
- Specific Gravity
- 1.744
- color
- Clear colorless to brown
- BRN
- 1861281
- InChI
- InChI=1S/C6H4BrFO/c7-4-1-2-6(9)5(8)3-4/h1-3,9H
- InChIKey
- RYVOZMPTISNBDB-UHFFFAOYSA-N
- SMILES
- C1(O)=CC=C(Br)C=C1F
- CAS DataBase Reference
- 2105-94-4(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-22
- Safety Statements
- 26-37/39-36/37/39
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29071990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 316296
- Product name
- 4-Bromo-2-fluorophenol
- Purity
- 98%
- Packaging
- 5g
- Price
- $25
- Updated
- 2023/01/07
- Product number
- 316296
- Product name
- 4-Bromo-2-fluorophenol
- Purity
- 98%
- Packaging
- 25g
- Price
- $60.8
- Updated
- 2023/01/07
- Product number
- B1835
- Product name
- 4-Bromo-2-fluorophenol
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $31
- Updated
- 2025/07/31
- Product number
- B1835
- Product name
- 4-Bromo-2-fluorophenol
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $92
- Updated
- 2025/07/31
- Product number
- B692828
- Product name
- 4-Bromo-2-fluorophenol
- Packaging
- 5g
- Price
- $75
- Updated
- 2021/12/16
4-Bromo-2-fluorophenol Chemical Properties,Usage,Production
Chemical Properties
CLEAR COLORLESS TO BROWNISH LIQUID
Uses
4-Bromo-2-fluorophenol can be used as a starting material for the synthesis of:
- 4-Bromo-2-fluoro-6-iodoanisole via iodination and methylation.
- 2-Phenylpyran-4-ones for active cyclooxygenase-2 inhibitor evaluation.
- 1,4-Disubstituted 3-cyano-2-pyridones.
- Dicationic imidazolium-based compounds.
Synthesis
367-12-4
2105-94-4
Example 5: Preparation of methyl 2-[4-(4-bromo-2-fluorophenoxy)phenoxy]propionate (STR29) 1. 2-Fluorophenol (22.4 g, 0.2 mol) was dissolved in dichloromethane (250 mL) under ice bath conditions and cooled to about 3 °C. 2. 2. bromine (31.97 g, 0.2 mol) was added slowly, keeping the reaction temperature at ice bath conditions. 3. the reaction mixture was stirred at ice bath temperature for 2 hours, followed by continued stirring at room temperature for 1 hour. 4. the reaction mixture was quenched by pouring into water (600 mL) containing excess sodium bisulfite. 5. The organic phase was separated and the aqueous phase was washed with additional dichloromethane (200 mL). 6. The organic extracts were combined, washed with saturated sodium bicarbonate solution and subsequently dried over anhydrous magnesium sulfate. 7. The solvent was removed by evaporation to afford the target product 2-fluoro-4-bromophenol as a colorless oil (34.5 g, 90% yield). 8. The structure of the product was confirmed to be as expected by NMR hydrogen spectroscopy (CDCl3).
References
[1] Patent: US4642338, 1987, A
[2] Patent: US4725683, 1988, A
[3] Patent: US4808750, 1989, A
[4] Patent: US4550192, 1985, A
[5] Chemistry - A European Journal, 2017, vol. 23, # 5, p. 1044 - 1047
4-Bromo-2-fluorophenol Preparation Products And Raw materials
Raw materials
Preparation Products
4-Bromo-2-fluorophenol Suppliers
- Tel
- 800-4238616
- Fax
- +1-888-520-1075 / +1-503-283-1987
- sales@tciamerica.com
- Country
- Americas
- ProdList
- 23653
- Advantage
- 75
View Lastest Price from 4-Bromo-2-fluorophenol manufacturers
- Product
- 4-Bromo-2-fluorophenol 2105-94-4
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-10-24
- Product
- 4-Bromo-2-fluorophenol 2105-94-4
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-03-21
- Product
- 4-Bromo-2-fluorophenol 2105-94-4
- Price
- US $10.00-1.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 10 tons
- Release date
- 2023-10-23