5-broMo-1-MethylpyriMidin-2-one
- Product Name
- 5-broMo-1-MethylpyriMidin-2-one
- CAS No.
- 14248-01-2
- Chemical Name
- 5-broMo-1-MethylpyriMidin-2-one
- Synonyms
- 5-Bromo-1-methyl-2-pyrimidone;5-Bromo-1-methylpyrimidin-2(1H);5-Bromo-1-methyl-2-pyrimidinone;5-broMo-1-MethylpyriMidin-2-one;5-Bromo-1-methyl-2(1H)-pyrimidinone;2(1H)-Pyrimidinone, 5-bromo-1-methyl-;5‐bromo‐1‐methyl‐1,2‐dihydropyrimidin‐2‐one
- CBNumber
- CB62645371
- Molecular Formula
- C5H5BrN2O
- Formula Weight
- 189.01
- MOL File
- 14248-01-2.mol
5-broMo-1-MethylpyriMidin-2-one Property
- Boiling point:
- 215.9±50.0 °C(Predicted)
- Density
- 1.73±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 0.31±0.10(Predicted)
- Appearance
- Off-white to light yellow Solid
Safety
- HS Code
- 2933599590
N-Bromosuccinimide Price
- Product number
- B678328
- Product name
- 5-Bromo-1-methylpyrimidin-2(1H)-one
- Packaging
- 500mg
- Price
- $175
- Updated
- 2021/12/16
- Product number
- OR928790
- Product name
- 5-Bromo-1-methylpyrimidin-2(1H)-one
- Purity
- 95%
- Packaging
- 250mg
- Price
- $205
- Updated
- 2021/12/16
- Product number
- FB143590
- Product name
- 5-Bromo-1-methylpyrimidin-2(1H)-one
- Packaging
- 1g
- Price
- $275
- Updated
- 2021/12/16
- Product number
- 119898
- Product name
- 5-Bromo-1-methylpyrimidin-2(1H)-one
- Purity
- 95+%
- Packaging
- 1g
- Price
- $298
- Updated
- 2021/12/16
- Product number
- FB143590
- Product name
- 5-Bromo-1-methylpyrimidin-2(1H)-one
- Packaging
- 2g
- Price
- $360
- Updated
- 2021/12/16
5-broMo-1-MethylpyriMidin-2-one Chemical Properties,Usage,Production
Synthesis
38353-06-9
74-88-4
14248-01-2
Step 1: Synthesis of 5-bromo-1-methylpyrimidin-2(1H)-one A mixture of 5-bromopyrimidin-2(1H)-one (3 g), iodomethane (1.1 mL) and potassium carbonate (2.4 g) in N,N-dimethylformamide (60 mL) was stirred for 5 hours at room temperature. After completion of the reaction, the mixture was filtered and the filtrate was concentrated. The residue was partitioned between water and dichloromethane. The organic phase was washed with brine, dried over anhydrous magnesium sulfate, and then concentrated to afford the target product 5-bromo-1-methylpyrimidin-2(1H)-one. Yield: 385 mg; liquid chromatography (Method 9): retention time t R = 0.25 min; mass spectrometry (ESI+): m/z = 189 [M + H]+.
References
[1] Patent: US2013/252937, 2013, A1. Location in patent: Paragraph 0767
[2] Patent: WO2013/144097, 2013, A1. Location in patent: Page/Page column 164
[3] Patent: WO2015/160636, 2015, A1. Location in patent: Page/Page column 155
[4] Patent: WO2015/160634, 2015, A1. Location in patent: Page/Page column 142
5-broMo-1-MethylpyriMidin-2-one Preparation Products And Raw materials
Raw materials
Preparation Products
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