ChemicalBook > CAS DataBase List > 6-CHLORO-2,3-DIHYDRO-1H-INDOLE

6-CHLORO-2,3-DIHYDRO-1H-INDOLE

Product Name: 6-CHLORO-2,3-DIHYDRO-1H-INDOLE
CAS No.: 52537-00-5
Chemical Name: 6-CHLORO-2,3-DIHYDRO-1H-INDOLE
Synonyms: NSC 87628;6-chloroindoline;6-CHLORO-2,3-DIHYDRO-1H-INDOLE;1H-INDOLE,6-CHLORO-2,3-DIHYDRO-
CBNumber: CB6263766
Molecular Formula: C8H8ClN
Formula Weight: 153.61
MOL File: 52537-00-5.mol

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6-CHLORO-2,3-DIHYDRO-1H-INDOLE Property

Boiling point:: 250.3±29.0 °C(Predicted)
Density: 1.214±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 4.32±0.20(Predicted)
Appearance: Off-white to gray Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC

Product number: C597745
Product name: 6-Chloro-2,3-dihydro-1H-indole
Packaging: 100mg
Price: $60
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC155067
Product name: 6-Chloro-2,3-dihydro-1H-indole
Packaging: 50mg
Price: $65
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC155067
Product name: 6-Chloro-2,3-dihydro-1H-indole
Packaging: 100mg
Price: $100
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC155067
Product name: 6-Chloro-2,3-dihydro-1H-indole
Packaging: 250mg
Price: $160
Updated: 2021/12/16

AK Scientific

Product number: W6731
Product name: 6-Chloro-2,3-dihydro-1H-indole
Packaging: 1g
Price: $237
Updated: 2021/12/16

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6-CHLORO-2,3-DIHYDRO-1H-INDOLE Chemical Properties,Usage,Production

Synthesis

17422-33-2

52537-00-5

General procedure for the synthesis of 6-chloroindoline from 6-chloroindole: 1. reduction of indole to indoline: 6-chloro-1H-indole (2 g, 0.013 mol) was dissolved in acetic acid (10 mL) under nitrogen protection. 2. Sodium cyanoborohydride (1.24 g, 1.5 eq.) was added to the above solution and the reaction was stirred at room temperature for 20 min. 3. Upon completion of the reaction, the reaction mixture was diluted with ethyl acetate. 4. The organic phase was separated by extraction using 5N aqueous sodium hydroxide solution. 5. The organic phase was dried with magnesium sulfate, filtered and concentrated to give the crude product 6-chloro-2,3-dihydro-1H-indole (2.35 g, 116% yield). 6. The product was analyzed by material spectrum (ES, m/z): 154.0 (M + 1).

References

[1] Patent: WO2003/76398, 2003, A2. Location in patent: Page/Page column 41
[2] Patent: US2011/21500, 2011, A1. Location in patent: Page/Page column 49
[3] Patent: JP2015/193573, 2015, A. Location in patent: Paragraph 0043
[4] Patent: WO2012/143726, 2012, A1. Location in patent: Page/Page column 129
[5] Journal of Medicinal Chemistry, 2015, vol. 58, # 16, p. 6574 - 6588

6-CHLORO-2,3-DIHYDRO-1H-INDOLE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 6-CHLORO-2,3-DIHYDRO-1H-INDOLE manufacturers

Career Henan Chemical Co

Product: 6-CHLORO-2,3-DIHYDRO-1H-INDOLE 52537-00-5
Price: US $1.00/g
Min. Order: 100g
Purity: 99%
Supply Ability: G/KG/T
Release date: 2019-12-20

52537-00-5, 6-CHLORO-2,3-DIHYDRO-1H-INDOLERelated Search:

6-Hydroxyindole 3-HYDROXY-1-PHENYL-6-PYRIDAZONE 6-Cyanoindole 6-cyanopyridine-3-boronic acid 6-CHLOROINDOLE-3-ACETONITRILE 6-chloropyrazine-2-carbonitrile 6-Cyanopyridine-2-carboxylic acid 6-Chloroindole 2,3-DIHYDRO-1H-INDOLE-6-CARBONITRILE HYDROCHLORIDE 6-Hydroxyindolin-2-one 6-CHLORO-1H-INDOLE-2-CARBOXYLIC ACID METHYL ESTER 1H-INDOLE-3-CARBOXYLIC ACID,6-CHLORO-,METHYL ESTER 6-Chloroindole-2-carboxylic acid 6-CHLOROINDOLE-3-CARBOXYLIC ACID 6-Chloro-5-(2-chloroethyl)oxindole 6-Chloroisatin 6-Chlorooxindole Ziprasidone Hydrochloride

6-CHLORO-2,3-DIHYDRO-1H-INDOLE

6-chloroindoline

NSC 87628

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52537-00-5