O-TOLUIDINE HYDROCHLORIDE Property

Melting point:

215-217 °C(lit.)

Boiling point:

242 °C

Density 

1.0968 (rough estimate)

refractive index 

1.5760 (estimate)

storage temp. 

2-8°C

solubility 

DMSO (Slightly), Methanol (Slightly), Water (Slightly)

color 

White to Grey

BRN 

3558629

Stability:

Stable. Incompatible with oxidizing agents, alkalies. Light and moisture sensitive.

InChIKey

OGVXWEOZQMAAIM-UHFFFAOYSA-N

CAS DataBase Reference

636-21-5(CAS DataBase Reference)

EPA Substance Registry System

o-Toluidine hydrochloride (636-21-5)

Safety

Hazard Codes 

T

Risk Statements 

45-20/21/22

Safety Statements 

53-36/37/39-45

RIDADR 

UN 2811 6.1/PG 2

WGK Germany 

3

RTECS 

XU7350000

HazardClass 

6.1(a)

PackingGroup 

II

HS Code 

2921430000

Hazardous Substances Data

636-21-5(Hazardous Substances Data)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H350May cause cancer

Precautionary statements

P201Obtain special instructions before use.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

O-TOLUIDINE HYDROCHLORIDE Chemical Properties,Usage,Production

Chemical Properties

white crystalline powder

Uses

o-Toluidine and o-toluidine hydrochloride are used primarily as intermediates in the manufacture of more than 90 dyes and pigments (NCI 1979, IARC 1982, 2000). They are used in acid-fast dyestuffs, azo pigments and dyes, triarylmethane dyes, sulfur dyes, and indigo compounds and as a photographic dye. o-Toluidine is also used as an intermediate for synthetic rubber and rubber vulcanizing chemicals, pharmaceuticals, and pesticides and as a curing agent in epoxy resin systems. Other minor uses of o-toluidine and its hydrochloride salt are as an intermediate in organic synthesis and as an ingredient in a clinical laboratory reagent for glucose and hemoglobin analyses.

Uses

o-Toluidine Chloride is a carcinogenic and toxic aromatic amine contained in hair dye, henna and dyed hair samples. Prilocaine USP Related Compound A

General Description

Green crystals or white crystalline solid. Melting point 215-217°F. Highly toxic.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

O-TOLUIDINE HYDROCHLORIDE acts as a weak acid. Incompatible with oxidizing agents and with alkalis .

Fire Hazard

Flash point data for O-TOLUIDINE HYDROCHLORIDE are not available; however, O-TOLUIDINE HYDROCHLORIDE is probably combustible.

Safety Profile

Confirmed carcinogen with experimental carcinogenic data. Poison by intraperitoneal route. Moderately toxic by ingestion. Mutation data reported. When heated to decomposition it emits very toxic fumes of HCl and NOx. See also o- TOLUIDINE.

Carcinogenicity

o-Toluidine and o-toluidine hydrochloride are reasonably anticipatedto be human carcinogens based on sufficient evidence of carcinogenicity from studies in experimental animals.